KEGG   PATHWAY: mprf00260
Entry
mprf00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Marinomonas profundi
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mprf00260  Glycine, serine and threonine metabolism
mprf00260

Module
mprf_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mprf00260]
mprf_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mprf00260]
mprf_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:mprf00260]
mprf_M00555  Betaine biosynthesis, choline => betaine [PATH:mprf00260]
mprf_M00621  Glycine cleavage system [PATH:mprf00260]
mprf_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:mprf00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Marinomonas profundi [GN:mprf]
Gene
J8N69_03190  aspartate kinase [KO:K00928] [EC:2.7.2.4]
J8N69_04700  aspartate kinase [KO:K00928] [EC:2.7.2.4]
J8N69_16350  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
J8N69_04895  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
J8N69_08955  homoserine kinase [KO:K02204] [EC:2.7.1.39]
J8N69_04890  threonine synthase [KO:K01733] [EC:4.2.3.1]
J8N69_15335  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
J8N69_15685  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
J8N69_13795  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
J8N69_16080  D-2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
J8N69_03030  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
J8N69_05800  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
J8N69_07905  glycerate kinase [KO:K00865] [EC:2.7.1.165]
J8N69_10375  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
J8N69_04980  hypothetical protein [KO:K15918] [EC:2.7.1.31]
J8N69_01220  D-2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
J8N69_07215  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
J8N69_00585  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
J8N69_01720  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
J8N69_05180  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
J8N69_05185  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
J8N69_15675  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
J8N69_15690  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
J8N69_00280  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
J8N69_08245  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
J8N69_15680  gcvH; glycine cleavage system protein GcvH [KO:K02437]
J8N69_14350  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
J8N69_01645  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
J8N69_09135  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
J8N69_09140  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
J8N69_14355  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
J8N69_14360  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
J8N69_14255  dgcA; dimethylglycine demethylation protein DgcA [KO:K21833] [EC:1.5.7.3]
J8N69_14260  (Fe-S)-binding protein [KO:K21834]
J8N69_14265  electron transfer flavoprotein subunit alpha/FixB family protein [KO:K25960]
J8N69_14270  electron transfer flavoprotein subunit beta [KO:K25961]
J8N69_14185  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
J8N69_14175  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
J8N69_14190  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
J8N69_14180  sarcosine oxidase subunit delta family protein [KO:K00304] [EC:1.5.3.24 1.5.3.1]
J8N69_02960  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
J8N69_06755  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
J8N69_05705  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
J8N69_01090  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
J8N69_15005  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
J8N69_01085  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
J8N69_15000  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
J8N69_00025  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
J8N69_03200  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
J8N69_03205  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
J8N69_03195  ectoine synthase [KO:K06720] [EC:4.2.1.108]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mprf00010  Glycolysis / Gluconeogenesis
mprf00020  Citrate cycle (TCA cycle)
mprf00230  Purine metabolism
mprf00250  Alanine, aspartate and glutamate metabolism
mprf00270  Cysteine and methionine metabolism
mprf00290  Valine, leucine and isoleucine biosynthesis
mprf00300  Lysine biosynthesis
mprf00330  Arginine and proline metabolism
mprf00460  Cyanoamino acid metabolism
mprf00470  D-Amino acid metabolism
mprf00564  Glycerophospholipid metabolism
mprf00620  Pyruvate metabolism
mprf00630  Glyoxylate and dicarboxylate metabolism
mprf00640  Propanoate metabolism
mprf00680  Methane metabolism
mprf00860  Porphyrin metabolism
mprf00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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