KEGG   PATHWAY: oci00260
Entry
oci00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Oceanihabitans sp. IOP_32
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
oci00260  Glycine, serine and threonine metabolism
oci00260

Module
oci_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:oci00260]
oci_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:oci00260]
oci_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:oci00260]
oci_M00621  Glycine cleavage system [PATH:oci00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Oceanihabitans sp. IOP_32 [GN:oci]
Gene
FEZ18_07915  aspartate kinase [KO:K00928] [EC:2.7.2.4]
FEZ18_05565  aspartate kinase [KO:K00928] [EC:2.7.2.4]
FEZ18_01265  thrA; bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
FEZ18_09980  thrA; bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
FEZ18_07020  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
FEZ18_01270  homoserine kinase [KO:K00872] [EC:2.7.1.39]
FEZ18_01275  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
FEZ18_14450  threonine aldolase [KO:K01620] [EC:4.1.2.48]
FEZ18_11945  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
FEZ18_01155  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
FEZ18_05585  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FEZ18_13185  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FEZ18_13190  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
FEZ18_01100  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
FEZ18_07545  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
FEZ18_14430  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K00639] [EC:2.3.1.29]
FEZ18_02815  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
FEZ18_00525  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
FEZ18_11820  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FEZ18_12070  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FEZ18_04675  gcvH; glycine cleavage system protein GcvH [KO:K02437]
FEZ18_11060  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
FEZ18_11555  cysteine synthase family protein [KO:K01697] [EC:4.2.1.22]
FEZ18_14435  cysteine synthase family protein [KO:K01697] [EC:4.2.1.22]
FEZ18_05620  cystathionine gamma-synthase [KO:K01758] [EC:4.4.1.1]
FEZ18_12750  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
FEZ18_09875  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
FEZ18_10340  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
FEZ18_10350  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
oci00010  Glycolysis / Gluconeogenesis
oci00020  Citrate cycle (TCA cycle)
oci00230  Purine metabolism
oci00250  Alanine, aspartate and glutamate metabolism
oci00270  Cysteine and methionine metabolism
oci00290  Valine, leucine and isoleucine biosynthesis
oci00300  Lysine biosynthesis
oci00330  Arginine and proline metabolism
oci00460  Cyanoamino acid metabolism
oci00470  D-Amino acid metabolism
oci00564  Glycerophospholipid metabolism
oci00600  Sphingolipid metabolism
oci00620  Pyruvate metabolism
oci00630  Glyoxylate and dicarboxylate metabolism
oci00640  Propanoate metabolism
oci00680  Methane metabolism
oci00860  Porphyrin metabolism
oci00920  Sulfur metabolism
KO pathway
ko00260   
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