KEGG   PATHWAY: ocu04156
Entry
ocu04156                    Pathway                                
Name
Integrated stress response (ISR) signaling pathway - Oryctolagus cuniculus (rabbit)
Class
Cellular Processes; Cell growth and death
Pathway map
ocu04156  Integrated stress response (ISR) signaling pathway
ocu04156

Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008764  [KO:K09490] [EC:5.6.1.10]
100008883  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
100009013  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
100009285  EIF2S2; eukaryotic translation initiation factor 2 subunit 2 [KO:K03238]
100009298  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100009318  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
100009393  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
100009522  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
100009560  EIF2B4; translation initiation factor eIF-2B subunit delta [KO:K03680]
100009587  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100337749  [KO:K09032]
100338330  [KO:K23010]
100338439  [KO:K04452]
100338694  [KO:K04079]
100339093  [KO:K03237]
100339383  [KO:K04374]
100340751  [KO:K08341]
100341887  [KO:K08270]
100342544  [KO:K22758]
100342698  [KO:K08341]
100344591  [KO:K07232] [EC:4.3.2.7]
100344607  [KO:K03242]
100346243  [KO:K22758]
100346846  [KO:K03239]
100347046  [KO:K19518]
100347135  [KO:K04043]
100348406  [KO:K03241]
100348550  [KO:K07232] [EC:4.3.2.7]
100349912  [KO:K04077] [EC:5.6.1.7]
100350144  [KO:K22759]
100352399  [KO:K20403]
100353054  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100353512  [KO:K20402]
100354847  [KO:K08860] [EC:2.7.11.1]
100355359  DELE1; death ligand signal enhancer [KO:K29051]
100355737  [KO:K20064]
100356164  [KO:K07203] [EC:2.7.11.1]
100356340  [KO:K22429]
100356602  [KO:K11137]
100357623  [KO:K14019]
100357703  [KO:K10132]
100357764  [KO:K17558]
100358284  [KO:K16196] [EC:2.7.11.1]
100358690  [KO:K04079]
100359276  [KO:K08266]
103346553  [KO:K07204]
103349392  [KO:K10131]
103349871  [KO:K08341]
103351840  [KO:K04043]
127482734  [KO:K07204]
127485938  [KO:K03242]
127489858  [KO:K16184]
127489860  [KO:K09044]
127493986  [KO:K22758]
64985237  [KO:K14230]
Compound
C00032  Heme
C00035  GDP
C00044  GTP
Reference
PMID:38267546
  Authors
Lu HJ, Koju N, Sheng R
  Title
Mammalian integrated stress responses in stressed organelles and their functions.
  Journal
Acta Pharmacol Sin 45:1095-1114 (2024)
DOI:10.1038/s41401-023-01225-0
Reference
PMID:38139251
  Authors
Kalinin A, Zubkova E, Menshikov M
  Title
Integrated Stress Response (ISR) Pathway: Unraveling Its Role in Cellular Senescence.
  Journal
Int J Mol Sci 24:ijms242417423 (2023)
DOI:10.3390/ijms242417423
Reference
PMID:41511286
  Authors
Kalinin A, Zubkova E, Beloglazova I, Parfyonova Y, Menshikov M
  Title
Integrated Stress Response (ISR) Modulators in Vascular Diseases.
  Journal
Cells 15:cells15010002 (2025)
DOI:10.3390/cells15010002
Reference
PMID:41431742
  Authors
Jiang W, Hong Y, Wang P, Yang X, Shao K, Li M, Wu D
  Title
Current Knowledge of the Integrated Stress Response in the Development and Management of Acute Myeloid Leukemia: A Novel Target with Encouraging Progress.
  Journal
Drug Des Devel Ther 19:11269-11288 (2025)
DOI:10.2147/DDDT.S573043
Reference
PMID:35806136
  Authors
Paerhati P, Liu J, Jin Z, Jakos T, Zhu S, Qian L, Zhu J, Yuan Y
  Title
Advancements in Activating Transcription Factor 5 Function in Regulating Cell Stress and Survival.
  Journal
Int J Mol Sci 23:ijms23137129 (2022)
DOI:10.3390/ijms23137129
Reference
PMID:35173147
  Authors
Ruan Y, Hu J, Che Y, Liu Y, Luo Z, Cheng J, Han Q, He H, Zhou Q
  Title
CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.
  Journal
Cell Death Dis 13:156 (2022)
DOI:10.1038/s41419-022-04602-5
Related
pathway
ocu04140  Autophagy - animal
ocu04141  Protein processing in endoplasmic reticulum
ocu04150  mTOR signaling pathway
ocu04210  Apoptosis
KO pathway
ko04156   

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