KEGG   PATHWAY: paeb00230
Entry
paeb00230                   Pathway                                
Name
Purine metabolism - Pseudomonas aeruginosa NCGM 1900
Class
Metabolism; Nucleotide metabolism
Pathway map
paeb00230  Purine metabolism
paeb00230

Module
paeb_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:paeb00230]
paeb_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:paeb00230]
paeb_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:paeb00230]
paeb_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:paeb00230]
paeb_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:paeb00230]
paeb_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:paeb00230]
paeb_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:paeb00230]
Other DBs
GO: 0006163 0042278
Organism
Pseudomonas aeruginosa NCGM 1900 [GN:paeb]
Gene
NCGM1900_5718  aspP; adenosine diphosphate sugar pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
NCGM1900_5968  nudE; ADP-ribose diphosphatase [KO:K08312] [EC:3.6.1.-]
NCGM1900_6165  algC; phosphomannomutase [KO:K15778] [EC:5.4.2.8 5.4.2.2]
NCGM1900_5381  prs; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
NCGM1900_3191  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
NCGM1900_5594  purD; phosphoribosylamine-glycine ligase [KO:K01945] [EC:6.3.4.13]
NCGM1900_1773  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
NCGM1900_1231  hypothetical protein [KO:K08289] [EC:6.3.1.21]
NCGM1900_1218  purL; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
NCGM1900_1772  purM; phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
NCGM1900_6276  purK; phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
NCGM1900_6277  purE; phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
NCGM1900_1655  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
NCGM1900_3884  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
NCGM1900_2767  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
NCGM1900_2769  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
NCGM1900_5593  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
NCGM1900_5037  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
NCGM1900_2651  surE; stationary phase survival protein [KO:K03787] [EC:3.1.3.5 3.1.3.6]
NCGM1900_5969  putative hydrolase [KO:K20881] [EC:3.1.3.-]
NCGM1900_5002  yaiE; hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
NCGM1900_2381  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
NCGM1900_5115  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
NCGM1900_2493  hpt; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
NCGM1900_1210  guaB; inositol-5-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
NCGM1900_1170  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
NCGM1900_0392  putative deoxyribonucleotide triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
NCGM1900_6138  xpt; xanthine phosphoribosyltransferase [KO:K03816] [EC:2.4.2.22]
NCGM1900_5057  xdhA; xanthine dehydrogenase [KO:K13481] [EC:1.17.1.4]
NCGM1900_5058  xdhB; xanthine dehydrogenase [KO:K13482] [EC:1.17.1.4]
NCGM1900_4552  putative hydroxylase large subunit [KO:K11177] [EC:1.17.1.4]
NCGM1900_4553  putative hydroxylase molybdopterin-containing subunit [KO:K11178] [EC:1.17.1.4]
NCGM1900_4554  putative ferredoxin [KO:K13483]
NCGM1900_1211  guaA; bifunctional GMP synthase/glutamine amidotransferase protein [KO:K01951] [EC:6.3.5.2]
NCGM1900_0124  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
NCGM1900_5060  gda1; guanine deaminase [KO:K01487] [EC:3.5.4.3]
NCGM1900_4030  putative deaminase [KO:K01487] [EC:3.5.4.3]
NCGM1900_6179  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
NCGM1900_1438  nrdA; ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
NCGM1900_6356  putative ribonucleotide reductase [KO:K00525] [EC:1.17.4.1]
NCGM1900_1439  nrdB; ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
NCGM1900_4566  nrdD; anaerobic ribonucleoside triphosphate reductase [KO:K21636] [EC:1.1.98.6]
NCGM1900_3258  deoxyguanosinetriphosphate triphosphohydrolase-like protein [KO:K01129] [EC:3.1.5.1]
NCGM1900_1471  dgt; deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
NCGM1900_6181  spoT; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
NCGM1900_6039  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
NCGM1900_1784  relA; GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
NCGM1900_3081  cyaB; hypothetical protein [KO:K01768] [EC:4.6.1.1]
NCGM1900_6071  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
NCGM1900_5684  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
NCGM1900_0993  AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
NCGM1900_0845  hypothetical protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
NCGM1900_0140  add; adenosine deaminase [KO:K21053] [EC:3.5.4.2]
NCGM1900_2590  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
NCGM1900_1783  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
NCGM1900_5716  icc; hypothetical protein [KO:K03651] [EC:3.1.4.53]
NCGM1900_0606  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
NCGM1900_2272  cysN; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein [KO:K00955] [EC:2.7.7.4 2.7.1.25]
NCGM1900_2273  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
NCGM1900_5064  putative transthyretin family protein [KO:K07127] [EC:3.5.2.17]
NCGM1900_5066  hypothetical protein [KO:K13485] [EC:4.1.1.97]
NCGM1900_5065  hypothetical protein [KO:K16842] [EC:3.5.2.5]
NCGM1900_5067  alc; allantoicase [KO:K01477] [EC:3.5.3.4]
NCGM1900_1455  ylbA; hypothetical protein [KO:K14977] [EC:3.5.3.26]
NCGM1900_5068  allA; ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
NCGM1900_5608  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
NCGM1900_5607  ureB; urease subunit beta [KO:K01429] [EC:3.5.1.5]
NCGM1900_5605  ureA; urease subunit gamma [KO:K01430] [EC:3.5.1.5]
NCGM1900_5964  arcC; carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
paeb00030  Pentose phosphate pathway
paeb00220  Arginine biosynthesis
paeb00250  Alanine, aspartate and glutamate metabolism
paeb00260  Glycine, serine and threonine metabolism
paeb00340  Histidine metabolism
paeb00630  Glyoxylate and dicarboxylate metabolism
paeb00730  Thiamine metabolism
paeb00740  Riboflavin metabolism
paeb00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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