KEGG   PATHWAY: paec00260
Entry
paec00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas aeruginosa c7447m
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
paec00260  Glycine, serine and threonine metabolism
paec00260

Module
paec_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:paec00260]
paec_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:paec00260]
paec_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:paec00260]
paec_M00555  Betaine biosynthesis, choline => betaine [PATH:paec00260]
paec_M00621  Glycine cleavage system [PATH:paec00260]
paec_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:paec00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas aeruginosa c7447m [GN:paec]
Gene
M802_1086  [KO:K00865] [EC:2.7.1.165]
M802_1363  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
M802_1538  [KO:K11529] [EC:2.7.1.165]
M802_1629  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
M802_1802  thrH; phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein [KO:K02203] [EC:3.1.3.3 2.7.1.39]
M802_2320  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
M802_2482  [KO:K00836] [EC:2.6.1.76]
M802_2512  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
M802_2513  [KO:K01752] [EC:4.3.1.17]
M802_2514  [KO:K00600] [EC:2.1.2.1]
M802_2515  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
M802_2516  gcvH; glycine cleavage system H protein [KO:K02437]
M802_3224  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
M802_323  [KO:K00058] [EC:1.1.1.95 1.1.1.399]
M802_3276  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
M802_338  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
M802_3475  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
M802_36  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
M802_37  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
M802_3856  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
M802_3857  [KO:K00003] [EC:1.1.1.3]
M802_4023  [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
M802_409  [KO:K01697] [EC:4.2.1.22]
M802_410  metC; cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
M802_431  [KO:K00274] [EC:1.4.3.4]
M802_4752  glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
M802_4777  [KO:K00018] [EC:1.1.1.29]
M802_4854  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
M802_4960  [KO:K02437]
M802_4996  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
M802_5130  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
M802_5302  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
M802_5389  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
M802_5390  gcvH; glycine cleavage system H protein [KO:K02437]
M802_5391  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
M802_5555  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
M802_5556  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
M802_5562  [KO:K01752] [EC:4.3.1.17]
M802_5581  [KO:K21833] [EC:1.5.7.3]
M802_5582  [KO:K21834]
M802_5583  [KO:K25960]
M802_5584  [KO:K25961]
M802_5594  [KO:K00479] [EC:1.14.13.251]
M802_5596  [KO:K21832] [EC:1.14.13.251]
M802_5597  ltaE; low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
M802_5599  [KO:K00600] [EC:2.1.2.1]
M802_5600  [KO:K00303] [EC:1.5.3.24 1.5.3.1]
M802_5601  soxD; subunit delta of sarcosine oxidase [KO:K00304] [EC:1.5.3.24 1.5.3.1]
M802_5602  [KO:K00302] [EC:1.5.3.24 1.5.3.1]
M802_5603  soxG; sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
M802_5680  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
M802_874  [KO:K01754] [EC:4.3.1.19]
M802_926  [KO:K01620] [EC:4.1.2.48]
M802_928  [KO:K00928] [EC:2.7.2.4]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
paec00010  Glycolysis / Gluconeogenesis
paec00020  Citrate cycle (TCA cycle)
paec00230  Purine metabolism
paec00250  Alanine, aspartate and glutamate metabolism
paec00270  Cysteine and methionine metabolism
paec00290  Valine, leucine and isoleucine biosynthesis
paec00300  Lysine biosynthesis
paec00330  Arginine and proline metabolism
paec00460  Cyanoamino acid metabolism
paec00470  D-Amino acid metabolism
paec00564  Glycerophospholipid metabolism
paec00600  Sphingolipid metabolism
paec00620  Pyruvate metabolism
paec00630  Glyoxylate and dicarboxylate metabolism
paec00640  Propanoate metabolism
paec00680  Methane metabolism
paec00860  Porphyrin metabolism
paec00920  Sulfur metabolism
KO pathway
ko00260   

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