KEGG   PATHWAY: aai00260
Entry
aai00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Glutamicibacter arilaitensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
aai00260  Glycine, serine and threonine metabolism
aai00260

Module
aai_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:aai00260]
aai_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:aai00260]
aai_M00555  Betaine biosynthesis, choline => betaine [PATH:aai00260]
aai_M00621  Glycine cleavage system [PATH:aai00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Glutamicibacter arilaitensis [GN:aai]
Gene
AARI_03120  ask; aspartate kinase [KO:K00928] [EC:2.7.2.4]
AARI_23880  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AARI_12590  thrA; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AARI_12610  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
AARI_12600  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
AARI_19820  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AARI_27210  glyA; glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AARI_26190  glyA; glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AARI_10400  putative aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
AARI_33030  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
AARI_05230  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
AARI_14060  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AARI_05600  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
AARI_15970  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AARI_09040  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
AARI_09030  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
AARI_26060  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
AARI_26220  gcvP; glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
AARI_26210  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
AARI_20270  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AARI_26200  gcvH; glycine cleavage system H protein [KO:K02437]
AARI_18930  dao; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
AARI_27250  creatinase [KO:K08688] [EC:3.5.3.3]
AARI_07270  codA; choline oxidase [KO:K17755] [EC:1.1.3.17]
AARI_07260  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AARI_26100  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
AARI_30680  putative monomeric sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
AARI_27180  soxA; heterotetrameric sarcosine oxidase alpha-subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
AARI_27200  soxB; heterotetrameric sarcosine oxidase beta-subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
AARI_27170  soxG; heterotetrameric sarcosine oxidase gamma-subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
AARI_27190  soxD; heterotetrameric sarcosine oxidase delta-subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
AARI_24020  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
AARI_26180  sdaA; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
AARI_07480  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
AARI_19450  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
AARI_19460  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
AARI_09570  putative pyridoxal-dependent amino acid decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
aai00010  Glycolysis / Gluconeogenesis
aai00020  Citrate cycle (TCA cycle)
aai00230  Purine metabolism
aai00250  Alanine, aspartate and glutamate metabolism
aai00270  Cysteine and methionine metabolism
aai00290  Valine, leucine and isoleucine biosynthesis
aai00300  Lysine biosynthesis
aai00330  Arginine and proline metabolism
aai00460  Cyanoamino acid metabolism
aai00470  D-Amino acid metabolism
aai00564  Glycerophospholipid metabolism
aai00620  Pyruvate metabolism
aai00630  Glyoxylate and dicarboxylate metabolism
aai00640  Propanoate metabolism
aai00680  Methane metabolism
aai00860  Porphyrin metabolism
aai00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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