KEGG   PATHWAY: aalb00983
Entry
aalb00983                   Pathway                                
Name
Drug metabolism - other enzymes - Aedes albopictus (Asian tiger mosquito)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
aalb00983  Drug metabolism - other enzymes
aalb00983

Organism
Aedes albopictus (Asian tiger mosquito) [GN:aalb]
Gene
109419443  LOW QUALITY PROTEIN: inosine-5'-monophosphate dehydrogenase-like [KO:K00088] [EC:1.1.1.205]
115268929  inosine-5'-monophosphate dehydrogenase-like [KO:K00088] [EC:1.1.1.205]
115268931  inosine-5'-monophosphate dehydrogenase-like [KO:K00088] [EC:1.1.1.205]
109401710  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
109403004  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109403005  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109403074  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109398275  LOW QUALITY PROTEIN: xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109408662  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109408663  LOW QUALITY PROTEIN: xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109408694  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109413809  xanthine dehydrogenase 1-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109421858  aldehyde oxidase 3-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109429794  LOW QUALITY PROTEIN: xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
115268902  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109421851  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109408692  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109408675  xanthine dehydrogenase 1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109408695  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109403053  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109408659  xanthine dehydrogenase 1-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109419921  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
109417504  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
109422421  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
109429037  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
109417021  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
109426255  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B33 [KO:K00699] [EC:2.4.1.17]
109426260  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
115255070  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
115255075  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
115255433  UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
109622501  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
109429036  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
109398287  UDP-glucuronosyltransferase 2B13-like [KO:K00699] [EC:2.4.1.17]
109429787  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
109429550  UDP-glucuronosyltransferase-like isoform X1 [KO:K00699] [EC:2.4.1.17]
115267827  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
109429923  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
109397292  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
109424170  UDP-glucuronosyltransferase 2B15-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109430774  UDP-glucuronosyltransferase 2B20-like isoform X2 [KO:K00699] [EC:2.4.1.17]
109426253  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B20 [KO:K00699] [EC:2.4.1.17]
109426259  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
109426261  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
109410283  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109410290  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
109428084  UDP-glucuronosyltransferase 2B20-like isoform X2 [KO:K00699] [EC:2.4.1.17]
115254532  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
115254533  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
109398841  UDP-glucuronosyltransferase 2B13-like [KO:K00699] [EC:2.4.1.17]
109430808  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
115266639  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
115266666  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
109429175  UDP-glucuronosyltransferase 2B13-like [KO:K00699] [EC:2.4.1.17]
109410284  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
115269590  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
109423216  UDP-glucuronosyltransferase 3A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109401664  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
109411684  uncharacterized protein LOC109411684 [KO:K01489] [EC:3.5.4.5]
109404611  uncharacterized protein LOC109404611 [KO:K01489] [EC:3.5.4.5]
109402631  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
109424108  dihydropyrimidinase-like isoform X1 [KO:K01464] [EC:3.5.2.2]
109408394  dihydropyrimidinase-like isoform X1 [KO:K01464] [EC:3.5.2.2]
109416534  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
109433624  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
109408405  uridine-cytidine kinase-like isoform X1 [KO:K00876] [EC:2.7.1.48]
109414995  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
109426215  uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
109414508  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
109621992  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
109420799  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
109399514  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
109405148  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
109408005  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
109407619  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
109421591  nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
115254030  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
109429382  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
109425118  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
115266964  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
109417692  glutathione S-transferase E14-like isoform X2 [KO:K00799] [EC:2.5.1.18]
109417693  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
109417697  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109417698  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109417699  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109415316  glutathione S-transferase D4-like [KO:K00799] [EC:2.5.1.18]
109424791  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109424792  glutathione S-transferase D7 [KO:K00799] [EC:2.5.1.18]
109428446  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
109427516  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109427517  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109422153  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
109398253  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109414639  glutathione S-transferase 1 isoform X3 [KO:K00799] [EC:2.5.1.18]
109414646  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109414674  glutathione S-transferase D7 [KO:K00799] [EC:2.5.1.18]
109414675  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
109404182  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
109406531  glutathione S-transferase D7-like [KO:K00799] [EC:2.5.1.18]
109398226  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109419784  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109417558  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
109429681  glutathione S-transferase D7-like [KO:K00799] [EC:2.5.1.18]
109428444  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
109424805  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
109424803  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
109417695  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109417559  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109412993  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
109431675  glutathione S-transferase 1-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
115255008  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115255011  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115266234  glutathione S-transferase D4-like [KO:K00799] [EC:2.5.1.18]
115255340  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115255341  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115255342  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115255347  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115255349  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115255352  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115255365  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115255368  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115255369  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115255370  glutathione S-transferase E14-like [KO:K00799] [EC:2.5.1.18]
115256453  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115256454  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115256455  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109417694  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115255501  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115255504  uncharacterized protein LOC115255504 [KO:K00799] [EC:2.5.1.18]
109413318  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
109424779  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115253692  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115259235  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115262057  glutathione S-transferase D7-like [KO:K00799] [EC:2.5.1.18]
109413322  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109413319  glutathione S-transferase D5-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

DBGET integrated database retrieval system