KEGG   PATHWAY: aamp00982
Entry
aamp00982                   Pathway                                
Name
Drug metabolism - cytochrome P450 - Arvicola amphibius (Eurasian water vole)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
aamp00982  Drug metabolism - cytochrome P450
aamp00982

Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119800635  Fmo5; flavin-containing monooxygenase 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
119827747  flavin-containing monooxygenase 5-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
119827897  flavin-containing monooxygenase 5-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
119827919  Fmo2; dimethylaniline monooxygenase [N-oxide-forming] 2 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
119827920  Fmo1; dimethylaniline monooxygenase [N-oxide-forming] 1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
119827930  dimethylaniline monooxygenase [N-oxide-forming] 3 isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
119827115  flavin-containing monooxygenase 5-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
119827122  putative dimethylaniline monooxygenase [N-oxide-forming] 6 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
119827355  dimethylaniline monooxygenase [N-oxide-forming] 4-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
119800665  LOW QUALITY PROTEIN: glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
119800819  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
119800820  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
119800821  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
119800822  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
119800823  glutathione S-transferase Mu 4 isoform X1 [KO:K00799] [EC:2.5.1.18]
119800824  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
119800825  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
119800828  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
119828086  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
119809017  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
119809018  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
119809423  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
119822331  LOW QUALITY PROTEIN: glutathione S-transferase alpha-3-like [KO:K00799] [EC:2.5.1.18]
119822623  glutathione S-transferase A6 [KO:K00799] [EC:2.5.1.18]
119822639  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
119809666  glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
119822842  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
119823006  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
119823076  glutathione S-transferase theta-2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
119810380  Gsto2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
119810407  Gsto1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
119817036  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
119805014  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
119805073  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
119826537  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
119826538  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
119806887  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
119821268  LOW QUALITY PROTEIN: glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
119817596  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
119823311  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
119819479  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
119806933  Gstk1; glutathione S-transferase kappa 1 isoform X1 [KO:K13299] [EC:2.5.1.18]
119807086  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
119826793  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
119807046  Hpgds; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
119801203  Adh7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 [KO:K13951] [EC:1.1.1.1]
119801407  alcohol dehydrogenase 1-like [KO:K13951] [EC:1.1.1.1]
119801408  alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
119801409  alcohol dehydrogenase 1-like isoform X1 [KO:K13951] [EC:1.1.1.1]
119801410  alcohol dehydrogenase 1-like isoform X1 [KO:K13951] [EC:1.1.1.1]
119800708  all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform X1 [KO:K13980] [EC:1.1.1.1]
119800710  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
119800803  alcohol dehydrogenase 6 isoform X1 [KO:K13952] [EC:1.1.1.1]
119814495  Aldh3b1; aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
119823135  Aldh3b2; aldehyde dehydrogenase family 3 member B2 [KO:K00129] [EC:1.2.1.5]
119812630  Aldh3a1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
119804577  Maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
119804656  Maoa; LOW QUALITY PROTEIN: amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
119803860  LOW QUALITY PROTEIN: aldehyde oxidase 1-like [KO:K00157] [EC:1.2.3.1]
119803866  aldehyde oxidase 4 isoform X1 [KO:K00157] [EC:1.2.3.1]
119803907  aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
119803936  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
119807749  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119821012  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
119821939  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
119821940  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
119822847  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119822864  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119822892  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119817029  UDP-glucuronosyltransferase 2A2 isoform X2 [KO:K00699] [EC:2.4.1.17]
119812268  UDP-glucuronosyltransferase 2A3-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119806347  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
119826010  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119826027  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
119826038  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
119826049  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119820370  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
119807687  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
119807696  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119807714  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
119807722  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
119807732  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119820660  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
119820716  UDP-glucuronosyltransferase 1-2 isoform X1 [KO:K00699] [EC:2.4.1.17]
119820717  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
119820718  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
119820719  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
119820720  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
119820721  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
119820722  UDP-glucuronosyltransferase 1A7-like [KO:K00699] [EC:2.4.1.17]
119820723  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
119820726  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
119820794  UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
119808953  cytochrome P450 1A2-like isoform X1 [KO:K07409] [EC:1.14.14.1]
119808954  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
119808956  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
119809971  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
LinkDB

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