KEGG PATHWAY: adr00260

PATHWAY: adr00260

Entry

adr00260                    Pathway

Name

Glycine, serine and threonine metabolism - Apis dorsata (giant honeybee)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

adr00260

Glycine, serine and threonine metabolism

Module

adr_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:adr00260]

adr_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:adr00260]

adr_M00621

Glycine cleavage system [PATH:adr00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Apis dorsata (giant honeybee) [GN:adr]

Gene

102677228

probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

102680229

serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]

102679677

serine--pyruvate aminotransferase, mitochondrial [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

102677566

glyoxylate reductase/hydroxypyruvate reductase-like isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]

102679805

glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]

102676485

glycerate kinase-like [KO:K11529] [EC:2.7.1.165]

102675397

glycerate kinase [KO:K11529] [EC:2.7.1.165]

102671561

phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

102676843

D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

102678139

probable phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

102675823

phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]

102679518

2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X1 [KO:K00639] [EC:2.3.1.29]

102679647

L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]

102675616

5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]

102672135

glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]

102678987

aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

102681062

dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]

102681718

dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

102673821

glycine cleavage system H protein, mitochondrial [KO:K02437]

102677809

alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

102671172

putative aldehyde dehydrogenase family 7 member A1 homolog [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

102676389

glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

102677189

cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]

102675006

putative cystathionine gamma-lyase 2 [KO:K01758] [EC:4.4.1.1]

102681525

uncharacterized protein LOC102681525 [KO:K01754] [EC:4.3.1.19]

102681649

uncharacterized protein LOC102681649 [KO:K01754] [EC:4.3.1.19]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721