KEGG   PATHWAY: aec04150
Entry
aec04150                    Pathway                                
Name
mTOR signaling pathway - Acromyrmex echinatior (Panamanian leafcutter ant)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
aec04150  mTOR signaling pathway
aec04150

Organism
Acromyrmex echinatior (Panamanian leafcutter ant) [GN:aec]
Gene
105145577  Y+L amino acid transporter 2 [KO:K13780]
105146689  Y+L amino acid transporter 2 [KO:K13780]
105144744  maltase 1 isoform X1 [KO:K06519]
105146483  putative sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
105143572  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
105146530  V-type proton ATPase subunit B [KO:K02147]
105153823  V-type proton ATPase subunit C [KO:K02148]
105145532  V-type proton ATPase subunit D [KO:K02149]
105150380  probable V-type proton ATPase subunit D 2 [KO:K02149]
105155000  V-type proton ATPase subunit E [KO:K02150]
105146691  V-type proton ATPase subunit F 1 [KO:K02151]
105148825  V-type proton ATPase subunit G [KO:K02152]
105143156  V-type proton ATPase subunit H-like [KO:K02144]
105145145  ragulator complex protein LAMTOR1 [KO:K20397]
105150260  ragulator complex protein LAMTOR2 [KO:K20398]
105147738  ragulator complex protein LAMTOR3-A isoform X1 [KO:K04370]
105154980  ragulator complex protein LAMTOR4 homolog isoform X1 [KO:K20399]
105148172  uncharacterized protein LOC105148172 [KO:K16344]
105148736  folliculin [KO:K09594]
105151259  folliculin-interacting protein 1 isoform X1 [KO:K20401]
105142920  LOW QUALITY PROTEIN: ras-related GTP-binding protein A [KO:K16185]
105148920  ras-related GTP-binding protein C [KO:K16186]
105151737  WD repeat-containing protein mio-B isoform X1 [KO:K20407]
105145416  nucleoporin SEH1 isoform X1 [KO:K14299]
105146470  WD repeat-containing protein 24 [KO:K20408]
105154506  LOW QUALITY PROTEIN: WD repeat-containing protein 59 [KO:K20409]
105145706  protein SEC13 homolog [KO:K14004]
105151914  DEP domain-containing protein 5-like [KO:K20404]
105151048  nitrogen permease regulator 2-like protein isoform X1 [KO:K20405]
105150741  nitrogen permease regulator 3-like protein isoform X1 [KO:K20406]
105143861  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
105143266  regulatory-associated protein of mTOR [KO:K07204]
105152845  LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105148033  target of rapamycin complex subunit lst8 [KO:K08266]
105146363  TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
105144307  restin homolog isoform X1 [KO:K10421]
105149560  LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
105144246  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
105144655  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
105152728  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
105143348  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
105154367  LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
105147090  eukaryotic translation initiation factor 4B-like [KO:K03258]
105148494  40S ribosomal protein S6 [KO:K02991]
105146890  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
105152783  protein Mo25 isoform X1 [KO:K08272]
105146359  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
105149474  LOW QUALITY PROTEIN: hamartin [KO:K07206]
105148228  tuberin [KO:K07207]
105148191  TBC1 domain family member 7 [KO:K20396]
105149880  GTP-binding protein Rheb homolog [KO:K07208]
105150858  protein Wnt-1 [KO:K03209]
105151550  protein Wnt-4-like [KO:K00408]
105151721  protein Wnt-5b-like isoform X1 [KO:K00444]
105150855  protein Wnt-6-like isoform X1 [KO:K00445]
105150856  protein Wnt-10a [KO:K01357]
105146334  protein Wnt-11b-2-like [KO:K01384]
105149687  frizzled-7-B [KO:K02432]
105150367  frizzled-4 [KO:K02354]
105153294  frizzled-2 [KO:K02375]
105148106  frizzled-9-like [KO:K02842]
105153162  low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
105148755  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
105152459  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
105147535  inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X1 [KO:K07209] [EC:2.7.11.10]
105147653  LIRP isoform X1 [KO:K04526]
105154102  insulin-like growth factor II isoform X1 [KO:K05459]
105148473  protein enhancer of sevenless 2B [KO:K04364]
105146854  protein son of sevenless isoform X1 [KO:K03099]
105153748  uncharacterized protein LOC105153748 [KO:K03099]
105154073  GTPase HRas [KO:K07827]
105146178  raf homolog serine/threonine-protein kinase phl isoform X1 [KO:K04365] [EC:2.7.11.1]
105151971  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
105149454  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105144083  ribosomal protein S6 kinase 2 beta [KO:K04373] [EC:2.7.11.1]
105146271  flocculation protein FLO11-like [KO:K16172]
105151362  insulin receptor substrate 1 [KO:K16172]
105151922  uncharacterized protein LOC105151922 [KO:K02649]
105149725  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105148783  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105144913  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105147255  RAC serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105151227  target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
105154593  rapamycin-insensitive companion of mTOR [KO:K08267]
105148010  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
105150950  protein kinase C, brain isozyme isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
aec00561  Glycerolipid metabolism
aec04140  Autophagy - animal
KO pathway
ko04150   
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