KEGG   PATHWAY: aew03008
Entry
aew03008                    Pathway                                
Name
Ribosome biogenesis in eukaryotes - Actinidia eriantha (wild kiwifruit)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
Pathway map
aew03008  Ribosome biogenesis in eukaryotes
aew03008

Organism
Actinidia eriantha (wild kiwifruit) [GN:aew]
Gene
130773587  casein kinase II subunit beta-1-like isoform X1 [KO:K03115]
130774527  putative casein kinase II subunit beta-4 isoform X1 [KO:K03115]
130763511  casein kinase II subunit beta-1-like isoform X1 [KO:K03115]
130765087  casein kinase II subunit beta-3-like isoform X1 [KO:K03115]
130766271  casein kinase II subunit beta-3-like isoform X1 [KO:K03115]
130793512  putative casein kinase II subunit beta-4 isoform X1 [KO:K03115]
130781309  putative casein kinase II subunit beta-4 isoform X1 [KO:K03115]
130793926  casein kinase II subunit beta-1-like isoform X1 [KO:K03115]
130794613  putative casein kinase II subunit beta-4 [KO:K03115]
130795454  putative casein kinase II subunit beta-4 [KO:K03115]
130784054  putative casein kinase II subunit beta-4 [KO:K03115]
130776120  casein kinase II subunit alpha-2-like [KO:K03097] [EC:2.7.11.1]
130778531  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
130778589  casein kinase II subunit alpha-2-like isoform X1 [KO:K03097] [EC:2.7.11.1]
130769107  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
130769381  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
130758862  casein kinase II subunit alpha-2 [KO:K03097] [EC:2.7.11.1]
130785276  casein kinase II subunit alpha-2-like [KO:K03097] [EC:2.7.11.1]
130769244  uncharacterized protein LOC130769244 isoform X1 [KO:K14544]
130777263  uncharacterized protein LOC130777263 isoform X1 [KO:K14545]
130768771  uncharacterized protein LOC130768771 isoform X1 [KO:K14545]
130787867  uncharacterized protein LOC130787867 isoform X1 [KO:K14546]
130796154  uncharacterized protein LOC130796154 isoform X1 [KO:K14546]
130771775  LOW QUALITY PROTEIN: uncharacterized protein LOC130771775 [KO:K14546]
130776132  WD repeat-containing protein PCN-like [KO:K14548]
130759089  WD repeat-containing protein PCN-like [KO:K14548]
130751310  protein SLOW WALKER 1 [KO:K14549]
130769330  LOW QUALITY PROTEIN: uncharacterized protein At3g06530 [KO:K14550]
130772503  uncharacterized protein LOC130772503 [KO:K14552]
130762246  U3 small nucleolar RNA-associated protein 18 homolog [KO:K14553]
130795167  LOW QUALITY PROTEIN: U3 small nucleolar RNA-associated protein 21 homolog [KO:K14554]
130753503  protein TORMOZ EMBRYO DEFECTIVE [KO:K14555]
130753451  uncharacterized protein LOC130753451 [KO:K14556]
130752506  uncharacterized protein LOC130752506 [KO:K14557]
130787728  periodic tryptophan protein 2-like [KO:K14558]
130795961  LOW QUALITY PROTEIN: periodic tryptophan protein 2-like [KO:K14558]
130762940  M phase phosphoprotein 10-like [KO:K14559]
130754878  M phase phosphoprotein 10-like [KO:K14559]
130774345  uncharacterized protein LOC130774345 [KO:K14560]
130752984  uncharacterized protein LOC130752984 isoform X1 [KO:K14560]
130795074  uncharacterized protein LOC130795074 [KO:K14561]
130783610  uncharacterized protein LOC130783610 [KO:K14561]
130752782  rRNA 2'-O-methyltransferase fibrillarin 2-like [KO:K14563] [EC:2.1.1.-]
130767868  rRNA 2'-O-methyltransferase fibrillarin 2-like [KO:K14563] [EC:2.1.1.-]
130766792  LOW QUALITY PROTEIN: nucleolar protein 56-like [KO:K14564]
130796041  nucleolar protein 56-like [KO:K14564]
130785933  probable nucleolar protein 5-2 [KO:K14565]
130780541  probable nucleolar protein 5-2 isoform X1 [KO:K14565]
130783601  probable nucleolar protein 5-2 [KO:K14565]
130791198  uncharacterized protein LOC130791198 [KO:K12845]
130779798  uncharacterized protein LOC130779798 [KO:K12845]
130781993  uncharacterized protein LOC130781993 [KO:K12845]
130771824  uncharacterized protein LOC130771824 [KO:K12845]
130784832  uncharacterized protein LOC130784832 [KO:K12845]
130784868  uncharacterized protein LOC130784868 [KO:K12845]
130774342  H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131] [EC:5.4.99.-]
130762916  H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131] [EC:5.4.99.-]
130791926  H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131] [EC:5.4.99.-]
130750048  H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129]
130763141  H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129]
130767295  H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129]
130754961  H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129]
130772595  putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128]
130791603  putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128]
130793712  putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128]
130761114  H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130]
130791373  H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130]
130752765  uncharacterized protein LOC130752765 [KO:K14566]
130751428  LOW QUALITY PROTEIN: uncharacterized protein LOC130751428 [KO:K14567]
130770666  uncharacterized protein LOC130770666 [KO:K14567]
130773214  uncharacterized protein LOC130773214 [KO:K14568] [EC:2.1.1.260]
130752153  uncharacterized protein LOC130752153 [KO:K14568] [EC:2.1.1.260]
130783501  LOW QUALITY PROTEIN: uncharacterized protein LOC130783501 [KO:K14569]
130785023  RNA cytidine acetyltransferase 1 [KO:K14521] [EC:2.3.1.-]
130772895  probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108]
130774546  probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108]
130776871  probable RNA 3'-terminal phosphate cyclase-like protein isoform X1 [KO:K11108]
130753622  probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108]
130762552  ribonucleases P/MRP protein subunit POP1 [KO:K01164] [EC:3.1.26.5]
130775530  probable ribonuclease P/MRP protein subunit POP5 [KO:K03537] [EC:3.1.26.5]
130752883  probable ribonuclease P/MRP protein subunit POP5 isoform X1 [KO:K03537] [EC:3.1.26.5]
130762823  protein GAMETOPHYTE DEFECTIVE 1 isoform X1 [KO:K03539] [EC:3.1.26.5]
130790529  protein GAMETOPHYTE DEFECTIVE 1-like [KO:K03539] [EC:3.1.26.5]
130787645  small RNA degrading nuclease 5 isoform X1 [KO:K14570] [EC:3.1.-.-]
130777400  small RNA degrading nuclease 1-like isoform X1 [KO:K14570] [EC:3.1.-.-]
130768290  small RNA degrading nuclease 1-like [KO:K14570] [EC:3.1.-.-]
130794171  oligoribonuclease-like isoform X1 [KO:K13288] [EC:3.1.-.-]
130770692  oligoribonuclease-like isoform X1 [KO:K13288] [EC:3.1.-.-]
130776062  5'-3' exoribonuclease 3-like isoform X1 [KO:K12619] [EC:3.1.13.-]
130759255  5'-3' exoribonuclease 3-like isoform X1 [KO:K12619] [EC:3.1.13.-]
130791494  LOW QUALITY PROTEIN: nucleolar GTP-binding protein 1-like [KO:K06943]
130795413  uncharacterized protein LOC130795413 isoform X1 [KO:K06943]
130772474  nucleolar GTP-binding protein 1-like [KO:K06943]
130755619  nuclear/nucleolar GTPase 2 [KO:K14537]
130762726  guanine nucleotide-binding protein-like NSN1 isoform X1 [KO:K14538]
130790596  guanine nucleotide-binding protein-like NSN1 [KO:K14538]
130795394  cell division control protein 48 homolog C [KO:K14571]
130788320  LOW QUALITY PROTEIN: midasin-like [KO:K14572]
130784642  uncharacterized protein LOC130784642 isoform X1 [KO:K14573]
130793468  RNA-binding NOB1-like protein [KO:K11883]
130761671  GTP-binding nuclear protein Ran/TC4 [KO:K07936]
130788453  GTP-binding nuclear protein Ran-3-like [KO:K07936]
130765183  GTP-binding nuclear protein Ran-3 [KO:K07936]
130790784  GTP-binding nuclear protein Ran-3-like [KO:K07936]
130754708  GTP-binding nuclear protein Ran/TC4-like [KO:K07936]
130784310  GTP-binding nuclear protein Ran-3-like [KO:K07936]
130760704  protein EXPORTIN 1A-like isoform X1 [KO:K14290]
130790010  protein EXPORTIN 1A-like isoform X1 [KO:K14290]
130790430  protein EXPORTIN 1A-like isoform X1 [KO:K14290]
130753174  protein EXPORTIN 1A-like [KO:K14290]
130766518  protein EXPORTIN 1A isoform X1 [KO:K14290]
130784992  LOW QUALITY PROTEIN: uncharacterized protein LOC130784992 [KO:K07562]
130778150  eukaryotic translation initiation factor 6-2 [KO:K03264]
130778167  eukaryotic translation initiation factor 6-2 [KO:K03264]
130784604  eukaryotic translation initiation factor 6-2-like [KO:K03264]
130759144  eukaryotic translation initiation factor 6-2-like [KO:K03264]
130785061  eukaryotic translation initiation factor 6-2-like isoform X1 [KO:K03264]
130785113  eukaryotic translation initiation factor 6-2-like isoform X1 [KO:K03264]
130776300  uncharacterized protein LOC130776300 [KO:K14574]
130759103  uncharacterized protein LOC130759103 isoform X1 [KO:K14574]
130756932  uncharacterized protein LOC130756932 [KO:K14536] [EC:3.6.5.-]
130795551  LOW QUALITY PROTEIN: uncharacterized protein LOC130795551 [KO:K14536] [EC:3.6.5.-]
130767850  GTPase LSG1-2-like [KO:K14539] [EC:3.6.1.-]
130762106  adenylate kinase isoenzyme 6 homolog isoform X1 [KO:K18532] [EC:2.7.4.3]
130773318  uncharacterized protein LOC130773318 [KO:K07178] [EC:2.7.11.1]
130763009  uncharacterized protein LOC130763009 [KO:K07178] [EC:2.7.11.1]
130755760  uncharacterized protein LOC130755760 [KO:K07178] [EC:2.7.11.1]
130777311  serine/threonine-protein kinase rio2 [KO:K07179] [EC:2.7.11.1]
130769532  18S ribosomal RNA [KO:K01979]
130769539  28S ribosomal RNA [KO:K01982]
130775747  small nucleolar RNA U3 [KO:K14483]
Reference
PMID:20174677
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
PMID:17515605
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
PMID:19850913
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
PMID:15120992
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
PMID:19879902
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
Related
pathway
aew03010  Ribosome
KO pathway
ko03008   
LinkDB

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