KEGG   PATHWAY: afun00983
Entry
afun00983                   Pathway                                
Name
Drug metabolism - other enzymes - Anopheles funestus (African malaria mosquito)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
afun00983  Drug metabolism - other enzymes
afun00983

Organism
Anopheles funestus (African malaria mosquito) [GN:afun]
Gene
125771545  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
125762613  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
125762820  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
125762821  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
125770889  uncharacterized protein LOC125770889 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
125770891  uncharacterized protein LOC125770891 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
125766941  uncharacterized protein LOC125766941 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
125766942  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
125767865  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
125767867  uncharacterized protein LOC125767867 isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
125767868  uncharacterized protein LOC125767868 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
125763336  inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
125760550  neuroligin-3 isoform X1 [KO:K01044] [EC:3.1.1.1]
125769210  esterase-5B-like [KO:K01044] [EC:3.1.1.1]
125769212  venom carboxylesterase-6-like [KO:K01044] [EC:3.1.1.1]
125769213  venom carboxylesterase-6-like [KO:K01044] [EC:3.1.1.1]
125771618  uncharacterized protein LOC125771618 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
125772418  uncharacterized protein LOC125772418 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
125762066  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
125769247  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
125769249  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
125762508  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
125762827  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
125762828  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
125771154  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
125771230  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
125771231  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
125771232  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
125771308  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
125771881  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
125764497  UDP-glycosyltransferase UGT4-like [KO:K00699] [EC:2.4.1.17]
125766238  UDP-glucuronosyltransferase 2B17-like isoform X1 [KO:K00699] [EC:2.4.1.17]
125766255  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
125768060  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
125769146  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
125764321  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
125770154  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
125763602  cytidine deaminase-like isoform X1 [KO:K01489] [EC:3.5.4.5]
125768230  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
125763273  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
125764257  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
125769851  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
125770657  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
125765340  uridine-cytidine kinase isoform X1 [KO:K00876] [EC:2.7.1.48]
125761280  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
125764031  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
125761579  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
125771693  ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
125767586  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
125768941  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
125762644  deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
125763585  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
125771765  microsomal glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
125771770  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
125763873  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
125763977  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
125763982  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
125763983  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
125763984  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
125763985  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
125763986  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
125772407  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
125773496  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
125766158  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
125760821  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
125760825  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
125760826  glutathione S-transferase D5-like [KO:K00799] [EC:2.5.1.18]
125760828  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
125760829  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
125760831  glutathione S-transferase D5-like [KO:K00799] [EC:2.5.1.18]
125760833  glutathione S-transferase D5-like [KO:K00799] [EC:2.5.1.18]
125760996  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
125761303  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
125761308  glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
125761313  glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
125761314  glutathione S-transferase D7 [KO:K00799] [EC:2.5.1.18]
125761315  glutathione S-transferase D1-like [KO:K00799] [EC:2.5.1.18]
125761316  glutathione S-transferase 4-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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