KEGG   PATHWAY: ame04013
Entry
ame04013                    Pathway                                
Name
MAPK signaling pathway - fly - Apis mellifera (honey bee)
Description
The mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role in mitosis, apoptosis, motility and metabolism. In fruit fly, three major classes of MAPK pathways have been distinguished with little or no redundancy, including extracellular signal-regulated kinase (ERK) / Rolled, c-Jun N-terminal kinase (JNK) / Bsk, and p38 kinase. Signals from growth factors or mitogens are dominantly transduced by the ERK pathway, whereas the JNK and p38 pathways are activated mostly by environmental stresses. The MAPK signaling cascades are typically linked to regulation of gene expression, because transcription factors are often the targets of regulatory phosphorylation events.
Class
Environmental Information Processing; Signal transduction
Pathway map
ame04013  MAPK signaling pathway - fly
ame04013

Other DBs
GO: 0000165
Organism
Apis mellifera (honey bee) [GN:ame]
Gene
411173  torso-like protein [KO:K12377]
100577521  uncharacterized protein LOC100577521 [KO:K20227]
100578699  uncharacterized protein LOC100578699 [KO:K20228]
100577214  protein giant-lens [KO:K02104]
113218545  ras-interacting protein RIP3-like [KO:K16690]
100577697  uncharacterized protein LOC100577697 isoform X1 [KO:K16691]
100577393  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
552187  leucine-rich repeat-containing protein 4 [KO:K20230]
726228  protein bride of sevenless isoform X1 [KO:K04623]
410671  proto-oncogene tyrosine-protein kinase ROS isoform X2 [KO:K05088] [EC:2.7.10.1]
412172  SHC-transforming protein 1 isoform X1 [KO:K06279]
550857  protein enhancer of sevenless 2B [KO:K04364]
412529  tyrosine-protein phosphatase corkscrew isoform X1 [KO:K07293] [EC:3.1.3.48]
552718  protein son of sevenless isoform X1 [KO:K03099]
725117  protein sprouty homolog 2 isoform X2 [KO:K17383]
410812  ras-like protein 1 [KO:K07827]
410811  ras GTPase-activating protein 1 [KO:K04352]
412003  ras GTPase-activating protein 3 isoform X1 [KO:K12380]
413448  raf homolog serine/threonine-protein kinase Raf [KO:K04365] [EC:2.7.11.1]
102655329  14-3-3 protein zeta isoform X1 [KO:K16197]
550710  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
409498  kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
409925  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
409523  mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
551725  importin-7 [KO:K20223]
100578885  putative transcription factor capicua isoform X1 [KO:K20225]
725327  nuclear receptor subfamily 2 group E member 1 [KO:K08545]
408894  protein groucho isoform X1 [KO:K04497]
408890  protein groucho isoform X2 [KO:K04497]
411175  protein groucho isoform X2 [KO:K04497]
100578561  early growth response protein 1 [KO:K12379]
412916  ETS-like protein pointed isoform X1 [KO:K02678]
100576369  ets DNA-binding protein pokkuri isoform X1 [KO:K03211]
413018  exportin-1 [KO:K14290]
410918  protein tramtrack, alpha isoform isoform X1 [KO:K09237]
410808  E3 ubiquitin-protein ligase Siah1 [KO:K04506] [EC:2.3.2.27]
410184  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
724793  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
410537  protein lozenge [KO:K20214]
406073  homeobox protein prospero isoform X1 [KO:K20211]
725245  protein eiger isoform X2 [KO:K16678]
726958  tumor necrosis factor receptor superfamily member wengen isoform X1 [KO:K16679]
410622  uncharacterized protein LOC410622 [KO:K20234]
412588  tyrosine-protein kinase Src42A isoform X3 [KO:K08892] [EC:2.7.10.2]
413464  tyrosine-protein kinase Src64B isoform X1 [KO:K05704] [EC:2.7.10.2]
410649  tyrosine-protein kinase Btk29A isoform X1 [KO:K07364] [EC:2.7.10.2]
413504  serine/threonine-protein kinase mig-15 isoform X1 [KO:K08840] [EC:2.7.11.1]
551554  ras-related protein Rac1 [KO:K04392]
552138  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
552419  ras-like GTP-binding protein RhoL isoform X1 [KO:K04392]
551819  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
410344  ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
726947  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K04404]
411566  mitogen-activated protein kinase kinase kinase 10 isoform X2 [KO:K04417] [EC:2.7.11.25]
413809  mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
107964404  protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
413389  dual specificity mitogen-activated protein kinase kinase hemipterous [KO:K04431] [EC:2.7.12.2]
410575  dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
409286  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
550685  striatin-3 isoform X2 [KO:K17608]
726289  transcription factor AP-1 [KO:K04448]
724169  transcription factor kayak isoform X1 [KO:K09031]
100577174  ras-responsive element-binding protein 1 isoform X1 [KO:K20210]
727101  protein decapentaplegic [KO:K04662]
406154  PRF; profilin [KO:K05759]
408844  dual specificity protein phosphatase 10 isoform X2 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
408442  bone morphogenetic protein receptor type-1B isoform X2 [KO:K13578] [EC:2.7.11.30]
409125  mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
408533  mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]
725374  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04432] [EC:2.7.12.2]
411915  mitogen-activated protein kinase p38b isoform X1 [KO:K04441] [EC:2.7.11.24]
100576527  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
551970  dual oxidase isoform X3 [KO:K13411] [EC:1.6.3.1 1.11.1.-]
726842  optomotor-blind protein isoform X1 [KO:K10176]
413946  myocyte-specific enhancer factor 2 isoform X1 [KO:K09260]
410082  Sod2; superoxide dismutase 2, mitochondrial [KO:K04564] [EC:1.15.1.1]
Reference
PMID:23732470
  Authors
Sopko R, Perrimon N
  Title
Receptor tyrosine kinases in Drosophila development.
  Journal
Cold Spring Harb Perspect Biol 5:a009050 (2013)
DOI:10.1101/cshperspect.a009050
Reference
PMID:15704136
  Authors
Li WX
  Title
Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.
  Journal
Dev Dyn 232:656-72 (2005)
DOI:10.1002/dvdy.20295
Reference
PMID:12648473
  Authors
Shilo BZ
  Title
Signaling by the Drosophila epidermal growth factor receptor pathway during development.
  Journal
Exp Cell Res 284:140-9 (2003)
DOI:10.1016/S0014-4827(02)00094-0
Reference
PMID:10771085
  Authors
Raabe T
  Title
The sevenless signaling pathway: variations of a common theme.
  Journal
Biochim Biophys Acta 1496:151-63 (2000)
DOI:10.1016/S0167-4889(00)00020-3
Reference
PMID:23109363
  Authors
Rios-Barrera LD, Riesgo-Escovar JR
  Title
Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway.
  Journal
Genesis 51:147-62 (2013)
DOI:10.1002/dvg.22354
Reference
PMID:24981286
  Authors
Igaki T, Miura M
  Title
The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.
  Journal
Semin Immunol 26:267-74 (2014)
DOI:10.1016/j.smim.2014.05.003
Reference
PMID:16014325
  Authors
Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX
  Title
Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli.
  Journal
Cell Signal 18:441-8 (2006)
DOI:10.1016/j.cellsig.2005.05.013
Reference
PMID:10557109
  Authors
Stronach BE, Perrimon N
  Title
Stress signaling in Drosophila.
  Journal
Oncogene 18:6172-82 (1999)
DOI:10.1038/sj.onc.1203125
Related
pathway
ame04214  Apoptosis - fly
KO pathway
ko04013   
LinkDB

DBGET integrated database retrieval system