Entry
Name
Apoptosis - fly - Apis mellifera (honey bee)
Description
Apoptosis, or programmed cell death, is a critical factor in homeostasis in all multicellular organisms, playing a crucial role in removing excess unwanted cells without stimulation of an immune response. Caspases are the central components of the apoptotic response. In Drosophila, Dark promotes activation of the initiator caspase Dronc. Drosophila inhibitor of apoptosis protein 1 (DIAP1) inhibits Dronc and the effector caspases Drice and Dcp-1. RHG family proteins such as Rpr, Hid, Grim, Sickle, and Jafrac-2 promote cell death, in part by disrupting DIAP1's ability to inhibit caspase activity. Proapoptotic proteins such as caspases and RHG proteins are regulated through multiple pathways. The Drosophila steroid hormone ecdysone mediates cell death by controling the up-regulation of a number of proapoptotic genes. Cytotoxic stress such as DNA damage can activate P53, which in turn induces the expression of RHG genes. Eiger can initiate cell death through an IAP-sensitive cell death pathway via JNK signaling. Hid, a member of the RHG family, is negatively regulated by the epidermal growth factor (EGF) receptor-dependent survival signaling and positively regulated by the tumor suppressors Hippo, Salvador, and Warts.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
Ortholog table
Organism
Apis mellifera (honey bee) [GN:
ame ]
Gene
408521 Mblk-1; mushroom body large-type Kenyon cell-specific protein 1 [KO:K20015 ]
100578356 apoptotic protease-activating factor 1-like isoform X1 [KO:K02084 ]
411613 uncharacterized protein LOC411613 isoform X1 [KO:K20017 ]
410263 transmembrane GTPase Marf isoform X1 [KO:K06030 ] [EC:3.6.5.-]
412212 apoptosis-inducing factor 1, mitochondrial [KO:K04727 ] [EC:1.-.-.-]
725244 mitochondrial Rho GTPase isoform X1 [KO:K07870 ] [EC:3.6.5.-]
410226 activating transcription factor of chaperone isoform X2 [KO:K04374 ]
408979 eukaryotic translation initiation factor 5 [KO:K03262 ]
410208 serine/threonine-protein kinase 3 isoform X1 [KO:K04412 ]
408754 TNF receptor-associated factor 4 isoform X3 [KO:K09848 ]
726958 tumor necrosis factor receptor superfamily member wengen isoform X1 [KO:K16679 ]
726947 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K04404 ]
413389 dual specificity mitogen-activated protein kinase kinase hemipterous [KO:K04431 ] [EC:2.7.12.2 ]
Compound
Reference
Authors
Hay BA, Guo M
Title
Caspase-dependent cell death in Drosophila.
Journal
Reference
Authors
Hay BA, Huh JR, Guo M
Title
The genetics of cell death: approaches, insights and opportunities in Drosophila.
Journal
Reference
Authors
Kumar S, Cakouros D
Title
Transcriptional control of the core cell-death machinery.
Journal
Reference
Authors
Fuchs Y, Steller H
Title
Live to die another way: modes of programmed cell death and the signals emanating from dying cells.
Journal
Reference
Authors
Arya R, White K
Title
Cell death in development: Signaling pathways and core mechanisms.
Journal
Reference
Authors
Danial NN, Korsmeyer SJ
Title
Cell death: critical control points.
Journal
Reference
Authors
Gorski S, Marra M
Title
Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila.
Journal
Reference
Authors
Richardson H, Kumar S
Title
Death to flies: Drosophila as a model system to study programmed cell death.
Journal
Reference
Authors
Kuranaga E
Title
Caspase signaling in animal development.
Journal
Reference
Authors
Bergmann A, Steller H
Title
Apoptosis, stem cells, and tissue regeneration.
Journal
Reference
Authors
Riedl SJ, Shi Y
Title
Molecular mechanisms of caspase regulation during apoptosis.
Journal
Reference
Authors
Igaki T, Miura M
Title
Role of Bcl-2 family members in invertebrates.
Journal
Reference
Authors
Clavier A, Rincheval-Arnold A, Colin J, Mignotte B, Guenal I
Title
Apoptosis in Drosophila: which role for mitochondria?
Journal
Reference
Authors
Abdelwahid E, Rolland S, Teng X, Conradt B, Hardwick JM, White K
Title
Mitochondrial involvement in cell death of non-mammalian eukaryotes.
Journal
Reference
Authors
Demay Y, Perochon J, Szuplewski S, Mignotte B, Gaumer S
Title
The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model.
Journal
Reference
Authors
Kilpatrick ZE, Cakouros D, Kumar S
Title
Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells.
Journal
Reference
Authors
Yu SY, Yoo SJ, Yang L, Zapata C, Srinivasan A, Hay BA, Baker NE
Title
A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye.
Journal
Development 129:3269-78 (2002)
Reference
Authors
McNeill H, Downward J
Title
Apoptosis: Ras to the rescue in the fly eye.
Journal
Reference
Authors
Narasimamurthy R, Geuking P, Ingold K, Willen L, Schneider P, Basler K
Title
Structure-function analysis of Eiger, the Drosophila TNF homolog.
Journal
Reference
Authors
Liu B, Behura SK, Clem RJ, Schneemann A, Becnel J, Severson DW, Zhou L
Title
P53-mediated rapid induction of apoptosis conveys resistance to viral infection in Drosophila melanogaster.
Journal
Reference
Authors
Kuranaga E, Kanuka H, Igaki T, Sawamoto K, Ichijo H, Okano H, Miura M
Title
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.
Journal
Reference
Authors
Creagh EM, Brumatti G, Sheridan C, Duriez PJ, Taylor RC, Cullen SP, Adrain C, Martin SJ
Title
Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival.
Journal
Reference
Authors
Bilak A, Su TT
Title
Regulation of Drosophila melanogaster pro-apoptotic gene hid.
Journal
Related pathway
KO pathway
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