KEGG ORTHOLOGY: K02084

ORTHOLOGY: K02084

Entry

K02084                      KO

Symbol

APAF1

Name

apoptotic protease-activating factor

Pathway

map01524

Platinum drug resistance

map04115

p53 signaling pathway

map04210

Apoptosis

map04214

Apoptosis - fly

map04215

Apoptosis - multiple species

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05134

Legionellosis

map05152

Tuberculosis

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05164

Influenza A

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05200

Pathways in cancer

map05222

Small cell lung cancer

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02084  APAF1; apoptotic protease-activating factor
   04214 Apoptosis - fly
    K02084  APAF1; apoptotic protease-activating factor
   04215 Apoptosis - multiple species
    K02084  APAF1; apoptotic protease-activating factor
   04115 p53 signaling pathway
    K02084  APAF1; apoptotic protease-activating factor
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02084  APAF1; apoptotic protease-activating factor
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K02084  APAF1; apoptotic protease-activating factor
  09172 Infectious disease: viral
   05161 Hepatitis B
    K02084  APAF1; apoptotic protease-activating factor
   05160 Hepatitis C
    K02084  APAF1; apoptotic protease-activating factor
   05164 Influenza A
    K02084  APAF1; apoptotic protease-activating factor
   05162 Measles
    K02084  APAF1; apoptotic protease-activating factor
   05168 Herpes simplex virus 1 infection
    K02084  APAF1; apoptotic protease-activating factor
   05169 Epstein-Barr virus infection
    K02084  APAF1; apoptotic protease-activating factor
  09171 Infectious disease: bacterial
   05134 Legionellosis
    K02084  APAF1; apoptotic protease-activating factor
   05152 Tuberculosis
    K02084  APAF1; apoptotic protease-activating factor
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02084  APAF1; apoptotic protease-activating factor
   05012 Parkinson disease
    K02084  APAF1; apoptotic protease-activating factor
   05014 Amyotrophic lateral sclerosis
    K02084  APAF1; apoptotic protease-activating factor
   05016 Huntington disease
    K02084  APAF1; apoptotic protease-activating factor
   05020 Prion disease
    K02084  APAF1; apoptotic protease-activating factor
   05022 Pathways of neurodegeneration - multiple diseases
    K02084  APAF1; apoptotic protease-activating factor
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K02084  APAF1; apoptotic protease-activating factor
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K02084  APAF1; apoptotic protease-activating factor

Genes

HSA:	317(APAF1)

PTR:	452153(APAF1)

PPS:	100995524(APAF1)

GGO:	101135722(APAF1)

PON:	100459074(APAF1)

PPYG:

129009406(APAF1)

NLE:	100590369(APAF1)

HMH:	116479141(APAF1)

SSYN:

129460587(APAF1)

MCC:	694164(APAF1)

MCF:	102137473(APAF1)

MTHB:

126931282

MNI:	105463369(APAF1)

CSAB:

103238923(APAF1)

CATY:

105573341(APAF1)

PANU:

101023208(APAF1)

TGE:	112634060(APAF1)

MLEU:

105548296(APAF1)

RRO:	104656342(APAF1)

RBB:	108543462(APAF1)

TFN:	117089565(APAF1)

PTEH:

111520510(APAF1)

CANG:

105506411(APAF1)

CJC:	100403825(APAF1)

SBQ:	101048222(APAF1)

CIMI:

108290860(APAF1)

ANAN:

105728869(APAF1)

CSYR:

103251017(APAF1)

MMUR:

105883940(APAF1)

LCAT:

123639404(APAF1)

PCOQ:

105826075(APAF1)

OGA:	100959812(APAF1)

MMU:	11783(Apaf1)

MCAL:

110302801(Apaf1)

MPAH:

110326877(Apaf1)

RNO:	78963(Apaf1)

MCOC:

116075741(Apaf1)

ANU:	117696384(Apaf1)

ASYL:

127671244(Apaf1)

MUN:	110541243(Apaf1)

CGE:

100758500

MAUA:

101832699(Apaf1)

PROB:

127237866(Apaf1)

PLEU:

114700550(Apaf1)

MORG:

121462949(Apaf1)

MFOT:

126503758

AAMP:

119803346(Apaf1)

NGI:	103733246(Apaf1)

HGL:	101706721(Apaf1)

CPOC:

100719903(Apaf1)

CCAN:

109690039(Apaf1)

DORD:

105987659(Apaf1)

DSP:	122119240(Apaf1)

PLOP:

125359761(Apaf1)

NCAR:

124982341

MMMA:

107139684(Apaf1)

ITI:	101954329(Apaf1)

OCU:

103348383

OPI:	101517311(APAF1)

TUP:	102476798(APAF1)

GVR:	103590490(APAF1)

CFA:	482620(APAF1)

CLUD:

112654697(APAF1)

VVP:	112930669(APAF1)

VLG:	121481178(APAF1)

NPO:	129516890(APAF1)

AML:	100464163(APAF1)

UMR:	103660136(APAF1)

UAH:	113256111(APAF1)

UAR:	123780504(APAF1)

ELK:

111142091

LLV:

125106261

MPUF:

101691091(APAF1)

MNP:	132019338(APAF1)

MLK:	131839300(APAF1)

NVS:	122892476(APAF1)

ORO:	101383104(APAF1)

EJU:	114222925(APAF1)

ZCA:	113921409(APAF1)

MLX:	117998841(APAF1)

LWW:	102729908(APAF1)

FCA:	768257(APAF1)

PYU:	121040562(APAF1)

PCOO:

112863492(APAF1)

PBG:	122472567(APAF1)

PVIV:

125170378(APAF1)

LRUF:

124502711

LGF:	123591125(APAF1)

AJU:

106973746

PTG:	102964536(APAF1)

PPAD:

109265383(APAF1)

PUC:

125919454

PLEZ:

122224972(APAF1)

HHV:	120225026(APAF1)

BTA:	537782(APAF1)

BOM:	102285660(APAF1)

BIU:	109559418(APAF1)

BBUB:

102396152(APAF1)

BBIS:

104982240(APAF1)

CHX:	102188830(APAF1)

OAS:	100135699(APAF1)

BTAX:

128048021(APAF1)

CSUM:

138078458(APAF1)

ODA:	120858692(APAF1)

CCAD:

122423286(APAF1)

MREE:

136169534(APAF1)

OVR:	110148292(APAF1)

MBEZ:

129535887(APAF1)

SSC:	100513283(APAF1)

CFR:	102516966(APAF1)

CBAI:

105075026(APAF1)

CDK:	105097442(APAF1)

VPC:	102538116(APAF1)

BACU:

103006029(APAF1)

BMUS:

118901894(APAF1)

LVE:	103069785(APAF1)

OOR:	101280303(APAF1)

LALB:

132528654(APAF1)

DLE:	111187821(APAF1)

PCAD:

102994125(APAF1)

PSIU:

116760585(APAF1)

NASI:

112409026(APAF1)

ECB:	100052552(APAF1)

EPZ:	103550811(APAF1)

EAI:	106827252(APAF1)

MYB:	102242936(APAF1)

MYD:	102773861(APAF1)

MMYO:

118650180(APAF1)

MLF:	102435183(APAF1)

MDT:	132227137(APAF1)

MYUM:

139007440(APAF1)

PKL:	118729137(APAF1)

EFUS:

103289111(APAF1)

MNA:	107545129(APAF1)

DRO:	112321814(APAF1)

SHON:

119002556(APAF1)

AJM:	119060513(APAF1)

PDIC:

114512815(APAF1)

PHAS:

123810711(APAF1)

MMF:	118623170(APAF1)

PPAM:

129071395(APAF1)

HAI:	109382336(APAF1)

RFQ:	117029090(APAF1)

PALE:

102897687(APAF1)

PGIG:

120611595(APAF1)

PVP:	105288270(APAF1)

RAY:	107517482(APAF1)

MJV:	108406748(APAF1)

TOD:	119248206(APAF1)

SARA:

101537432(APAF1)

SFUM:

130023768(APAF1)

SETR:

126021976(APAF1)

LAV:	100665091(APAF1)

TMU:

101349393

ETF:	101656765(APAF1)

DNM:	101432735(APAF1)

MDO:	100013051(APAF1)

GAS:	123250560(APAF1)

SHR:	100932636(APAF1)

AFZ:

127564838

PCW:	110221734(APAF1)

TVP:	118852280(APAF1)

PBRV:

138166587(APAF1)

OAA:	100073402(APAF1)

TACU:

119936780(APAF1)

GGA:	417926(APAF1)

PCOC:

116233475(APAF1)

MGP:	100549497(APAF1)

CJO:	107311930(APAF1)

TPAI:

128073067(APAF1)

LMUT:

125688057(APAF1)

NMEL:

110403055(APAF1)

APLA:

101799443(APAF1)

ACYG:

106036949(APAF1)

CATA:

118250544(APAF1)

AFUL:

116497506(APAF1)

TGU:	100222477(APAF1)

LSR:	110469328(APAF1)

SCAN:

103813383(APAF1)

PMOA:

120499830(APAF1)

OTC:	121338615(APAF1)

PRUF:

121357189(APAF1)

ATRC:

139588176(APAF1)

GFR:	102039129(APAF1)

FAB:	101817511(APAF1)

OMA:	130266186(APAF1)

PHI:	102103178(APAF1)

PMAJ:

107204470(APAF1)

CCAE:

111933973(APAF1)

CCW:	104696424(APAF1)

CBRC:

103618173(APAF1)

ACOE:

138102804(APAF1)

ETL:	114065277(APAF1)

ZAB:	102069090(APAF1)

ZLE:	135442374(APAF1)

ACHL:

103809159(APAF1)

SVG:	106861312(APAF1)

MMEA:

130585402(APAF1)

HRT:	120751426(APAF1)

SATI:

136361427(APAF1)

CCIC:

134043702(APAF1)

FPG:	101911538(APAF1)

FCH:	102046505(APAF1)

CCRI:

104166839(APAF1)

NNT:	104412664(APAF1)

SHAB:

115605784(APAF1)

ACUN:

113491382(APAF1)

TALA:

104368355(APAF1)

ACHC:

115336106(APAF1)

HALD:

104314532(APAF1)

HLE:	104828305(APAF1)

AGEN:

126034566

HHAR:

128135370(APAF1)

GCL:

127015789

CSTI:

104549324

LDI:	104352978(APAF1)

MNB:

103773007

DPUB:

104308028(APAF1)

PPUS:

135181687(APAF1)

AVIT:

104277130

EGZ:	104132316(APAF1)

NNI:	104011661(APAF1)

PCRI:

104036594

PCAO:

104039353(APAF1)

PADL:

103914625(APAF1)

AFOR:

103895153(APAF1)

FGA:	104078519(APAF1)

GSTE:

104255295(APAF1)

CLV:	102095228(APAF1)

MUI:	104545162(APAF1)

PGUU:

104457451(APAF1)

PLET:

104617425(APAF1)

EHS:	104502424(APAF1)

CMAC:

104482640(APAF1)

CUCA:

104055179(APAF1)

TEO:	104375931(APAF1)

BREG:

104637858(APAF1)

OHA:	104334484(APAF1)

ACAR:

104517426(APAF1)

CPEA:

104397996(APAF1)

CVF:	104284312(APAF1)

RTD:	128904449(APAF1)

CRID:

134509999(APAF1)

AAM:	106488625(APAF1)

AROW:

112974840(APAF1)

NPD:	112959481(APAF1)

TGT:	104573948(APAF1)

DNE:	112997264(APAF1)

SCAM:

104143811(APAF1)

ASN:	102371819(APAF1)

AMJ:	102560580(APAF1)

CPOO:

109316780(APAF1)

GGN:	109295891(APAF1)

PSS:	102451576(APAF1)

CMY:	102940699(APAF1)

CCAY:

125630055(APAF1)

DCC:	119850062(APAF1)

CPIC:

101942057(APAF1)

TST:	117880527(APAF1)

CABI:

116829637(APAF1)

MRV:	120374768(APAF1)

ACS:	100556318(apaf1)

ASAO:

132776065(APAF1)

PVT:	110084192(APAF1)

SUND:

121931976(APAF1)

PBI:	103057709(APAF1)

PMUR:

107290550(APAF1)

CTIG:

120312825(APAF1)

TSR:

106547253

PGUT:

117655913(APAF1)

APRI:

131202060(APAF1)

PTEX:

113434759(APAF1)

NSS:	113431849(APAF1)

VKO:	123035998(APAF1)

PMUA:

114605383(APAF1)

PRAF:

128422563(APAF1)

ZVI:	118090760(APAF1)

HCG:	128328158(APAF1)

GJA:	107118861(APAF1)

STOW:

125440073(APAF1)

EMC:	129336555(APAF1)

XLA:	444261(apaf1.L)

XTR:	100127738(apaf1)

NPR:	108798110(APAF1)

RTEM:

120932156(APAF1)

BBUF:

120978714(APAF1)

BGAR:

122928123(APAF1)

PWL:

138286693

MUO:	115477892(APAF1)

GSH:	117363523(APAF1)

DRE:	58131(apaf1)

SRX:	107725574(apaf1) 107744928

SANH:

107664840 107695885(apaf1)

SGH:	107576429 107593638(apaf1)

CCAR:

109078713

CAUA:

113062586(apaf1)

CGIB:

127956552

PTET:

122342892(apaf1)

OMC:	131539000(apaf1)

PPRM:

120477013(apaf1)

RKG:	130072227(apaf1)

MAMB:

125244334(apaf1)

CIDE:

127510875

CERY:

137024447(apaf1)

MASI:

127435133 127436881

TROS:

130547813(apaf1)

TDW:	130420604(apaf1)

MANU:

129432365(apaf1)

PDAB:

135749773 135774850

IPU:

108274767

IFU:	128617976(apaf1)

PHYP:

113529624(apaf1)

SMEO:

124392742(apaf1)

TFD:	113653907(apaf1)

TVC:	132856684(apaf1)

CGAR:

128507605(apaf1)

NGRA:

132881618(apaf1)

TRN:	134312312(apaf1)

AMEX:

103032437(apaf1)

CMAO:

118812026(apaf1)

EEE:	113576600 113591451

CHAR:

105900670(apaf1)

SPIL:

134062209(apaf1)

TRU:	101076369(apaf1)

TFS:	130519022(apaf1)

TNG:	GSTEN00020796G001

LCO:	104925081(apaf1)

NCC:	104967722(apaf1)

TBEN:

117484920(apaf1)

CGOB:

115028326(apaf1)

PGEO:

117468439(apaf1)

GACU:

117559145(apaf1)

EMAC:

134879160(apaf1)

ELY:	117249347(apaf1)

EFO:	125882693(apaf1)

PLEP:

121961175(apaf1)

SLUC:

116060011(apaf1)

ECRA:

117938437(apaf1)

ESP:	116672757(apaf1)

PFLV:

114550188(apaf1)

GAT:	120817649(apaf1)

PPUG:

119210336(apaf1)

AFB:	129112780(apaf1)

CLUM:

117726060(apaf1)

PSWI:

130200601(apaf1)

CANA:

137791861(apaf1)

CVE:	137877453(apaf1)

MSAM:

119918136(apaf1)

SCHU:

122871400(apaf1)

CUD:	121505365(apaf1)

SPUL:

138599337(apaf1)

LMIX:

132956378(apaf1)

ALAT:

119032660(apaf1)

ASTR:

137589179(apaf1)

MZE:	101470098(apaf1)

ONL:	100701636(apaf1)

OAU:	116334993(apaf1)

OLA:	101158654(apaf1)

OML:	112157788(apaf1)

XMA:	102220895(apaf1)

XCO:	114160921(apaf1)

XHE:	116736841(apaf1)

PRET:

103459197(apaf1)

PFOR:

103146229(apaf1)

PLAI:

106961846(apaf1)

PMEI:

106919213(apaf1)

GAF:	122826177(apaf1)

PPRL:

129375625(apaf1)

CVG:	107101831(apaf1)

CTUL:

119789345(apaf1)

GMU:	124882742(apaf1)

NFU:	107373731 107385893(apaf1)

KMR:	108233243(apaf1)

ALIM:

106514788(apaf1)

NWH:	119428301(apaf1)

AOCE:

111578144(apaf1)

EJA:	138207565(apaf1)

BFRE:

138631046(apaf1)

MCEP:

125000209(apaf1)

CSEM:

103382677(apaf1)

POV:	109632693(apaf1)

SSEN:

122762437(apaf1)

SSOE:

131456784(apaf1)

HHIP:

117757252(apaf1)

HSP:	118101364(apaf1)

PPLT:

128428724(apaf1)

SMAU:

118287947(apaf1)

LCF:

108889265

SDU:	111224851(apaf1)

SLAL:

111656499(apaf1)

XGL:	120801555(apaf1)

HCQ:	109523695(apaf1)

SSCV:

125992112(apaf1)

SBIA:

133493256(apaf1)

PEE:	133397335(apaf1)

PTAO:

133471744(apaf1)

BPEC:

110161643(apaf1)

ENY:	140368179(apaf1)

MALB:

109959862(apaf1)

BSPL:

114862601(apaf1)

SJO:	128353481(apaf1)

SSCO:

134004227(apaf1)

SASA:

106576445 106609566

STRU:

115180292 115199073

OTW:	112229243(apaf1) 112267804

OMY:	110490568 110499902

OGO:	123994384 124013654

ONE:	115107136(apaf1) 115132926

OKI:	109878550 109882975

OKE:	118378593 118380838

OMM:	135515072 135515717

OCLA:

139378446 139392681

SALP:

111955569 112072446

SNH:	120032288 120050085(apaf1)

CCLU:

121543432 121549496

ELS:	105020401(apaf1)

OEP:	134037516(apaf1)

SFM:	108931524(apaf1)

PKI:	111846556(apaf1)

AANG:

118231849(apaf1)

AROT:

135258962(apaf1)

CCOG:

133135677(apaf1)

LOC:	102694419(apaf1)

PSPA:

121318439 121319656

ARUT:

117416074 117419459

LCM:	102354670(APAF1)

CMK:	103187971(apaf1)

RTP:	109932240(apaf1)

CPLA:

122561666(apaf1)

HOC:	132826754(apaf1)

LERI:

129707730(apaf1)

PMRN:

116943734(APAF1)

LRJ:	133355551(APAF1)

BFO:

118419621

BBEL:

109467951

SPU:	100887910 100892760 591503

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DME:	Dmel_CG6829(Dark)

DER:

6548165

DSE:

6609536

DSI:	Dsimw501_GD11239(Dsim_GD11239)

DYA:	Dyak_GE11637

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21338

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

AOQ:

ALUD:

TDA:	119674473 119681192

MDE:

101889170

SCAC:

106093859 106093860 106094912

LCQ:

111684219

LSQ:

119610488

CVJ:	135959997(Dark)

GFS:

ECOE:

CLON:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ002803

CPII:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:	105672289(Dark)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

TMOL:

138135014(Dark)

SOY:	115886200 115886737

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100529085(Apaf-1)

BMAN:

MSEX:

PMAC:

PPOT:

PXU:

BPHI:

137918444(Dark)

HAW:

HZE:

TNL:

SLIU:

ONU:

ATRA:

GMW:

PXY:

LGLY:

CSTB:

API:

DNX:

AGS:

RMD:

DVT:

CLEC:

HHAL:

106684447(Dark)

NLU:

HVI:

MQU:

FOC:

TPAL:

ZNE:

CSEC:

FCD:

DPX:	DAPPUDRAFT_226784

DMK:

DPZ:

AFRA:

EAF:

PPOI:

DSV:

RSAN:

RMP:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

TSP:

OVI:	T265_06260

LLON:

135494150

NVE:

5519825

EPA:	110233758 110233767

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130612275 130662642

RES:	135693033 135695346

AQU:

105313814

» show all

Reference

PMID:9267021

Authors

Zou H, Henzel WJ, Liu X, Lutschg A, Wang X

Title

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.

Journal

Cell 90:405-13 (1997)
DOI:10.1016/S0092-8674(00)80501-2

Sequence

[hsa:317]

Reference

PMID:11859117

Authors

Hara H, Takeda A, Takeuchi M, Wakeham AC, Itie A, Sasaki M, Mak TW, Yoshimura A, Nomoto K, Yoshida H

Title

The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.

Journal

J Immunol 168:2288-95 (2002)
DOI:10.4049/jimmunol.168.5.2288

Sequence

[mmu:11783]

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