KEGG   PATHWAY: amus00260
Entry
amus00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Akanthomyces muscarius
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
amus00260  Glycine, serine and threonine metabolism
amus00260

Module
amus_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:amus00260]
amus_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:amus00260]
amus_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:amus00260]
amus_M00621  Glycine cleavage system [PATH:amus00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Akanthomyces muscarius [GN:amus]
Gene
LMH87_004574  hypothetical protein [KO:K00928] [EC:2.7.2.4]
LMH87_007864  uncharacterized protein [KO:K00928] [EC:2.7.2.4]
LMH87_002351  hypothetical protein [KO:K00133] [EC:1.2.1.11]
LMH87_000592  hypothetical protein [KO:K00003] [EC:1.1.1.3]
LMH87_007896  uncharacterized protein [KO:K00872] [EC:2.7.1.39]
LMH87_000274  hypothetical protein [KO:K01733] [EC:4.2.3.1]
LMH87_002777  hypothetical protein [KO:K01620] [EC:4.1.2.48]
LMH87_009961  hypothetical protein [KO:K01620] [EC:4.1.2.48]
LMH87_000034  hypothetical protein [KO:K01620] [EC:4.1.2.48]
LMH87_005622  hypothetical protein [KO:K00600] [EC:2.1.2.1]
LMH87_000978  hypothetical protein [KO:K00600] [EC:2.1.2.1]
LMH87_000425  hypothetical protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
LMH87_001348  hypothetical protein [KO:K01834] [EC:5.4.2.11]
LMH87_005442  hypothetical protein [KO:K15633] [EC:5.4.2.12]
LMH87_006378  hypothetical protein [KO:K15918] [EC:2.7.1.31]
LMH87_004529  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LMH87_010980  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LMH87_002799  hypothetical protein [KO:K00831] [EC:2.6.1.52]
LMH87_010426  hypothetical protein [KO:K01079] [EC:3.1.3.3]
LMH87_000665  hypothetical protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
LMH87_004188  hypothetical protein [KO:K00643] [EC:2.3.1.37]
LMH87_006457  hypothetical protein [KO:K00274] [EC:1.4.3.4]
LMH87_010726  hypothetical protein [KO:K00274] [EC:1.4.3.4]
LMH87_007774  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
LMH87_011231  hypothetical protein [KO:K00276] [EC:1.4.3.21]
LMH87_012082  hypothetical protein [KO:K00276] [EC:1.4.3.21]
LMH87_008789  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
LMH87_010383  hypothetical protein [KO:K00281] [EC:1.4.4.2]
LMH87_007204  hypothetical protein [KO:K00605] [EC:2.1.2.10]
LMH87_005806  hypothetical protein [KO:K00382] [EC:1.8.1.4]
LMH87_010875  hypothetical protein [KO:K02437]
LMH87_011170  hypothetical protein [KO:K00273] [EC:1.4.3.3]
LMH87_012270  hypothetical protein [KO:K00273] [EC:1.4.3.3]
LMH87_007426  hypothetical protein [KO:K00613] [EC:2.1.4.1]
LMH87_001736  hypothetical protein [KO:K00613] [EC:2.1.4.1]
LMH87_009183  uncharacterized protein [KO:K00613] [EC:2.1.4.1]
LMH87_005212  hypothetical protein [KO:K00613] [EC:2.1.4.1]
LMH87_005832  hypothetical protein [KO:K17103] [EC:2.7.8.8]
LMH87_003382  hypothetical protein [KO:K00130] [EC:1.2.1.8]
LMH87_010702  hypothetical protein [KO:K00309] [EC:1.5.3.10]
LMH87_009065  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
LMH87_005597  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
LMH87_008325  uncharacterized protein [KO:K01697] [EC:4.2.1.22]
LMH87_011530  hypothetical protein [KO:K01758] [EC:4.4.1.1]
LMH87_006752  hypothetical protein [KO:K01754] [EC:4.3.1.19]
LMH87_004879  hypothetical protein [KO:K01754] [EC:4.3.1.19]
LMH87_002779  hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
LMH87_004353  hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
LMH87_011436  hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
LMH87_009824  hypothetical protein [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
amus00010  Glycolysis / Gluconeogenesis
amus00020  Citrate cycle (TCA cycle)
amus00230  Purine metabolism
amus00250  Alanine, aspartate and glutamate metabolism
amus00270  Cysteine and methionine metabolism
amus00290  Valine, leucine and isoleucine biosynthesis
amus00300  Lysine biosynthesis
amus00330  Arginine and proline metabolism
amus00460  Cyanoamino acid metabolism
amus00470  D-Amino acid metabolism
amus00564  Glycerophospholipid metabolism
amus00600  Sphingolipid metabolism
amus00620  Pyruvate metabolism
amus00630  Glyoxylate and dicarboxylate metabolism
amus00640  Propanoate metabolism
amus00680  Methane metabolism
amus00860  Porphyrin metabolism
amus00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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