KEGG   PATHWAY: anu00982
Entry
anu00982                    Pathway                                
Name
Drug metabolism - cytochrome P450 - Arvicanthis niloticus (African grass rat)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
anu00982  Drug metabolism - cytochrome P450
anu00982

Organism
Arvicanthis niloticus (African grass rat) [GN:anu]
Gene
117716175  Fmo1; dimethylaniline monooxygenase [N-oxide-forming] 1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
117716244  dimethylaniline monooxygenase [N-oxide-forming] 3 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
117716328  dimethylaniline monooxygenase [N-oxide-forming] 5-like isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
117716345  putative dimethylaniline monooxygenase [N-oxide-forming] 6 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
117716357  Fmo4; dimethylaniline monooxygenase [N-oxide-forming] 4 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
117706608  Fmo5; dimethylaniline monooxygenase [N-oxide-forming] 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
117716477  dimethylaniline monooxygenase [N-oxide-forming] 5-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
117716489  dimethylaniline monooxygenase [N-oxide-forming] 5-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
117716626  Fmo2; dimethylaniline monooxygenase [N-oxide-forming] 2 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
117704700  Gsto2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
117704706  Gsto1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
117722371  glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
117722373  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
117722423  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
117722532  glutathione S-transferase alpha-3 [KO:K00799] [EC:2.5.1.18]
117715441  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
117722661  glutathione S-transferase A6 [KO:K00799] [EC:2.5.1.18]
117712654  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
117712712  glutathione S-transferase alpha-2-like [KO:K00799] [EC:2.5.1.18]
117716150  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
117706587  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
117706588  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
117706589  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
117706590  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
117706591  glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
117706595  Gstm4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
117724528  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
117724531  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
117724532  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
117707482  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
117724949  glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
117707765  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
117712791  glutathione S-transferase alpha-2 [KO:K00799] [EC:2.5.1.18]
117722448  glutathione S-transferase P 2-like [KO:K23790] [EC:2.5.1.18]
117698262  glutathione S-transferase P 1 [KO:K23790] [EC:2.5.1.18]
117698288  glutathione S-transferase P 1 isoform X1 [KO:K23790] [EC:2.5.1.18]
117720334  glutathione S-transferase kappa 1-like isoform X1 [KO:K13299] [EC:2.5.1.18]
117720353  glutathione S-transferase kappa 1 isoform X1 [KO:K13299] [EC:2.5.1.18]
117715576  Hpgds; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
117706919  Adh7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 [KO:K13951] [EC:1.1.1.1]
117707710  alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
117707173  all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
117707293  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
117707512  alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
117699232  Aldh3b1; aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
117719884  aldehyde dehydrogenase family 3 member B3 [KO:K00129] [EC:1.2.1.5]
117710473  Aldh3a1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
117714070  aldehyde dehydrogenase family 3 member B2 [KO:K00129] [EC:1.2.1.5]
117694748  Maoa; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
117695517  Maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
117705354  aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
117705706  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
117705708  aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
117706200  aldehyde oxidase 3 isoform X1 [KO:K00157] [EC:1.2.3.1]
117722348  UDP-glucuronosyltransferase 1-5-like [KO:K00699] [EC:2.4.1.17]
117722698  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
117722699  UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
117722733  UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
117722735  UDP-glucuronosyltransferase 1-1 isoform X1 [KO:K00699] [EC:2.4.1.17]
117722736  UDP-glucuronosyltransferase 1-5-like [KO:K00699] [EC:2.4.1.17]
117712352  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
117712566  UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
117712567  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
117712689  UDP-glucuronosyltransferase 2B17 isoform X1 [KO:K00699] [EC:2.4.1.17]
117712751  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
117712771  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
117712815  UDP-glucuronosyltransferase 2B1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
117712837  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
117712845  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
117712855  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
117698970  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
117715822  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
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