KEGG   PATHWAY: aof04148
Entry
aof04148                    Pathway                                
Name
Efferocytosis - Asparagus officinalis (garden asparagus)
Class
Cellular Processes; Transport and catabolism
Pathway map
aof04148  Efferocytosis
aof04148

Organism
Asparagus officinalis (garden asparagus) [GN:aof]
Gene
109829982  sphingosine kinase 1-like isoform X1 [KO:K04718] [EC:2.7.1.91]
109849533  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
109829965  mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109833144  calcium-transporting ATPase 3, endoplasmic reticulum-type isoform X1 [KO:K05853] [EC:7.2.2.10]
109843486  protein-tyrosine-phosphatase IBR5-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109838717  protein-tyrosine-phosphatase IBR5-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109848299  LOW QUALITY PROTEIN: phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
109851217  phospholipid-transporting ATPase 3 isoform X1 [KO:K14802] [EC:7.6.2.1]
109848163  phospholipid-transporting ATPase 1 [KO:K14802] [EC:7.6.2.1]
109842861  phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
109845182  putative ALA-interacting subunit 2 [KO:K26935]
109844627  ALA-interacting subunit 1-like [KO:K26935]
109820568  ALA-interacting subunit 1-like [KO:K26935]
109825499  rac-like GTP-binding protein 5 [KO:K04392]
109829261  rac-like GTP-binding protein RAC2 [KO:K04392]
109840336  rac-like GTP-binding protein 3 isoform X1 [KO:K04392]
109851044  rac-like GTP-binding protein ARAC5 [KO:K04392]
109821820  rac-like GTP-binding protein 5 [KO:K04392]
109839941  rac-like GTP-binding protein 2 [KO:K04392]
109822258  rac-like GTP-binding protein RAC2 [KO:K04392]
109849666  rac-like GTP-binding protein 3 isoform X1 [KO:K04392]
109837701  rac-like GTP-binding protein 5 [KO:K04392]
109846813  rac-like GTP-binding protein 2 [KO:K04392]
109824789  calreticulin-3-like [KO:K08057]
109843264  calreticulin-like [KO:K08057]
109837575  calreticulin-3-like [KO:K08057]
109819799  calreticulin-like [KO:K08057]
109819801  calreticulin-like [KO:K08057]
109822713  ras-related protein RHN1-like [KO:K07888]
109819648  ras-related protein RABF2b-like isoform X1 [KO:K07889]
109825720  ras-related protein Rab5 [KO:K07889]
109836684  ras-related protein RHN1-like [KO:K07889]
109834956  vam6/Vps39-like protein [KO:K20177]
109850214  vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
109834241  vacuolar protein-sorting-associated protein 11 homolog [KO:K20179]
109840795  protein VACUOLELESS1 [KO:K20180]
109851462  vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
109837528  vacuolar protein-sorting-associated protein 33 homolog [KO:K20182]
109822968  LOW QUALITY PROTEIN: vam6/Vps39-like protein [KO:K20183]
109835782  vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
109846278  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
109827908  ras-related protein Rab7-like [KO:K07897]
109828020  ras-related protein Rab7-like isoform X1 [KO:K07897]
109822270  ras-related protein Rab7-like isoform X1 [KO:K07897]
109850158  ras-related protein Rab7 [KO:K07897]
109828168  probable vacuolar amino acid transporter YPQ1 [KO:K23678]
109851415  probable vacuolar amino acid transporter YPQ1 [KO:K23678]
109843185  probable vacuolar amino acid transporter YPQ1 [KO:K23678]
109819554  seven transmembrane protein 1-like isoform X1 [KO:K23678]
109837781  arginase 1, mitochondrial [KO:K01476] [EC:3.5.3.1]
109828741  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
109839001  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
109839022  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
109831488  cytochrome b-c1 complex subunit Rieske-4, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
109823545  cytochrome b-c1 complex subunit Rieske-4, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
109837382  cytochrome b-c1 complex subunit Rieske-4, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
109841591  LOW QUALITY PROTEIN: triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
109837214  triacylglycerol lipase 2 [KO:K01052] [EC:3.1.1.13]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
aof00010  Glycolysis / Gluconeogenesis
aof04145  Phagosome
KO pathway
ko04148   
LinkDB

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