KEGG   PATHWAY: aprc00053
Entry
aprc00053                   Pathway                                
Name
Ascorbate and aldarate metabolism - Abrus precatorius (Indian licorice)
Class
Metabolism; Carbohydrate metabolism
Pathway map
aprc00053  Ascorbate and aldarate metabolism
aprc00053

Module
aprc_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:aprc00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Abrus precatorius (Indian licorice) [GN:aprc]
Gene
113846650  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
113858243  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
113862721  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
113867089  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
113868600  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
113869536  UDP-sugar pyrophosphorylase 1 [KO:K12447] [EC:2.7.7.64]
113866512  glucuronokinase 1-like isoform X1 [KO:K16190] [EC:2.7.1.43]
113849014  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
113854167  inositol oxygenase 4-like isoform X1 [KO:K00469] [EC:1.13.99.1]
113855772  inositol oxygenase 2-like [KO:K00469] [EC:1.13.99.1]
113860153  NADPH-dependent aldo-keto reductase, chloroplastic-like isoform X1 [KO:K00002] [EC:1.1.1.2]
113849306  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
113849389  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
113862633  NADPH-dependent aldo-keto reductase, chloroplastic-like isoform X1 [KO:K00002] [EC:1.1.1.2]
113862958  NADPH-dependent aldo-keto reductase, chloroplastic-like [KO:K00002] [EC:1.1.1.2]
113863816  aldose reductase [KO:K00002] [EC:1.1.1.2]
113847457  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
113862093  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
113863005  probable L-gulonolactone oxidase 6 isoform X1 [KO:K00103] [EC:1.1.3.8]
113851070  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
113871018  GDP-mannose 3,5-epimerase [KO:K10046] [EC:5.1.3.18 5.1.3.-]
113861202  GDP-mannose 3,5-epimerase 2 isoform X1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
113848427  GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
113854098  GDP-L-galactose phosphorylase 1-like [KO:K14190] [EC:2.7.7.69]
113846571  inositol monophosphatase 3-like isoform X1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
113872664  inositol-phosphate phosphatase-like isoform X1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
113864744  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
113858444  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
113871303  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
113849052  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
113849752  UDP-glucuronate 4-epimerase 5 [KO:K08679] [EC:5.1.3.6]
113849118  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
113864932  UDP-glucuronate 4-epimerase 4-like [KO:K08679] [EC:5.1.3.6]
113869128  UDP-glucuronate 4-epimerase 5-like [KO:K08679] [EC:5.1.3.6]
113846282  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
113861690  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
113873469  monodehydroascorbate reductase isoform X1 [KO:K08232] [EC:1.6.5.4]
113853900  monodehydroascorbate reductase, chloroplastic/mitochondrial isoform X1 [KO:K08232] [EC:1.6.5.4]
113859214  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
113864980  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
113866037  L-ascorbate peroxidase 3 isoform X1 [KO:K00434] [EC:1.11.1.11]
113866932  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
113868726  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
113872224  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
113849681  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
113859049  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
113859083  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
113849073  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
113855822  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
113846395  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
113858057  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
113858445  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
113849627  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
113852533  aldehyde dehydrogenase family 3 member H1-like [KO:K00128] [EC:1.2.1.3]
113865157  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
113853137  aldehyde dehydrogenase family 2 member B4, mitochondrial-like isoform X1 [KO:K00128] [EC:1.2.1.3]
113854044  aldehyde dehydrogenase family 3 member H1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
113868887  aldehyde dehydrogenase family 2 member B7, mitochondrial-like isoform X1 [KO:K00128] [EC:1.2.1.3]
113846165  aldehyde dehydrogenase family 3 member H1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
113857715  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
113866383  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
aprc00020  Citrate cycle (TCA cycle)
aprc00040  Pentose and glucuronate interconversions
aprc00051  Fructose and mannose metabolism
aprc00520  Amino sugar and nucleotide sugar metabolism
aprc00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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