KEGG PATHWAY: bbif04013

KEGG

PATHWAY: bbif04013

Entry

bbif04013                   Pathway

Name

MAPK signaling pathway - fly - Bombus bifarius (two-form bumblebee)

Description

The mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role in mitosis, apoptosis, motility and metabolism. In fruit fly, three major classes of MAPK pathways have been distinguished with little or no redundancy, including extracellular signal-regulated kinase (ERK) / Rolled, c-Jun N-terminal kinase (JNK) / Bsk, and p38 kinase. Signals from growth factors or mitogens are dominantly transduced by the ERK pathway, whereas the JNK and p38 pathways are activated mostly by environmental stresses. The MAPK signaling cascades are typically linked to regulation of gene expression, because transcription factors are often the targets of regulatory phosphorylation events.

Class

Environmental Information Processing; Signal transduction

Pathway map

MAPK signaling pathway - fly

Other DBs

GO:

Organism

Bombus bifarius (two-form bumblebee) [GN:bbif]

Gene

torso-like protein [KO:K12377]

uncharacterized protein LOC117211562 [KO:K20227]

uncharacterized protein LOC117204679 [KO:K20228]

protein giant-lens isoform X1 [KO:K02104]

protein vein isoform X1 [KO:K16690]

epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]

leucine-rich repeat-containing protein 24-like [KO:K20230]

protein bride of sevenless isoform X1 [KO:K04623]

proto-oncogene tyrosine-protein kinase ROS isoform X1 [KO:K05088] [EC:2.7.10.1]

SHC-transforming protein 1 [KO:K06279]

protein enhancer of sevenless 2B [KO:K04364]

GRB2-associated-binding protein 2 isoform X1 [KO:K20231]

tyrosine-protein phosphatase corkscrew isoform X1 [KO:K07293] [EC:3.1.3.48]

protein son of sevenless isoform X1 [KO:K03099]

ras-like protein 1 [KO:K07827]

ras GTPase-activating protein 1 isoform X1 [KO:K04352]

ras GTPase-activating protein 3 isoform X1 [KO:K12380]

raf homolog serine/threonine-protein kinase Raf [KO:K04365] [EC:2.7.11.1]

14-3-3 protein zeta isoform X1 [KO:K16197]

serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]

kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]

dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]

mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]

importin-7 [KO:K20223]

putative transcription factor capicua isoform X1 [KO:K20225]

nuclear receptor subfamily 2 group E member 1 [KO:K08545]

protein groucho-like isoform X1 [KO:K04497]

protein groucho-like [KO:K04497]

protein groucho isoform X1 [KO:K04497]

zinc finger protein 2-like [KO:K12379]

ETS-like protein pointed isoform X1 [KO:K02678]

ets DNA-binding protein pokkuri-like [KO:K03211]

exportin-1 [KO:K14290]

protein tramtrack, alpha isoform isoform X1 [KO:K09237]

E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]

F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]

ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]

runt-related transcription factor 3-like isoform X1 [KO:K20214]

homeobox protein prospero-like isoform X1 [KO:K20211]

protein eiger-like isoform X1 [KO:K16678]

tumor necrosis factor receptor superfamily member wengen [KO:K16679]

docking protein 1 [KO:K20234]

tyrosine-protein kinase Src42A isoform X1 [KO:K08892] [EC:2.7.10.2]

tyrosine-protein kinase Src64B isoform X1 [KO:K05704] [EC:2.7.10.2]

tyrosine-protein kinase Btk29A isoform X1 [KO:K07364] [EC:2.7.10.2]

serine/threonine-protein kinase mig-15 isoform X1 [KO:K08840] [EC:2.7.11.1]

ras-related C3 botulinum toxin substrate 1 [KO:K04392]

ras-like GTP-binding protein RhoL [KO:K04392]

ras-related protein Rac1 [KO:K04392]

TNF receptor-associated factor 6-like isoform X1 [KO:K03175] [EC:2.3.2.27]

ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]

mitogen-activated protein kinase kinase kinase 10-like isoform X1 [KO:K04417] [EC:2.7.11.25]

mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]

protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]

dual specificity mitogen-activated protein kinase kinase hemipterous-like [KO:K04431] [EC:2.7.12.2]

dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]

stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]

striatin [KO:K17608]

transcription factor AP-1 [KO:K04448]

transcription factor kayak [KO:K09031]

ras-responsive element-binding protein 1 [KO:K20210]

uncharacterized protein LOC117216896 isoform X1 [KO:K20235]

protein decapentaplegic-like [KO:K04662]

profilin [KO:K05759]

dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]

bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]

mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]

mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]

dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04432] [EC:2.7.12.2]

mitogen-activated protein kinase p38b-like isoform X1 [KO:K04441] [EC:2.7.11.24]

cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]

dual oxidase isoform X1 [KO:K13411] [EC:1.6.3.1 1.11.1.-]

optomotor-blind protein isoform X1 [KO:K10176]

myocyte-specific enhancer factor 2 isoform X1 [KO:K09260]

superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]

Reference

Authors

Sopko R, Perrimon N

Title

Receptor tyrosine kinases in Drosophila development.

Journal

Cold Spring Harb Perspect Biol 5:a009050 (2013)
DOI:10.1101/cshperspect.a009050

Reference

Authors

Li WX

Title

Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.

Journal

Dev Dyn 232:656-72 (2005)
DOI:10.1002/dvdy.20295

Reference

Authors

Shilo BZ

Title

Signaling by the Drosophila epidermal growth factor receptor pathway during development.

Journal

Exp Cell Res 284:140-9 (2003)
DOI:10.1016/S0014-4827(02)00094-0

Reference

Authors

Raabe T

Title

The sevenless signaling pathway: variations of a common theme.

Journal

Biochim Biophys Acta 1496:151-63 (2000)
DOI:10.1016/S0167-4889(00)00020-3

Reference

Authors

Rios-Barrera LD, Riesgo-Escovar JR

Title

Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway.

Journal

Genesis 51:147-62 (2013)
DOI:10.1002/dvg.22354

Reference

Authors

Igaki T, Miura M

Title

The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.

Journal

Semin Immunol 26:267-74 (2014)
DOI:10.1016/j.smim.2014.05.003

Reference

Authors

Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX

Title

Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli.

Journal

Cell Signal 18:441-8 (2006)
DOI:10.1016/j.cellsig.2005.05.013

Reference

Authors

Stronach BE, Perrimon N

Title

Stress signaling in Drosophila.

Journal

Oncogene 18:6172-82 (1999)
DOI:10.1038/sj.onc.1203125

Related
pathway

Apoptosis - fly

KO pathway

LinkDB

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