KEGG   PATHWAY: blat00260
Entry
blat00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia latens
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
blat00260  Glycine, serine and threonine metabolism
blat00260

Module
blat_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:blat00260]
blat_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:blat00260]
blat_M00555  Betaine biosynthesis, choline => betaine [PATH:blat00260]
blat_M00621  Glycine cleavage system [PATH:blat00260]
blat_M00919  Ectoine degradation, ectoine => aspartate [PATH:blat00260]
blat_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:blat00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia latens [GN:blat]
Gene
WK25_10020  aspartate kinase [KO:K00928] [EC:2.7.2.4]
WK25_22350  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
WK25_08975  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
WK25_21970  homoserine kinase [KO:K02204] [EC:2.7.1.39]
WK25_08970  threonine synthase [KO:K01733] [EC:4.2.3.1]
WK25_28895  threonine aldolase [KO:K01620] [EC:4.1.2.48]
WK25_20310  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
WK25_27625  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
WK25_03730  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
WK25_15875  hypothetical protein [KO:K00600] [EC:2.1.2.1]
WK25_14325  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
WK25_19195  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
WK25_08435  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
WK25_05235  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
WK25_09365  glycerate kinase [KO:K00865] [EC:2.7.1.165]
WK25_13785  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
WK25_03290  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
WK25_27335  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
WK25_15340  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
WK25_04920  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
WK25_08610  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
WK25_03725  NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
WK25_19520  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
WK25_19525  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
WK25_01990  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
WK25_01980  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
WK25_07455  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
WK25_10345  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
WK25_06230  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
WK25_01985  glycine cleavage system protein H [KO:K02437]
WK25_11025  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
WK25_27700  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
WK25_27695  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
WK25_20230  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
WK25_27590  (Fe-S)-binding protein [KO:K00479] [EC:1.14.13.251]
WK25_27585  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
WK25_27610  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
WK25_27605  (Fe-S)-binding protein [KO:K21834]
WK25_27600  electron transfer flavoprotein subunit alpha [KO:K25960]
WK25_27595  drug:proton antiporter [KO:K25961]
WK25_27840  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
WK25_27850  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
WK25_27835  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
WK25_27845  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
WK25_02000  serine dehydratase [KO:K01752] [EC:4.3.1.17]
WK25_27855  serine dehydratase [KO:K01752] [EC:4.3.1.17]
WK25_09455  pyridoxal-5'-phosphate-dependent protein subunit beta [KO:K01754] [EC:4.3.1.19]
WK25_18040  eutB; ectoine utilization protein EutB [KO:K01754] [EC:4.3.1.19]
WK25_13260  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
WK25_06280  serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
WK25_10385  aspartate racemase [KO:K25316] [EC:5.1.1.10]
WK25_22380  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
WK25_22370  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
WK25_18050  ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
WK25_18055  N-alpha-acetyl diaminobutyric acid deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
WK25_18070  hypothetical protein [KO:K15785] [EC:2.6.1.76]
WK25_18065  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
blat00010  Glycolysis / Gluconeogenesis
blat00020  Citrate cycle (TCA cycle)
blat00230  Purine metabolism
blat00250  Alanine, aspartate and glutamate metabolism
blat00270  Cysteine and methionine metabolism
blat00290  Valine, leucine and isoleucine biosynthesis
blat00300  Lysine biosynthesis
blat00330  Arginine and proline metabolism
blat00460  Cyanoamino acid metabolism
blat00470  D-Amino acid metabolism
blat00564  Glycerophospholipid metabolism
blat00600  Sphingolipid metabolism
blat00620  Pyruvate metabolism
blat00630  Glyoxylate and dicarboxylate metabolism
blat00640  Propanoate metabolism
blat00680  Methane metabolism
blat00860  Porphyrin metabolism
blat00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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