KEGG   PATHWAY: bman04141
Entry
bman04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Bombyx mandarina (wild silkworm)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
bman04141  Protein processing in endoplasmic reticulum
bman04141

Other DBs
GO: 0030433 0034976
Organism
Bombyx mandarina (wild silkworm) [GN:bman]
Gene
114239861  protein transport protein Sec61 subunit alpha [KO:K10956]
114250962  protein transport protein Sec61 subunit beta [KO:K09481]
114249994  protein transport protein Sec61 subunit gamma [KO:K07342]
114250577  translocation protein SEC63 homolog [KO:K09540]
114244049  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 isoform X1 [KO:K12666]
114244070  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
114243783  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
114248940  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
114243949  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X1 [KO:K07151] [EC:2.4.99.18]
114249944  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
114244079  tumor suppressor candidate 3 [KO:K19478]
114241213  oligosaccharyltransferase complex subunit ostc-A [KO:K26501]
114239967  transmembrane protein 258 [KO:K26502]
114243551  mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
114245750  ribosome-binding protein 1 isoform X1 [KO:K14000]
114246484  hypoxia up-regulated protein 1 [KO:K09486]
114242575  endoplasmic reticulum chaperone BiP isoform X1 [KO:K09490] [EC:3.6.4.10]
114250582  dnaJ homolog shv [KO:K09517]
114249013  uncharacterized protein F54F2.9 [KO:K09521]
114249206  dnaJ homolog subfamily C member 3 [KO:K09523]
114252079  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
114252080  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
114247057  endoplasmin isoform X1 [KO:K09487]
114241007  neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
114241361  glucosidase 2 subunit beta [KO:K08288]
114239701  calnexin [KO:K08054]
114242832  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
114249479  calreticulin [KO:K08057]
114239688  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
114239715  mannosyl-oligosaccharide alpha-1,2-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
114244560  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
114247337  vesicular integral-membrane protein VIP36 [KO:K10082]
114250247  protein ERGIC-53 [KO:K10080]
114249967  prolactin regulatory element-binding protein [KO:K14003]
114242154  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
114243886  protein SEC13 homolog [KO:K14004]
114245407  protein transport protein Sec31A [KO:K14005]
114243884  protein transport protein Sec23A isoform X1 [KO:K14006]
114240210  protein transport protein Sec24A [KO:K14007]
114251696  protein transport protein Sec24C isoform X1 [KO:K14007]
114241708  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
114246113  ER degradation-enhancing alpha-mannosidase-like protein 2 isoform X1 [KO:K10085]
114245139  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
114242191  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
114244057  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
114250395  protein windbeutel [KO:K09586]
114252982  thioredoxin domain-containing protein 5 homolog [KO:K13984] [EC:5.3.4.1]
114246226  ero1-like protein isoform X1 [KO:K10950] [EC:1.8.4.-]
114243109  endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
114242247  translocon-associated protein subunit alpha [KO:K13249]
114250676  translocon-associated protein subunit beta [KO:K13250]
114249902  translocon-associated protein subunit gamma [KO:K13251]
114243467  translocon-associated protein subunit delta [KO:K04571]
114242967  B-cell receptor-associated protein 31 [KO:K14009]
114240280  B-cell receptor-associated protein 31-like [KO:K14009]
114249140  translocating chain-associated membrane protein 1 [KO:K14010]
114250707  derlin-1 [KO:K11519]
114248179  derlin-2 [KO:K13989]
114252561  UBX domain-containing protein 4 isoform X1 [KO:K24348]
114243441  UBX domain-containing protein 1 [KO:K24348]
114243362  UBX domain-containing protein 6 [KO:K14011]
114243807  NSFL1 cofactor p47 [KO:K14012]
114239348  transitional endoplasmic reticulum ATPase TER94 [KO:K13525]
114248688  nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
114250370  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
114252937  heat shock 70 kDa protein cognate 2-like [KO:K03283]
114252521  heat shock protein 68-like isoform X1 [KO:K03283]
114253502  heat shock protein 68-like isoform X1 [KO:K03283]
114253503  heat shock protein 68-like [KO:K03283]
114245244  heat shock 70 kDa protein cognate 4 [KO:K03283]
114251668  heat shock protein 68-like [KO:K03283]
114243581  dnaJ homolog subfamily A member 1 [KO:K09502]
114247459  dnaJ homolog subfamily A member 2-like [KO:K09503]
114246010  dnaJ protein homolog 1 [KO:K09507]
114243846  dnaJ homolog subfamily B member 12 [KO:K09518]
114249352  dnaJ homolog subfamily C member 5 isoform X1 [KO:K09525]
114253500  heat shock protein 83 [KO:K04079]
114248504  97 kDa heat shock protein isoform X1 [KO:K09485]
114239415  BAG family molecular chaperone regulator 2 [KO:K09556]
114242222  hsp70-binding protein 1 [KO:K09562]
114253505  protein lethal(2)essential for life-like [KO:K09542]
114253610  protein lethal(2)essential for life-like [KO:K09542]
114247472  alpha-crystallin B chain-like [KO:K09542]
114250683  protein lethal(2)essential for life-like [KO:K09542]
114250684  alpha-crystallin A chain-like [KO:K09542]
114251734  heat shock protein Hsp-12.2-like [KO:K09542]
114239574  protein lethal(2)essential for life-like [KO:K09542]
114239594  alpha-crystallin B chain-like [KO:K09542]
114239597  protein lethal(2)essential for life-like [KO:K09542]
114239599  protein lethal(2)essential for life-like [KO:K09542]
114239605  protein lethal(2)essential for life-like [KO:K09542]
114245251  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
114245231  phospholipase A-2-activating protein [KO:K14018]
114251568  UV excision repair protein RAD23 homolog A [KO:K10839]
114241029  ubiquilin-1 isoform X1 [KO:K04523]
114239442  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
114242299  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
114249574  activating transcription factor of chaperone [KO:K04374]
114245507  cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09054]
114250763  wolframin isoform X1 [KO:K14020]
114246930  membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
114246975  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
114246266  X-box-binding protein 1 [KO:K09027]
114253329  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
114248799  mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]
114242559  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
114250596  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
114243281  E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
114243961  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
114251107  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
114247707  ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
114240257  E3 ubiquitin-protein ligase synoviolin A [KO:K10601] [EC:2.3.2.27]
114246103  E3 ubiquitin-protein ligase RNF185-like isoform X1 [KO:K10666] [EC:2.3.2.27]
114244161  selenoprotein S-like [KO:K14025]
114251205  protein sel-1 homolog 1 isoform X1 [KO:K14026]
114243734  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
114240644  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
114248509  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
114241891  cullin-1 [KO:K03347]
114248511  S-phase kinase-associated protein 1 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
bman00510  N-Glycan biosynthesis
bman03050  Proteasome
bman03060  Protein export
KO pathway
ko04141   
LinkDB

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