KEGG   PATHWAY: bom00982
Entry
bom00982                    Pathway                                
Name
Drug metabolism - cytochrome P450 - Bos mutus (wild yak)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
bom00982  Drug metabolism - cytochrome P450
bom00982

Organism
Bos mutus (wild yak) [GN:bom]
Gene
102275664  FMO5; flavin containing monooxygenase 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
102276494  FMO1; flavin containing monooxygenase 1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
102276938  FMO4; flavin containing monooxygenase 4 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
102276201  FMO2; flavin containing monooxygenase 2 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
102275445  FMO3; flavin containing monooxygenase 3 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
102275918  putative dimethylaniline monooxygenase [N-oxide-forming] 6 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
102264945  dimethylaniline monooxygenase [N-oxide-forming] 5-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
102287938  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
102268301  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
102282708  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
102283655  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
102283179  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
102281969  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
102282430  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
102281683  GSTM3; glutathione S-transferase mu 3 [KO:K00799] [EC:2.5.1.18]
102264374  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
102276470  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
102276661  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
102278818  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
102288314  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
102264698  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
102288026  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
102280813  GSTA4; glutathione S-transferase alpha 4 [KO:K00799] [EC:2.5.1.18]
102271019  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
102274807  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
102288177  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
102276933  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
102272205  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
102271929  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
102271847  GSTK1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
102269024  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
102269619  ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
102284797  alcohol dehydrogenase E chain [KO:K13951] [EC:1.1.1.1]
102283964  ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
102283691  ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
102284246  ADH6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
102267436  aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
102269123  ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
102273352  aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
102278499  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
102278212  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
102272565  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
102281032  aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
102283927  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
102270291  UDP-glucuronosyltransferase 1-3 [KO:K00699] [EC:2.4.1.17]
102264665  UGT1A1; UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]
102282379  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
102281360  UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]
102283308  UGT2B4; UDP-glucuronosyltransferase 2B4 [KO:K00699] [EC:2.4.1.17]
102282831  UDP-glucuronosyltransferase 2B4 [KO:K00699] [EC:2.4.1.17]
102283981  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
102284258  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
102276699  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
102276238  UGT2B17; UDP-glucuronosyltransferase 2B4 [KO:K00699] [EC:2.4.1.17]
102269158  UDP-glucuronosyltransferase 1-3 [KO:K00699] [EC:2.4.1.17]
102270864  UGT1A10; UDP-glucuronosyltransferase 1-9 [KO:K00699] [EC:2.4.1.17]
102280158  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
102281471  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
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