KEGG   PATHWAY: bpyr00260
Entry
bpyr00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia pyrrocinia
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bpyr00260  Glycine, serine and threonine metabolism
bpyr00260

Module
bpyr_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bpyr00260]
bpyr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bpyr00260]
bpyr_M00555  Betaine biosynthesis, choline => betaine [PATH:bpyr00260]
bpyr_M00621  Glycine cleavage system [PATH:bpyr00260]
bpyr_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bpyr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia pyrrocinia [GN:bpyr]
Gene
ABD05_00295  aspartate kinase [KO:K00928] [EC:2.7.2.4]
ABD05_16860  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
ABD05_15430  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
ABD05_17310  serine kinase [KO:K02204] [EC:2.7.1.39]
ABD05_15425  threonine synthase [KO:K01733] [EC:4.2.3.1]
ABD05_22350  threonine aldolase [KO:K01620] [EC:4.1.2.48]
ABD05_09630  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ABD05_23975  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ABD05_14380  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
ABD05_04830  glyoxylate reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ABD05_33295  2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ABD05_14780  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
ABD05_11135  2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
ABD05_15830  glycerate kinase [KO:K00865] [EC:2.7.1.165]
ABD05_04325  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
ABD05_09000  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
ABD05_05720  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
ABD05_10820  MFS transporter [KO:K00831] [EC:2.6.1.52]
ABD05_15070  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
ABD05_09625  malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
ABD05_21385  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
ABD05_21380  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
ABD05_20645  amine oxidase [KO:K00274] [EC:1.4.3.4]
ABD05_20695  amine oxidase [KO:K00274] [EC:1.4.3.4]
ABD05_06745  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
ABD05_06755  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
ABD05_13345  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ABD05_00590  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ABD05_11955  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ABD05_06750  glycine cleavage system H protein [KO:K02437]
ABD05_01335  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
ABD05_23900  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
ABD05_19610  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
ABD05_23905  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
ABD05_24010  (Fe-S)-binding protein [KO:K00479] [EC:1.14.13.251]
ABD05_24015  ferredoxin oxidoreductase [KO:K21832] [EC:1.14.13.251]
ABD05_23990  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
ABD05_23995  (Fe-S)-binding protein [KO:K21834]
ABD05_24000  electron transfer flavoprotein subunit alpha [KO:K25960]
ABD05_24005  drug:proton antiporter [KO:K25961]
ABD05_23710  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
ABD05_23700  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
ABD05_23715  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
ABD05_23705  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
ABD05_28965  SAM-dependent methlyltransferase [KO:K18897] [EC:2.1.1.157]
ABD05_30865  cysteine synthase [KO:K01697] [EC:4.2.1.22]
ABD05_06735  serine dehydratase [KO:K01752] [EC:4.3.1.17]
ABD05_23695  serine dehydratase [KO:K01752] [EC:4.3.1.17]
ABD05_15940  pyridoxal-5'-phosphate-dependent protein subunit beta [KO:K01754] [EC:4.3.1.19]
ABD05_03700  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
ABD05_12020  serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
ABD05_03740  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
ABD05_27525  serine dehydratase [KO:K01753] [EC:4.3.1.18]
ABD05_00630  aspartate racemase [KO:K25316] [EC:5.1.1.10]
ABD05_16825  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
ABD05_16835  tryptophan synthase subunit alpha [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bpyr00010  Glycolysis / Gluconeogenesis
bpyr00020  Citrate cycle (TCA cycle)
bpyr00230  Purine metabolism
bpyr00250  Alanine, aspartate and glutamate metabolism
bpyr00270  Cysteine and methionine metabolism
bpyr00290  Valine, leucine and isoleucine biosynthesis
bpyr00300  Lysine biosynthesis
bpyr00330  Arginine and proline metabolism
bpyr00460  Cyanoamino acid metabolism
bpyr00470  D-Amino acid metabolism
bpyr00564  Glycerophospholipid metabolism
bpyr00600  Sphingolipid metabolism
bpyr00620  Pyruvate metabolism
bpyr00630  Glyoxylate and dicarboxylate metabolism
bpyr00640  Propanoate metabolism
bpyr00680  Methane metabolism
bpyr00860  Porphyrin metabolism
bpyr00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system