KEGG   PATHWAY: brp00053
Entry
brp00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Brassica rapa (field mustard)
Class
Metabolism; Carbohydrate metabolism
Pathway map
brp00053  Ascorbate and aldarate metabolism
brp00053

Module
brp_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:brp00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Brassica rapa (field mustard) [GN:brp]
Gene
103840623  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
103846408  UDP-glucose 6-dehydrogenase 3 [KO:K00012] [EC:1.1.1.22]
103863829  UDP-glucose 6-dehydrogenase 4 [KO:K00012] [EC:1.1.1.22]
103850986  UDP-glucose 6-dehydrogenase 3 [KO:K00012] [EC:1.1.1.22]
103850139  UDP-glucose 6-dehydrogenase 4 [KO:K00012] [EC:1.1.1.22]
103856139  UDP-glucose 6-dehydrogenase 3 [KO:K00012] [EC:1.1.1.22]
108872254  LOW QUALITY PROTEIN: UDP-glucose 6-dehydrogenase 2 [KO:K00012] [EC:1.1.1.22]
103842186  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
103846481  LOW QUALITY PROTEIN: probable glucuronokinase 2 [KO:K16190] [EC:2.7.1.43]
103858900  glucuronokinase 1 [KO:K16190] [EC:2.7.1.43]
103849851  inositol oxygenase 4 [KO:K00469] [EC:1.13.99.1]
103828278  inositol oxygenase 2 [KO:K00469] [EC:1.13.99.1]
103837984  inositol oxygenase 2 [KO:K00469] [EC:1.13.99.1]
103872250  inositol oxygenase 1 isoform X1 [KO:K00469] [EC:1.13.99.1]
103851813  inositol oxygenase 5 [KO:K00469] [EC:1.13.99.1]
103867160  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
103857735  NADPH-dependent aldo-keto reductase, chloroplastic isoform X1 [KO:K00002] [EC:1.1.1.2]
103855408  aldose reductase isoform X2 [KO:K00002] [EC:1.1.1.2]
103867161  NADPH-dependent aldo-keto reductase, chloroplastic isoform X2 [KO:K00002] [EC:1.1.1.2]
103850775  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
103866437  L-gulonolactone oxidase 2 [KO:K00103] [EC:1.1.3.8]
103845085  probable L-gulonolactone oxidase 4 [KO:K00103] [EC:1.1.3.8]
103866439  L-gulonolactone oxidase 5 [KO:K00103] [EC:1.1.3.8]
103866436  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
103851822  probable L-gulonolactone oxidase 4 isoform X1 [KO:K00103] [EC:1.1.3.8]
103874594  GME; GDP-mannose 3,5-epimerase [KO:K10046] [EC:5.1.3.18 5.1.3.-]
103854620  GDP-mannose 3,5-epimerase [KO:K10046] [EC:5.1.3.18 5.1.3.-]
103866673  VTC2; GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
103834830  GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
103851903  GDP-L-galactose phosphorylase 2 [KO:K14190] [EC:2.7.7.69]
103861660  LOW QUALITY PROTEIN: GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
103870884  inositol-phosphate phosphatase isoform X2 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
103835143  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
103834464  LOW QUALITY PROTEIN: L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
103862253  GDH; L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
103873188  GLDH; L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
103852660  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
103832079  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
103839899  UDP-glucuronate 4-epimerase 5 [KO:K08679] [EC:5.1.3.6]
103828701  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
103836945  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
103860010  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
103853482  UDP-glucuronate 4-epimerase 5 [KO:K08679] [EC:5.1.3.6]
103861964  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
103858172  UDP-glucuronate 4-epimerase 4 [KO:K08679] [EC:5.1.3.6]
103854214  monodehydroascorbate reductase 4, peroxisomal-like [KO:K08232] [EC:1.6.5.4]
103841218  monodehydroascorbate reductase 1, peroxisomal [KO:K08232] [EC:1.6.5.4]
103875190  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
103838242  monodehydroascorbate reductase, chloroplastic/mitochondrial [KO:K08232] [EC:1.6.5.4]
103855533  monodehydroascorbate reductase 2 [KO:K08232] [EC:1.6.5.4]
103859275  monodehydroascorbate reductase 2 [KO:K08232] [EC:1.6.5.4]
103871729  L-ascorbate peroxidase 5, peroxisomal isoform X1 [KO:K00434] [EC:1.11.1.11]
103848043  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
103836413  L-ascorbate peroxidase 1, cytosolic-like [KO:K00434] [EC:1.11.1.11]
103838791  L-ascorbate peroxidase S, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
103832195  L-ascorbate peroxidase T, chloroplastic [KO:K00434] [EC:1.11.1.11]
103871533  L-ascorbate peroxidase 1, cytosolic isoform X1 [KO:K00434] [EC:1.11.1.11]
103843426  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
103860476  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
103862119  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
103862385  L-ascorbate peroxidase 3 isoform X2 [KO:K00434] [EC:1.11.1.11]
103835841  glutathione S-transferase DHAR1, mitochondrial [KO:K21888] [EC:1.8.5.1 2.5.1.18]
103846305  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
103851061  glutathione S-transferase DHAR3, chloroplastic isoform X1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
103852942  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
103872760  glutathione S-transferase DHAR1, mitochondrial [KO:K21888] [EC:1.8.5.1 2.5.1.18]
103845610  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
103851396  L-ascorbate oxidase isoform X1 [KO:K00423] [EC:1.10.3.3]
103849284  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
103845074  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
103845611  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
103845612  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
103871036  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
103849762  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
103849761  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
103832576  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
103859514  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
103859515  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
103870173  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
103832574  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
103870175  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
103868729  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
103840237  aldehyde dehydrogenase family 3 member I1, chloroplastic [KO:K00128] [EC:1.2.1.3]
103869258  aldehyde dehydrogenase family 3 member F1 isoform X1 [KO:K00128] [EC:1.2.1.3]
103833133  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
103835648  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
103834979  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
103873180  aldehyde dehydrogenase family 2 member B4, mitochondrial [KO:K00128] [EC:1.2.1.3]
103873557  aldehyde dehydrogenase family 2 member B4, mitochondrial isoform X3 [KO:K00128] [EC:1.2.1.3]
103840735  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
103862462  aldehyde dehydrogenase family 3 member F1 isoform X1 [KO:K00128] [EC:1.2.1.3]
103832634  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
brp00020  Citrate cycle (TCA cycle)
brp00040  Pentose and glucuronate interconversions
brp00051  Fructose and mannose metabolism
brp00520  Amino sugar and nucleotide sugar metabolism
brp00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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