KEGG   PATHWAY: btab00983
Entry
btab00983                   Pathway                                
Name
Drug metabolism - other enzymes - Bemisia tabaci (sweet potato whitefly)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
btab00983  Drug metabolism - other enzymes
btab00983

Organism
Bemisia tabaci (sweet potato whitefly) [GN:btab]
Gene
109036136  inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
109036232  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
109043878  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109038855  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109038856  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109038857  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
109030032  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
109030100  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
109029739  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109030357  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
109030368  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109030369  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109030370  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109030371  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109030372  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
109030373  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
109030374  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
109030375  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109030336  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
109030420  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
109029876  UDP-glucuronosyltransferase 2B18-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109034840  UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
109034860  UDP-glucuronosyltransferase 2B14-like [KO:K00699] [EC:2.4.1.17]
109036871  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
109039028  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
109039029  UDP-glucuronosyltransferase 2B9-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109042889  UDP-glucuronosyltransferase 2B18-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109040838  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109040852  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109030843  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109031897  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109031899  UDP-glucuronosyltransferase 2B2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109030936  UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
109035046  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
109037087  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
109037135  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
109039954  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
109033002  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109036144  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
109037151  UDP-glucuronosyltransferase 2B13-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109033094  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109036246  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
109036250  UDP-glucuronosyltransferase 2B13-like [KO:K00699] [EC:2.4.1.17]
109036264  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
109037316  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109040109  UDP-glucuronosyltransferase 2B20-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109037352  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
109042315  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109033275  UDP-glucuronosyltransferase 2B9-like [KO:K00699] [EC:2.4.1.17]
109039208  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
109031307  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K00699] [EC:2.4.1.17]
109035425  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
109040322  UDP-glucuronosyltransferase 2B2-like [KO:K00699] [EC:2.4.1.17]
109041340  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
109032402  UDP-glucuronosyltransferase 2B2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109032412  UDP-glucuronosyltransferase 2B11-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109039327  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
109043524  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109031455  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
109033483  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109034533  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109034534  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109034535  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
109034536  UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
109037643  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
109039385  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109044573  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
109044583  UDP-glucuronosyltransferase 2B10-like [KO:K00699] [EC:2.4.1.17]
109044588  UDP-glucuronosyltransferase 2B14-like [KO:K00699] [EC:2.4.1.17]
109042596  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
109044625  UDP-glucuronosyltransferase 2B9-like [KO:K00699] [EC:2.4.1.17]
109032577  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
109035695  UDP-glucuronosyltransferase 2B14-like [KO:K00699] [EC:2.4.1.17]
109040684  UDP-glucuronosyltransferase 1-1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
109040694  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
109043808  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
109030411  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
109043073  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
109030996  thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
109030148  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
109034435  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
109043677  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
109033958  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
109037857  probable uridine-cytidine kinase isoform X1 [KO:K00876] [EC:2.7.1.48]
109040308  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
109035918  thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
109036513  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
109041201  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
109036078  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
109040977  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
109042417  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
109030906  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
109033198  nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
109031833  deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
109040990  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
109043132  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
109039556  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
109041942  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109041950  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109041958  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
109040635  uncharacterized protein LOC109040635 [KO:K00799] [EC:2.5.1.18]
109040643  uncharacterized protein LOC109040643 [KO:K00799] [EC:2.5.1.18]
109041830  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
109032656  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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