KEGG   PATHWAY: btrm02024
Entry
btrm02024                   Pathway                                
Name
Quorum sensing - Bordetella trematum
Description
Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
Class
Cellular Processes; Cellular community - prokaryotes
Pathway map
btrm02024  Quorum sensing
btrm02024

Other DBs
GO: 0009372
Organism
Bordetella trematum [GN:btrm]
Gene
SAMEA390648704024  hfq; RNA-binding protein Hfq [KO:K03666]
SAMEA390648700951  trpE; anthranilate synthase component I [KO:K01657] [EC:4.1.3.27]
SAMEA390648700952  pabA; anthranilate synthase component II [KO:K01658] [EC:4.1.3.27]
SAMEA390648703015  aroG1; phospho-2-dehydro-3-deoxyheptonate aldolase [KO:K01626] [EC:2.5.1.54]
SAMEA390648703713  aroG2; phospho-2-dehydro-3-deoxyheptonate aldolase [KO:K01626] [EC:2.5.1.54]
SAMEA390648700109  qseC_1; sensor histidine kinase qsec [KO:K07645] [EC:2.7.13.3]
SAMEA390648703129  qseC_4; two-component system histidine kinase [KO:K07645] [EC:2.7.13.3]
SAMEA390648704218  qseC_7; sensor histidine kinase qsec [KO:K07645] [EC:2.7.13.3]
SAMEA390648704216  qseB3_4; two component response regulator [KO:K07666]
SAMEA390648700110  qseB3_1; two component response regulator [KO:K07666]
SAMEA390648703130  qseB3_3; two component response regulator [KO:K07666]
SAMEA390648703479  flhD; flagellar transcriptional activator FlbB [KO:K02403]
SAMEA390648703478  flaI; transcriptional activator FlhC [KO:K02402]
SAMEA390648701731  kdpE; two component response regulator [KO:K07667]
SAMEA390648702011  gadA2; glutamate decarboxylase alpha/beta [KO:K01580] [EC:4.1.1.15]
SAMEA390648702845  Conjugal transfer protein TrbJ [KO:K20266]
SAMEA390648702847  conjugal transfer protein TrbL [KO:K07344]
SAMEA390648701610  potF_1; extracellular substrate-binding protein [KO:K02055]
SAMEA390648701125  ABC transporter substrate-binding protein [KO:K02055]
SAMEA390648701612  ydcV_1; ABC transporter permease [KO:K02053]
SAMEA390648701126  modB_1; binding-protein-dependent transport system%2C permease [KO:K02053]
SAMEA390648701127  potB; ABC transporter permease [KO:K02053]
SAMEA390648701611  potH_1; ABC transporter permease [KO:K02054]
SAMEA390648701609  potA_2; ABC transporter ATP-binding protein [KO:K02052]
SAMEA390648701128  potA_1; ABC transporter ATP-binding protein [KO:K02052]
SAMEA390648702585  ABC transportersubstrate-binding component [KO:K01999]
SAMEA390648702739  ABC transporter substrate binding protein [KO:K01999]
SAMEA390648703200  livJ2; leu/ile/val-binding protein [KO:K01999]
SAMEA390648703207  livJ1; high-affinity branched-chain amino acid ABC transporter leu/ile/val-binding protein [KO:K01999]
SAMEA390648701010  amiC_2; substrate-binding periplasmic transport protein [KO:K01999]
SAMEA390648701267  braC_2; branched-chain amino acid-binding protein [KO:K01999]
SAMEA390648702023  livJ_1; binding-protein-dependent transport protein [KO:K01999]
SAMEA390648702528  braC_5; ABC transporter substrate-binding protein [KO:K01999]
SAMEA390648702535  ABC transporter substrate-binding protein [KO:K01999]
SAMEA390648703182  livJ_2; ABC transporter substrate-binding protein [KO:K01999]
SAMEA390648702404  ABC transporter substrate-binding protein [KO:K01999]
SAMEA390648701432  branched-chain amino acid ABC transporter periplasmic amino acid-binding protein [KO:K01999]
SAMEA390648700763  braC_1; ABC transporter substrate-binding protein [KO:K01999]
SAMEA390648701680  braC_4; amino acid ABC transporter substrate-binding protein [KO:K01999]
SAMEA390648701689  ABC transporter substrate-binding protein [KO:K01999]
SAMEA390648704193  branched-chain amino acid-binding protein [KO:K01999]
SAMEA390648701505  braC_3; ABC transporter substrate-binding protein [KO:K01999]
SAMEA390648703208  livH_13; high-affinity branched-chain amino acid ABC transporter permease [KO:K01997]
SAMEA390648701264  livH_3; ABC transporter permease [KO:K01997]
SAMEA390648702022  livH_8; ABC transporter inner membrane protein [KO:K01997]
SAMEA390648702529  livH_9; branched-chain amino acid ABC transporter permease [KO:K01997]
SAMEA390648702534  livH_10; ABC transporter permease [KO:K01997]
SAMEA390648703183  livH_11; ABC transporter permease [KO:K01997]
SAMEA390648701434  livH_4; branched-chain amino acid ABC transporter permease [KO:K01997]
SAMEA390648700762  livH_1; ABC transporter permease [KO:K01997]
SAMEA390648701681  livH_7; branched-chain amino acid ABC transporter permease [KO:K01997]
SAMEA390648701504  livH_6; ABC transporter permease [KO:K01997]
SAMEA390648702530  lptB_9; branched-chain amino acid ABC transporter ATP-binding/permease [KO:K01995 K01998]
SAMEA390648702021  high-affinity branched-chain amino acid transport system permease [KO:K01998]
SAMEA390648702533  ABC transporter permease [KO:K01998]
SAMEA390648703184  livH_12; ABC transporter permease [KO:K01998]
SAMEA390648703209  livM; high-affinity branched-chain amino acid transport system permease [KO:K01998]
SAMEA390648701263  ABC transporter permease [KO:K01998]
SAMEA390648701503  livH_5; ABC transporter permease [KO:K01998]
SAMEA390648701682  branched-chain amino acid ABC transporter permease [KO:K01998]
SAMEA390648701433  branched-chain amino acid ABC transporter permease [KO:K01998]
SAMEA390648700761  ABC transporter permease [KO:K01998]
SAMEA390648703210  livG; leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01995]
SAMEA390648701266  lptB_4; branched-chain amino acid ABC transporter ATP-binding protein [KO:K01995]
SAMEA390648701502  lptB_6; ABC transporter ATP-binding protein [KO:K01995]
SAMEA390648702020  lptB_8; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01995]
SAMEA390648702537  drrA; ABC transporter ATP-binding protein [KO:K01995]
SAMEA390648703185  lptB_10; ABC transporter ATP-binding protein [KO:K01995]
SAMEA390648701435  lptB_5; high-affinity branched-chain amino acid transporter%2C ATP-binding protein [KO:K01995]
SAMEA390648700760  lptB_1; ABC transporter ATP-binding protein [KO:K01995]
SAMEA390648701683  lptB_7; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01995]
SAMEA390648702019  livF_7; ABC transporter ATP-binding protein [KO:K01996]
SAMEA390648702531  livF_8; branched-chain amino acid transport system protein [KO:K01996]
SAMEA390648702536  livF_9; ABC transporter ATP-binding protein [KO:K01996]
SAMEA390648703186  livF_10; ABC transporter ATP-binding protein [KO:K01996]
SAMEA390648703211  livF_11; high-affinity branched-chain amino acid ABC transporter ATP-binding protein [KO:K01996]
SAMEA390648701265  livF_3; branched-chain amino acid ABC transporter ATP-binding protein [KO:K01996]
SAMEA390648701501  livF_5; ABC transporter ATP-binding protein [KO:K01996]
SAMEA390648701684  livF_6; ABC transporter ATP-binding protein [KO:K01996]
SAMEA390648701431  livF_4; high-affinity branched-chain amino acid ABC transporter ATP-binding protein [KO:K01996]
SAMEA390648700759  livF_1; ABC transporter ATP-binding protein [KO:K01996]
SAMEA390648702990  adhesin [KO:K20276]
SAMEA390648700527  fadD_2; long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
SAMEA390648701436  AMP-binding enzyme [KO:K01897] [EC:6.2.1.3]
SAMEA390648704147  fadD_9; substrate-CoA ligase [KO:K01897] [EC:6.2.1.3]
SAMEA390648700442  fcbA2; AMP-binding protein [KO:K01897] [EC:6.2.1.3]
SAMEA390648702403  cyclic nucleotide-binding regulatory protein [KO:K10914]
SAMEA390648701437  vfr; cyclic nucleotide-binding regulatory protein [KO:K10914]
SAMEA390648701387  zur; cation uptake regulatory protein [KO:K09823]
SAMEA390648700691  ribD; riboflavin biosynthesis protein [includes diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino)uracil reductase [KO:K11752] [EC:3.5.4.26 1.1.1.193]
SAMEA390648701208  bepD; HlyD family secretion protein [KO:K18306]
SAMEA390648701207  bepE_3; multidrug efflux system integral membrane protein [KO:K18307]
SAMEA390648703495  oprM_4; multidrug efflux system outer membrane protein [KO:K18139]
SAMEA390648700488  cusC1; outer membrane efflux protein [KO:K18139]
SAMEA390648704157  oprM_6; multidrug efflux system outer membrane protein [KO:K18139]
SAMEA390648703357  oprM_3; outer membrane efflux protein [KO:K18139]
SAMEA390648700918  gsiB_1; ABC transporter substrate-binding protein [KO:K02035]
SAMEA390648701747  appA_2; extracellular solute-binding protein [KO:K02035]
SAMEA390648702466  gsiB_5; ABC transporter substrate binding protein [KO:K02035]
SAMEA390648702664  dppA_2; ABC transporter substrate-binding protein [KO:K02035]
SAMEA390648703051  hbpA_3; solute-binding transport protein (periplasmic) [KO:K02035]
SAMEA390648703052  hbpA_4; solute-binding transport protein (periplasmic) [KO:K02035]
SAMEA390648703252  dppA_3; extracellular solute-binding protein [KO:K02035]
SAMEA390648703506  dppA_4; ABC transporter substrate binding protein [KO:K02035]
SAMEA390648701744  appA_1; extracellular substrate-binding protein%2Cfamily 5 [KO:K02035]
SAMEA390648702427  gsiB_4; extracellular substrate-binding protein [KO:K02035]
SAMEA390648702034  hbpA_2; ABC transporter substrate-binding protein [KO:K02035]
SAMEA390648702051  ygiS; ABC transporter substrate-binding protein [KO:K02035]
SAMEA390648702093  gsiB_3; extracellular solute-binding protein [KO:K02035]
SAMEA390648701108  gsiB_2; extracellular solute-binding protein [KO:K02035]
SAMEA390648700023  hbpA_1; ABC transporter substrate-binding protein [KO:K02035]
SAMEA390648702762  gsiB_7; binding-protein-dependent transport periplasmic protein [KO:K02035]
SAMEA390648700022  gsiC_1; oligopeptide transport system permease [KO:K02033]
SAMEA390648700920  dppB_1; ABC transporter permease [KO:K02033]
SAMEA390648701748  gsiC_2; ABC transporter permease [KO:K02033]
SAMEA390648702470  dppB_3; transport system permease [KO:K02033]
SAMEA390648702663  gsiC_7; binding-protein-dependent permease [KO:K02033]
SAMEA390648703050  dppB_4; ABC transporter permease [KO:K02033]
SAMEA390648703253  gsiC_9; ABC transporter permease [KO:K02033]
SAMEA390648703505  dppB_5; ABC transporter inner membrane protein [KO:K02033]
SAMEA390648702424  gsiC_5; binding-protein-dependent transport systems inner membrane protein [KO:K02033]
SAMEA390648702033  gsiC_3; ABC transporter protein inner membrane protein [KO:K02033]
SAMEA390648702052  gsiC_4; ABC transporter permease [KO:K02033]
SAMEA390648701109  dppB_2; transport system permease [KO:K02033]
SAMEA390648702760  gsiC_8; ABC transporter permease [KO:K02033]
SAMEA390648700021  oppC_1; ABC transporter permease [KO:K02034]
SAMEA390648700921  ddpC_1; ABC transporter permease [KO:K02034]
SAMEA390648701749  dppC_2; ABC transporter permease [KO:K02034]
SAMEA390648702469  dppC_3; ABC transporter permease [KO:K02034]
SAMEA390648702662  dppC_4; ABC transporter permease [KO:K02034]
SAMEA390648703254  oppC_2; ABC transporter permease [KO:K02034]
SAMEA390648703504  gsiD_5; ABC transporter permease [KO:K02034]
SAMEA390648702425  gsiD_2; binding-protein-dependent transport systems inner membrane protein [KO:K02034]
SAMEA390648702032  ddpC_2; ABC transporter protein inner membrane protein [KO:K02034]
SAMEA390648702053  gsiD_1; ABC transporter permease [KO:K02034]
SAMEA390648701110  dppC_1; ABC transporter permease [KO:K02034]
SAMEA390648702761  gsiD_4; ABC transporter permease [KO:K02034]
SAMEA390648702426  gsiA_8; ABC transporter ATP-binding protein [KO:K02031 K02032]
SAMEA390648700020  gsiA_1; ABC transporter ATP-binding protein [KO:K02031 K02032]
SAMEA390648700922  gsiA_2; ABC transporter ATP-binding protein [KO:K02031]
SAMEA390648701750  gsiA_5; ABC transporter ATP-binding protein [KO:K02031 K02032]
SAMEA390648702031  gsiA_6; ABC transporter ATP-binding protein [KO:K02031 K02032]
SAMEA390648702468  gsiA_10; ABC transporter ATP-binding protein [KO:K02031]
SAMEA390648703048  gsiA_16; ABC transporter ATP-binding protein [KO:K02031 K02032]
SAMEA390648703255  gsiA_17; ABC transporter ATP-binding protein [KO:K02031 K02032]
SAMEA390648703503  gsiA_18; ABC transporter ATP-binding protein [KO:K02031 K02032]
SAMEA390648702764  gsiA_14; oligopeptide ABC transporter ATP-binding protein [KO:K02031]
SAMEA390648702054  gsiA_7; oligopeptide ABC transporter ATP-binding protein [KO:K02031]
SAMEA390648701111  gsiA_4; ABC transporter ATP-binding protein [KO:K02031 K02032]
SAMEA390648702661  gsiA_13; ABC transporter ATP-binding protein [KO:K02031]
SAMEA390648702660  gsiA_12; ABC transporter ATP-binding protein [KO:K02032]
SAMEA390648702765  gsiA_15; ABC transporter ATP-binding protein [KO:K02032]
SAMEA390648702055  appF; oligopeptide ABC transporter ATP-binding protein [KO:K02032]
SAMEA390648701199  oxaA; putative inner membrane protein translocase component YidC [KO:K03217]
SAMEA390648701234  secE; preprotein translocase subunit SecE [KO:K03073]
SAMEA390648700193  secG; preprotein translocase subunit SecG [KO:K03075]
SAMEA390648701282  secY; preprotein translocase subunit SecY [KO:K03076]
SAMEA390648702149  yajC; preprotein translocase subunit YajC [KO:K03210]
SAMEA390648702993  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
SAMEA390648700539  secA2; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
SAMEA390648701855  ftsY; cell division protein [KO:K03110]
SAMEA390648701477  secB; protein-export protein [KO:K03071]
SAMEA390648701647  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00059  Sulfate
C00232  Succinate semialdehyde
C00334  4-Aminobutanoate
C00547  L-Noradrenaline
C00788  L-Adrenaline
C01019  L-Fucose
C11837  N-Butyryl-L-homoserine lactone
C11841  N-(3-Oxooctanoyl)homoserine lactone
C11844  N-Heptanoylhomoserine lactone
C11845  N-(3-Hydroxy-7-cis-tetradecenoyl)homoserine lactone
C11848  2-Heptyl-3-hydroxy-quinolone
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C18049  N-Acyl-L-homoserine lactone
C18206  cis-11-Methyl-2-dodecenoic acid
C20643  2-Heptyl-4(1H)-quinolone
C20677  N-(4-Coumaroyl)-L-homoserine lactone
C20959  (4S)-4-Hydroxy-5-phosphooxypentane-2,3-dione
C21195  N-(3-Hydroxybutanoyl)-L-homoserine lactone
C21197  N-Hexanoyl-L-homoserine lactone
C21198  N-(3-Oxohexanoyl)-L-homoserine lactone
C21199  N-Octanoyl-L-homoserine lactone
C21200  N-3-Hydroxyoctanoyl-L-homoserine lactone
C21201  N-3-Oxo-dodecanoyl-L-homoserine lactone
C21202  cis-2-Dodecenoic acid
C21220  AIP-1
C21221  CSP
C21222  CSP
C21223  Blp
C21224  SHP2
C21225  SHP3
C21226  cCF10
C21227  iCF10
C21228  cAD1
C21229  iAD1
C21230  ComX pheromone
C21231  PhrA pentapeptide
C21232  PhrC pentapeptide
C21233  PhrE pentapeptide
C21234  PhrF pentapeptide
C21235  PhrG pentapeptide
C21236  PhrH pentapeptide
C21237  PhrK pentapeptide
C21238  NprX peptide
C21239  PapR peptide
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21244  AgrD peptide
C21245  AgrD1 peptide
C21246  GBAP
C21382  R-THMF
Reference
PMID:22712853
  Authors
Pereira CS, Thompson JA, Xavier KB
  Title
AI-2-mediated signalling in bacteria.
  Journal
FEMS Microbiol Rev 37:156-81 (2013)
DOI:10.1111/j.1574-6976.2012.00345.x
Reference
PMID:23965960
  Authors
Verma SC, Miyashiro T
  Title
Quorum sensing in the squid-Vibrio symbiosis.
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Int J Mol Sci 14:16386-401 (2013)
DOI:10.3390/ijms140816386
Reference
PMID:24348467
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Norsworthy AN, Visick KL
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Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
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Front Microbiol 4:356 (2013)
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Reference
PMID:24065108
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Papaioannou E, Utari PD, Quax WJ
  Title
Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.
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Int J Mol Sci 14:19309-40 (2013)
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Reference
PMID:20738404
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Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Camara M
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FEMS Microbiol Rev 35:247-74 (2011)
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PMID:25866808
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The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
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Biomed Res Int 2015:759348 (2015)
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Reference
PMID:11544214
  Authors
Whiteley M, Greenberg EP
  Title
Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes.
  Journal
J Bacteriol 183:5529-34 (2001)
DOI:10.1128/JB.183.19.5529-5534.2001
Reference
PMID:11497469
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Chin-A-Woeng TF, van den Broek D, de Voer G, van der Drift KM, Tuinman S, Thomas-Oates JE, Lugtenberg BJ, Bloemberg GV
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Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium.
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Mol Plant Microbe Interact 14:969-79 (2001)
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Reference
PMID:19696934
  Authors
Hughes DT, Clarke MB, Yamamoto K, Rasko DA, Sperandio V
  Title
The QseC adrenergic signaling cascade in Enterohemorrhagic E. coli (EHEC).
  Journal
PLoS Pathog 5:e1000553 (2009)
DOI:10.1371/journal.ppat.1000553
Reference
PMID:22144490
  Authors
Njoroge J, Sperandio V
  Title
Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE.
  Journal
Infect Immun 80:688-703 (2012)
DOI:10.1128/IAI.05921-11
Reference
PMID:23160491
  Authors
Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V
  Title
Fucose sensing regulates bacterial intestinal colonization.
  Journal
Nature 492:113-7 (2012)
DOI:10.1038/nature11623
Reference
PMID:22778415
  Authors
Hirakawa H, Harwood CS, Pechter KB, Schaefer AL, Greenberg EP
  Title
Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression.
  Journal
Proc Natl Acad Sci U S A 109:12141-6 (2012)
DOI:10.1073/pnas.1200243109
Reference
PMID:14617175
  Authors
Danino VE, Wilkinson A, Edwards A, Downie JA
  Title
Recipient-induced transfer of the symbiotic plasmid pRL1JI in Rhizobium leguminosarum bv. viciae is regulated by a quorum-sensing relay.
  Journal
Mol Microbiol 50:511-25 (2003)
DOI:10.1046/j.1365-2958.2003.03699.x
Reference
PMID:12448738
  Authors
Wisniewski-Dye F, Downie JA
  Title
Quorum-sensing in Rhizobium.
  Journal
Antonie Van Leeuwenhoek 81:397-407 (2002)
DOI:10.1023/A:1020501104051
Reference
PMID:10368158
  Authors
Rodelas B, Lithgow JK, Wisniewski-Dye F, Hardman A, Wilkinson A, Economou A, Williams P, Downie JA
  Title
Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae.
  Journal
J Bacteriol 181:3816-23 (1999)
DOI:10.1128/JB.181.12.3816-3823.1999
Reference
PMID:24550924
  Authors
Lang J, Faure D
  Title
Functions and regulation of quorum-sensing in Agrobacterium tumefaciens.
  Journal
Front Plant Sci 5:14 (2014)
DOI:10.3389/fpls.2014.00014
Reference
PMID:23710277
  Authors
Planamente S, Morera S, Faure D
  Title
In planta fitness-cost of the Atu4232-regulon encoding for a selective GABA-binding sensor in Agrobacterium.
  Journal
Commun Integr Biol 6:e23692 (2013)
DOI:10.4161/cib.23692
Reference
PMID:16943991
  Authors
Barnard AM, Salmond GP
  Title
Quorum sensing in Erwinia species.
  Journal
Anal Bioanal Chem 387:415-23 (2007)
DOI:10.1007/s00216-006-0701-1
Reference
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Related
pathway
btrm02040  Flagellar assembly
KO pathway
ko02024   
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