KEGG   PATHWAY: canu00983
Entry
canu00983                   Pathway                                
Name
Drug metabolism - other enzymes - Magallana angulata (Portugese oyster)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
canu00983  Drug metabolism - other enzymes
canu00983

Organism
Magallana angulata (Portugese oyster) [GN:canu]
Gene
128163965  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
128161327  inosine-5'-monophosphate dehydrogenase 1b-like isoform X1 [KO:K00088] [EC:1.1.1.205]
128188019  GMP synthase [glutamine-hydrolyzing]-like [KO:K01951] [EC:6.3.5.2]
128190687  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
128167387  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
128167388  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
128167696  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
128186627  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
128187739  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
128160434  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
128176493  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
128183107  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
128174919  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
128159000  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
128166410  LOW QUALITY PROTEIN: inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
128163485  carboxylesterase 1C-like [KO:K01044] [EC:3.1.1.1]
128164036  carboxylesterase 1C-like isoform X1 [KO:K01044] [EC:3.1.1.1]
128164044  carboxylesterase 1C-like [KO:K01044] [EC:3.1.1.1]
128164762  acetylcholinesterase-like isoform X1 [KO:K01044] [EC:3.1.1.1]
128165350  LOW QUALITY PROTEIN: fatty acyl-CoA hydrolase precursor, medium chain-like [KO:K01044] [EC:3.1.1.1]
128165351  cholinesterase 1-like [KO:K01044] [EC:3.1.1.1]
128163769  carboxylesterase 1C-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
128164761  carboxylesterase 1C-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
128165361  neuroligin-4, X-linked-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
128184222  carboxylesterase 1C-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
128172882  uncharacterized protein LOC128172882 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
128175757  uncharacterized protein LOC128175757 isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
128188162  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
128189614  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
128189894  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
128183780  thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
128183781  thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
128165909  dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
128161948  dihydropyrimidinase-like isoform X1 [KO:K01464] [EC:3.5.2.2]
128186789  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
128157375  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
128173603  uridine phosphorylase 2-like isoform X1 [KO:K00757] [EC:2.4.2.3]
128192449  uridine-cytidine kinase 2-like isoform X1 [KO:K00876] [EC:2.7.1.48]
128165387  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
128177711  thymidine kinase 2, mitochondrial-like isoform X1 [KO:K00857] [EC:2.7.1.21]
128167073  thymidine kinase, cytosolic-like isoform X1 [KO:K00857] [EC:2.7.1.21]
128167759  deoxynucleoside kinase-like [KO:K00857] [EC:2.7.1.21]
128173665  uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
128165535  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
128192082  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
128165306  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
128176757  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
128180998  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
128157184  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
128160690  deoxyuridine 5'-triphosphate nucleotidohydrolase-like isoform X1 [KO:K01520] [EC:3.6.1.23]
128160719  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
128160721  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
128162520  eosinophil peroxidase-like [KO:K10789] [EC:1.11.2.2]
128163610  peroxidasin-like [KO:K10789] [EC:1.11.2.2]
128192858  peroxidase-like protein [KO:K10789] [EC:1.11.2.2]
128181364  peroxidase-like protein [KO:K10789] [EC:1.11.2.2]
128159926  glutathione S-transferase Y1-like [KO:K00799] [EC:2.5.1.18]
128159927  glutathione S-transferase Y1-like [KO:K00799] [EC:2.5.1.18]
128160099  probable glutathione S-transferase 8 [KO:K00799] [EC:2.5.1.18]
128188965  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
128188969  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
128190194  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
128163349  glutathione S-transferase P 2-like [KO:K00799] [EC:2.5.1.18]
128190650  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
128180966  uncharacterized protein LOC128180966 [KO:K00799] [EC:2.5.1.18]
128181290  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
128181465  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
128166970  glutathione S-transferase 1-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
128167025  uncharacterized protein LOC128167025 [KO:K00799] [EC:2.5.1.18]
128183504  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
128183505  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
128155629  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
128156067  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
128186161  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
128186869  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
128186871  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
128187060  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
128187070  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
128157926  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
128188214  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
128188215  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
128188502  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
128185651  glutathione S-transferase P 1-like [KO:K23790] [EC:2.5.1.18]
128186251  glutathione S-transferase P 1-like isoform X1 [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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