KEGG   PATHWAY: cko00260
Entry
cko00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Citrobacter koseri
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cko00260  Glycine, serine and threonine metabolism
cko00260

Module
cko_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cko00260]
cko_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cko00260]
cko_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cko00260]
cko_M00555  Betaine biosynthesis, choline => betaine [PATH:cko00260]
cko_M00621  Glycine cleavage system [PATH:cko00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Citrobacter koseri [GN:cko]
Gene
CKO_03894  hypothetical protein [KO:K00928] [EC:2.7.2.4]
CKO_03385  hypothetical protein [KO:K12524] [EC:2.7.2.4 1.1.1.3]
CKO_03054  hypothetical protein [KO:K12525] [EC:2.7.2.4 1.1.1.3]
CKO_04853  hypothetical protein [KO:K00133] [EC:1.2.1.11]
CKO_03384  hypothetical protein [KO:K00872] [EC:2.7.1.39]
CKO_03383  hypothetical protein [KO:K01733] [EC:4.2.3.1]
CKO_02211  hypothetical protein [KO:K01620] [EC:4.1.2.48]
CKO_00237  hypothetical protein [KO:K00600] [EC:2.1.2.1]
CKO_02036  hypothetical protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CKO_05009  hypothetical protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
CKO_04521  hypothetical protein [KO:K00865] [EC:2.7.1.165]
CKO_04140  hypothetical protein [KO:K00865] [EC:2.7.1.165]
CKO_02381  hypothetical protein [KO:K01834] [EC:5.4.2.11]
CKO_03391  hypothetical protein [KO:K15634] [EC:5.4.2.11]
CKO_05070  hypothetical protein [KO:K15633] [EC:5.4.2.12]
CKO_04278  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CKO_02165  hypothetical protein [KO:K00831] [EC:2.6.1.52]
CKO_03400  hypothetical protein [KO:K01079] [EC:3.1.3.3]
CKO_01569  hypothetical protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
CKO_05077  hypothetical protein [KO:K00639] [EC:2.3.1.29]
CKO_05076  hypothetical protein [KO:K00060] [EC:1.1.1.103]
CKO_04266  hypothetical protein [KO:K00281] [EC:1.4.4.2]
CKO_04269  hypothetical protein [KO:K00605] [EC:2.1.2.10]
CKO_03852  hypothetical protein [KO:K00382] [EC:1.8.1.4]
CKO_03256  hypothetical protein [KO:K00382] [EC:1.8.1.4]
CKO_04268  hypothetical protein [KO:K02437]
CKO_00199  hypothetical protein [KO:K00998] [EC:2.7.8.8]
CKO_02584  hypothetical protein [KO:K00108] [EC:1.1.99.1]
CKO_02583  hypothetical protein [KO:K00130] [EC:1.2.1.8]
CKO_01706  hypothetical protein [KO:K01697] [EC:4.2.1.22]
CKO_01707  hypothetical protein [KO:K01758] [EC:4.4.1.1]
CKO_04512  hypothetical protein [KO:K01752] [EC:4.3.1.17]
CKO_04154  hypothetical protein [KO:K01752] [EC:4.3.1.17]
CKO_01166  hypothetical protein [KO:K01752] [EC:4.3.1.17]
CKO_00633  hypothetical protein [KO:K01752] [EC:4.3.1.17]
CKO_00111  hypothetical protein [KO:K01754] [EC:4.3.1.19]
CKO_04517  hypothetical protein [KO:K01754] [EC:4.3.1.19]
CKO_00021  hypothetical protein [KO:K01753] [EC:4.3.1.18]
CKO_04217  hypothetical protein [KO:K25316] [EC:5.1.1.10]
CKO_01336  hypothetical protein [KO:K01695] [EC:4.2.1.20]
CKO_01337  hypothetical protein [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cko00010  Glycolysis / Gluconeogenesis
cko00020  Citrate cycle (TCA cycle)
cko00230  Purine metabolism
cko00250  Alanine, aspartate and glutamate metabolism
cko00270  Cysteine and methionine metabolism
cko00290  Valine, leucine and isoleucine biosynthesis
cko00300  Lysine biosynthesis
cko00330  Arginine and proline metabolism
cko00460  Cyanoamino acid metabolism
cko00470  D-Amino acid metabolism
cko00564  Glycerophospholipid metabolism
cko00620  Pyruvate metabolism
cko00630  Glyoxylate and dicarboxylate metabolism
cko00640  Propanoate metabolism
cko00680  Methane metabolism
cko00860  Porphyrin metabolism
cko00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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