KEGG   PATHWAY: cns00983
Entry
cns00983                    Pathway                                
Name
Drug metabolism - other enzymes - Contarinia nasturtii (swede midge)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
cns00983  Drug metabolism - other enzymes
cns00983

Organism
Contarinia nasturtii (swede midge) [GN:cns]
Gene
116352633  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
116348854  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
116338360  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
116341334  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
116349268  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
116341296  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
116349125  neuroligin-4, Y-linked isoform X1 [KO:K01044] [EC:3.1.1.1]
116336823  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
116337234  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
116337264  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116345389  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116338942  uncharacterized protein LOC116338942 [KO:K00699] [EC:2.4.1.17]
116346043  UDP-glucuronosyltransferase 1-10-like [KO:K00699] [EC:2.4.1.17]
116346397  UDP-glucuronosyltransferase 1-7C-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116339910  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
116347346  uncharacterized protein LOC116347346 [KO:K00699] [EC:2.4.1.17]
116347456  UDP-glucuronosyltransferase 2B16-like [KO:K00699] [EC:2.4.1.17]
116340528  UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
116347721  UDP-glucuronosyltransferase 1-7C-like [KO:K00699] [EC:2.4.1.17]
116341057  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
116348740  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
116341971  UDP-glucuronosyltransferase 1-7-like [KO:K00699] [EC:2.4.1.17]
116350747  UDP-glucuronosyltransferase 3A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
116342950  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
116350844  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
116350845  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
116351113  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
116351127  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
116343238  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
116351562  UDP-glucuronosyltransferase 1-10-like [KO:K00699] [EC:2.4.1.17]
116351563  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
116351836  UDP-glucuronosyltransferase 1-10-like [KO:K00699] [EC:2.4.1.17]
116340172  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
116338131  cytidine deaminase-like isoform X1 [KO:K01489] [EC:3.5.4.5]
116342159  uncharacterized protein LOC116342159 [KO:K01489] [EC:3.5.4.5]
116339648  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
116350690  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
116346970  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
116340134  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
116346879  uridine phosphorylase 1-like isoform X1 [KO:K00757] [EC:2.4.2.3]
116347376  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
116342554  uridine-cytidine kinase isoform X1 [KO:K00876] [EC:2.7.1.48]
116348869  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
116347205  UMP-CMP kinase 2 [KO:K13800] [EC:2.7.4.14]
116346412  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
116343628  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
116344903  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
116345089  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
116339233  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
116348104  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
116348533  uncharacterized protein LOC116348533 [KO:K00940] [EC:2.7.4.6]
116342548  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
116341068  deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
116342716  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
116336559  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116336920  glutathione S-transferase D7-like [KO:K00799] [EC:2.5.1.18]
116343943  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116343944  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116343945  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
116338955  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116339232  glutathione S-transferase E14-like [KO:K00799] [EC:2.5.1.18]
116339325  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116339222  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
116347538  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116340828  glutathione S-transferase D7-like isoform X1 [KO:K00799] [EC:2.5.1.18]
116349357  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
116349504  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116342350  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116350621  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116342870  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
116351352  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
116351355  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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