KEGG   PATHWAY: cpii04150
Entry
cpii04150                   Pathway                                
Name
mTOR signaling pathway - Culex pipiens pallens (Northern house mosquito)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
cpii04150  mTOR signaling pathway
cpii04150

Organism
Culex pipiens pallens (Northern house mosquito) [GN:cpii]
Gene
120417701  Y+L amino acid transporter 2 [KO:K13780]
120427150  Y+L amino acid transporter 2 [KO:K13780]
120422953  Y+L amino acid transporter 2 [KO:K13780]
120416916  uncharacterized protein LOC120416916 [KO:K06519]
120414792  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
120418739  V-type proton ATPase subunit B [KO:K02147]
120421090  V-type proton ATPase subunit B [KO:K02147]
120430974  V-type proton ATPase subunit C [KO:K02148]
120426655  V-type proton ATPase subunit D 1 [KO:K02149]
120427332  V-type proton ATPase subunit D 1-like [KO:K02149]
120429629  V-type proton ATPase subunit D 1 [KO:K02149]
120412961  V-type proton ATPase subunit E [KO:K02150]
120426914  V-type proton ATPase subunit F [KO:K02151]
120432172  V-type proton ATPase subunit G-like [KO:K02152]
120414130  V-type proton ATPase subunit G-like [KO:K02152]
120417288  V-type proton ATPase subunit H isoform X1 [KO:K02144]
120425824  ragulator complex protein LAMTOR1 [KO:K20397]
120429251  ragulator complex protein LAMTOR3 homolog [KO:K04370]
120415790  ragulator complex protein LAMTOR4 homolog [KO:K20399]
120426522  ragulator complex protein LAMTOR5-like [KO:K16344]
120427951  ragulator complex protein LAMTOR5-like isoform X1 [KO:K16344]
120417798  folliculin [KO:K09594]
120431235  folliculin-interacting protein 1 [KO:K20401]
120413772  ras-related GTP-binding protein A [KO:K16185]
120428081  ras-related GTP-binding protein C [KO:K16186]
120419186  GATOR complex protein MIOS [KO:K20407]
120422294  nucleoporin seh1 [KO:K14299]
120416162  GATOR complex protein WDR24 [KO:K20408]
120422865  GATOR complex protein Wdr59 isoform X1 [KO:K20409]
120431381  protein SEC13 homolog [KO:K14004]
120417610  GATOR complex protein Iml1 isoform X1 [KO:K20404]
120412954  GATOR complex protein NPRL2 [KO:K20405]
120423708  GATOR complex protein NPRL3 [KO:K20406]
120420774  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
120415189  regulatory-associated protein of mTOR-like [KO:K07204]
120428089  regulatory-associated protein of mTOR [KO:K07204]
120413428  regulatory-associated protein of mTOR-like [KO:K07204]
120417544  serine/threonine-protein kinase Tor-like [KO:K07203] [EC:2.7.11.1]
120412498  serine/threonine-protein kinase Tor-like [KO:K07203] [EC:2.7.11.1]
120424286  protein LST8 homolog [KO:K08266]
120428704  TELO2-interacting protein 1 homolog [KO:K20403]
120415458  restin homolog isoform X1 [KO:K10421]
120428067  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
120432647  serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
120426741  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
120413491  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
120432601  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
120419263  eukaryotic translation initiation factor 4B [KO:K03258]
120416737  40S ribosomal protein S6-like [KO:K02991]
120417150  40S ribosomal protein S6 [KO:K02991]
120417506  40S ribosomal protein S6-like [KO:K02991]
120417347  STE20-related kinase adapter protein alpha [KO:K08271]
120424766  serine/threonine-protein kinase stk11 [KO:K07298] [EC:2.7.11.1]
120413356  protein Mo25 [KO:K08272]
120427146  hamartin [KO:K07206]
120425789  tuberin isoform X1 [KO:K07207]
120426249  TBC1 domain family member 7 [KO:K20396]
120414330  GTP-binding protein Rheb homolog [KO:K07208]
120423989  protein Wnt-1 [KO:K03209]
120414670  protein Wnt-1-like [KO:K00408]
120432010  protein Wnt-5 isoform X1 [KO:K00444]
120423995  protein Wnt-6 [KO:K00445]
120429895  protein Wnt-2 [KO:K00572]
120430276  protein Wnt-8 [KO:K00714]
120423996  protein Wnt-4 [KO:K01064]
120424990  protein Wnt-10b [KO:K01357]
120431971  protein Wnt-10a-like [KO:K01357]
120414045  frizzled [KO:K02432]
120414050  frizzled-like [KO:K02432]
120414097  frizzled-4 [KO:K02354]
120424593  frizzled-2 [KO:K02375]
120424293  frizzled-3 [KO:K04690]
120412717  low-density lipoprotein receptor-related protein 6 [KO:K03068]
120414472  segment polarity protein dishevelled isoform X1 [KO:K02353]
120415202  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
120430182  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
120421839  insulin-like [KO:K04526]
120421843  LIRP-like isoform X1 [KO:K04526]
120421844  LIRP-like isoform X1 [KO:K04526]
120422667  insulin-like receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
120430841  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
120416331  protein son of sevenless isoform X2 [KO:K03099]
120431910  GTPase HRas [KO:K07827]
120414015  GTPase HRas [KO:K07827]
120428354  raf homolog serine/threonine-protein kinase Raf isoform X1 [KO:K04365] [EC:2.7.11.1]
120413685  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
120415489  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
120417510  ribosomal protein S6 kinase 2 beta-like isoform X1 [KO:K04373] [EC:2.7.11.1]
120414058  insulin receptor substrate 1 isoform X4 [KO:K16172]
120413155  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120414150  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
120413114  serine-rich adhesin for platelets isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120414803  RAC serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120424559  stress-activated map kinase-interacting protein 1 [KO:K20410]
120432381  rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
120427031  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
120423697  protein kinase C, brain isozyme-like isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
cpii00561  Glycerolipid metabolism
cpii04140  Autophagy - animal
KO pathway
ko04150   
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