KEGG   PATHWAY: cpra00260
Entry
cpra00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Collimonas pratensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cpra00260  Glycine, serine and threonine metabolism
cpra00260

Module
cpra_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cpra00260]
cpra_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cpra00260]
cpra_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cpra00260]
cpra_M00555  Betaine biosynthesis, choline => betaine [PATH:cpra00260]
cpra_M00621  Glycine cleavage system [PATH:cpra00260]
cpra_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:cpra00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Collimonas pratensis [GN:cpra]
Gene
CPter91_3046  aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
CPter91_2435  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CPter91_3200  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CPter91_0842  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
CPter91_2959  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
CPter91_3296  ltaE; low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
CPter91_3718  serine hydroxymethyltransferase family protein [KO:K00600] [EC:2.1.2.1]
CPter91_4152  aminotransferase class-V family protein [KO:K00600] [EC:2.1.2.1]
CPter91_1406  glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
CPter91_0046  aminotransferase class-V family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
CPter91_0389  NAD binding domain of 6-phosphogluconate dehydrogenase family protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CPter91_5323  NAD binding domain of 6-phosphogluconate dehydrogenase family protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CPter91_3077  NAD binding domain of 6-phosphogluconate dehydrogenase family protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
CPter91_1468  NAD binding domain of 6-phosphogluconate dehydrogenase family protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
CPter91_4284  hypothetical protein [KO:K11529] [EC:2.7.1.165]
CPter91_5052  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
CPter91_4929  histidine phosphatase super family protein [KO:K15634] [EC:5.4.2.11]
CPter91_0426  D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CPter91_5509  putative d-3-phosphoglycerate dehydrogenase oxidoreductase protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CPter91_4601  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
CPter91_2327  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
CPter91_4156  short chain dehydrogenase family protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
CPter91_3313  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
CPter91_2615  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
CPter91_2616  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
CPter91_4383  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CPter91_2296  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CPter91_2614  gcvH; glycine cleavage system H protein [KO:K02437]
CPter91_3771  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
CPter91_1952  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
CPter91_3936  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
CPter91_3937  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
CPter91_1413  rieske [2Fe-2S] domain protein [KO:K00479] [EC:1.14.13.251]
CPter91_1414  2Fe-2S iron-sulfur cluster binding domain protein [KO:K21832] [EC:1.14.13.251]
CPter91_1409  NADH:flavin oxidoreductase / NADH oxidase family protein [KO:K21833] [EC:1.5.7.3]
CPter91_1410  hypothetical protein [KO:K21834]
CPter91_1411  electron transfer flavodomain protein [KO:K25960]
CPter91_1412  electron transfer flavodomain protein [KO:K25961]
CPter91_1437  sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
CPter91_1435  sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
CPter91_1438  sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
CPter91_1436  soxD; subunit delta of sarcosine oxidase [KO:K00304] [EC:1.5.3.24 1.5.3.1]
CPter91_2008  CBS domain protein [KO:K01697] [EC:4.2.1.22]
CPter91_2009  metC; cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
CPter91_1434  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
CPter91_0735  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
CPter91_5343  serine dehydratase-like protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
CPter91_3764  putative D-serine deaminase (D-serine dehydratase) protein [KO:K01753] [EC:4.3.1.18]
CPter91_4133  aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
CPter91_2440  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
CPter91_2439  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
CPter91_2593  2,4-diaminobutyrate 4-transaminase family protein [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cpra00010  Glycolysis / Gluconeogenesis
cpra00020  Citrate cycle (TCA cycle)
cpra00230  Purine metabolism
cpra00250  Alanine, aspartate and glutamate metabolism
cpra00270  Cysteine and methionine metabolism
cpra00290  Valine, leucine and isoleucine biosynthesis
cpra00300  Lysine biosynthesis
cpra00330  Arginine and proline metabolism
cpra00460  Cyanoamino acid metabolism
cpra00470  D-Amino acid metabolism
cpra00564  Glycerophospholipid metabolism
cpra00600  Sphingolipid metabolism
cpra00620  Pyruvate metabolism
cpra00630  Glyoxylate and dicarboxylate metabolism
cpra00640  Propanoate metabolism
cpra00680  Methane metabolism
cpra00860  Porphyrin metabolism
cpra00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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