KEGG   PATHWAY: cpw00260
Entry
cpw00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Coccidioides posadasii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cpw00260  Glycine, serine and threonine metabolism
cpw00260

Module
cpw_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cpw00260]
cpw_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cpw00260]
cpw_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cpw00260]
cpw_M00621  Glycine cleavage system [PATH:cpw00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Coccidioides posadasii [GN:cpw]
Gene
CPC735_028720  Aspartokinase, putative [KO:K00928] [EC:2.7.2.4]
CPC735_058170  aspartate-semialdehyde dehydrogenase, putative [KO:K00133] [EC:1.2.1.11]
CPC735_006180  homoserine dehydrogenase, putative [KO:K00003] [EC:1.1.1.3]
CPC735_003130  homoserine kinase, putative [KO:K00872] [EC:2.7.1.39]
CPC735_070630  threonine synthase, putative [KO:K01733] [EC:4.2.3.1]
CPC735_049980  alanine racemase TOXG, putative [KO:K01620] [EC:4.1.2.48]
CPC735_072560  threonine aldolase, putative [KO:K01620] [EC:4.1.2.48]
CPC735_046260  serine hydroxymethyltransferase, cytosolic, putative [KO:K00600] [EC:2.1.2.1]
CPC735_054190  serine hydroxymethyltransferase, cytosolic, putative [KO:K00600] [EC:2.1.2.1]
CPC735_034570  aminotransferase, class V family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
CPC735_057010  glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]
CPC735_046240  2,3-bisphosphoglycerate-independent phosphoglycerate mutase family protein [KO:K15633] [EC:5.4.2.12]
CPC735_062820  hypothetical protein [KO:K15918] [EC:2.7.1.31]
CPC735_051550  D-3-phosphoglycerate dehydrogenase, putative [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CPC735_028640  D-3-phosphoglycerate dehydrogenase 1, putative [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CPC735_037190  aminotransferase, class V family protein [KO:K00831] [EC:2.6.1.52]
CPC735_057620  phosphoserine phosphatase, putative [KO:K01079] [EC:3.1.3.3]
CPC735_056140  oxidoreductase, short chain dehydrogenase, putative [KO:K16066] [EC:1.1.1.381 1.1.1.-]
CPC735_026260  5-aminolevulinate synthase, mitochondrial precursor, putative [KO:K00643] [EC:2.3.1.37]
CPC735_005320  copper amine oxidase, putative [KO:K00276] [EC:1.4.3.21]
CPC735_026690  peroxisomal copper amine oxidase, putative [KO:K00276] [EC:1.4.3.21]
CPC735_059480  copper amine oxidase, putative [KO:K00276] [EC:1.4.3.21]
CPC735_048000  Copper amine oxidase, putative [KO:K00276] [EC:1.4.3.21]
CPC735_032690  Copper amine oxidase 1, putative [KO:K00276] [EC:1.4.3.21]
CPC735_061200  glycine dehydrogenase, putative [KO:K00281] [EC:1.4.4.2]
CPC735_033040  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
CPC735_066840  Dihydrolipoyl dehydrogenase, mitochondrial precursor, putative [KO:K00382] [EC:1.8.1.4]
CPC735_014670  glycine cleavage system H protein [KO:K02437]
CPC735_015460  D-amino acid oxidase, putative [KO:K00273] [EC:1.4.3.3]
CPC735_062000  FAD dependent oxidoreductase family protein [KO:K00273] [EC:1.4.3.3]
CPC735_027330  Amidinotransferase family protein [KO:K00613] [EC:2.1.4.1]
CPC735_047010  CDP-diacylglycerol--serine O-phosphatidyltransferase, putative [KO:K17103] [EC:2.7.8.8]
CPC735_073360  betaine aldehyde dehydrogenase, putative [KO:K00130] [EC:1.2.1.8]
CPC735_007000  conserved hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CPC735_053910  cystathionine beta-synthase, putative [KO:K01697] [EC:4.2.1.22]
CPC735_067650  Cystathionine beta-synthase, putative [KO:K01697] [EC:4.2.1.22]
CPC735_026540  Cystathionine beta-synthase, putative [KO:K01697] [EC:4.2.1.22]
CPC735_038820  cystathionine gamma-lyase, putative [KO:K01758] [EC:4.4.1.1]
CPC735_063370  threonine dehydratase, mitochondrial precursor, putative [KO:K01754] [EC:4.3.1.19]
CPC735_067580  Pyridoxal-phosphate dependent enzyme family [KO:K01754] [EC:4.3.1.19]
CPC735_019430  Pyridoxal-phosphate dependent enzyme family [KO:K17989] [EC:4.3.1.17 4.3.1.19]
CPC735_032820  hypothetical protein [KO:K20498] [EC:4.3.1.18]
CPC735_068260  tryptophan synthase, putative [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cpw00010  Glycolysis / Gluconeogenesis
cpw00020  Citrate cycle (TCA cycle)
cpw00230  Purine metabolism
cpw00250  Alanine, aspartate and glutamate metabolism
cpw00270  Cysteine and methionine metabolism
cpw00290  Valine, leucine and isoleucine biosynthesis
cpw00300  Lysine biosynthesis
cpw00330  Arginine and proline metabolism
cpw00460  Cyanoamino acid metabolism
cpw00470  D-Amino acid metabolism
cpw00564  Glycerophospholipid metabolism
cpw00600  Sphingolipid metabolism
cpw00620  Pyruvate metabolism
cpw00630  Glyoxylate and dicarboxylate metabolism
cpw00640  Propanoate metabolism
cpw00680  Methane metabolism
cpw00860  Porphyrin metabolism
cpw00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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