KEGG   PATHWAY: crg00983
Entry
crg00983                    Pathway                                
Name
Drug metabolism - other enzymes - Magallana gigas (Pacific oyster)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
crg00983  Drug metabolism - other enzymes
crg00983

Organism
Magallana gigas (Pacific oyster) [GN:crg]
Gene
105345279  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
105330403  inosine-5'-monophosphate dehydrogenase 1b isoform X4 [KO:K00088] [EC:1.1.1.205]
105329768  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
105343241  thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
105341993  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
117684753  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
105335515  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
105343239  thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
105320492  xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105322104  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105338956  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105320852  xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105320513  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105347412  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
105336052  fatty acyl-CoA hydrolase precursor, medium chain [KO:K01044] [EC:3.1.1.1]
105336054  fatty acyl-CoA hydrolase precursor, medium chain [KO:K01044] [EC:3.1.1.1]
117683537  carboxylesterase 1C-like isoform X1 [KO:K01044] [EC:3.1.1.1]
117683545  carboxylesterase 1C-like [KO:K01044] [EC:3.1.1.1]
105344276  carboxylesterase 4A [KO:K01044] [EC:3.1.1.1]
105324289  fatty acyl-CoA hydrolase precursor, medium chain isoform X1 [KO:K01044] [EC:3.1.1.1]
105320590  uncharacterized protein LOC105320590 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
105326584  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
105334462  cytidine deaminase isoform X1 [KO:K01489] [EC:3.5.4.5]
105335466  cytidine deaminase [KO:K01489] [EC:3.5.4.5]
105327548  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
105321928  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
105346767  dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
105340590  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
105332652  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
105330253  uridine phosphorylase 2 isoform X1 [KO:K00757] [EC:2.4.2.3]
105329021  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
105332762  uridine-cytidine kinase 2 isoform X2 [KO:K00876] [EC:2.7.1.48]
105348498  uridine-cytidine kinase-like 1 isoform X5 [KO:K00876] [EC:2.7.1.48]
105340134  deoxynucleoside kinase [KO:K00857] [EC:2.7.1.21]
105340334  thymidine kinase, cytosolic isoform X1 [KO:K00857] [EC:2.7.1.21]
105337973  thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
105337036  thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
105317500  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
105340736  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
105348744  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
105336299  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
105341901  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
105343795  LOW QUALITY PROTEIN: nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
105346431  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
117686725  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
105343526  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
105343546  deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
117683008  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
105333777  myeloperoxidase [KO:K10789] [EC:1.11.2.2]
117683867  peroxidasin-like [KO:K10789] [EC:1.11.2.2]
105347615  eosinophil peroxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
105319077  peroxidase-like protein [KO:K10789] [EC:1.11.2.2]
105318451  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
105331625  probable glutathione S-transferase 8 [KO:K00799] [EC:2.5.1.18]
105318598  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
105321516  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
105321029  uncharacterized protein LOC105321029 isoform X1 [KO:K00799] [EC:2.5.1.18]
105323777  glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
105323273  glutathione S-transferase 1-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
105329720  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
105330333  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
105330981  microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
105334487  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105333884  glutathione S-transferase Y1 [KO:K00799] [EC:2.5.1.18]
105338317  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
105338129  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
105338130  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
105342120  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
105333880  uncharacterized protein LOC105333880 [KO:K00799] [EC:2.5.1.18]
105337533  glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
105337535  glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
105333994  glutathione S-transferase P 2-like [KO:K00799] [EC:2.5.1.18]
105343939  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
105343940  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
105346568  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
105346569  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
105321515  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
105323979  glutathione S-transferase A [KO:K00799] [EC:2.5.1.18]
117682167  probable glutathione S-transferase 8 [KO:K00799] [EC:2.5.1.18]
105320049  glutathione S-transferase P 1 isoform X1 [KO:K23790] [EC:2.5.1.18]
105323725  glutathione S-transferase P 1 isoform X1 [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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