KEGG   PATHWAY: cvn00983
Entry
cvn00983                    Pathway                                
Name
Drug metabolism - other enzymes - Crassostrea virginica (eastern oyster)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
cvn00983  Drug metabolism - other enzymes
cvn00983

Organism
Crassostrea virginica (eastern oyster) [GN:cvn]
Gene
111111216  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
111106862  inosine-5'-monophosphate dehydrogenase 1-like isoform X1 [KO:K00088] [EC:1.1.1.205]
111107099  inosine-5'-monophosphate dehydrogenase 1-like isoform X1 [KO:K00088] [EC:1.1.1.205]
111134455  GMP synthase [glutamine-hydrolyzing]-like [KO:K01951] [EC:6.3.5.2]
111122055  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
111132977  thiopurine S-methyltransferase-like isoform X1 [KO:K00569] [EC:2.1.1.67]
111132978  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
111119129  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
111119130  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
111119306  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
111119308  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
111119309  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
111105600  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111131269  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111107393  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111108476  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111136587  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111129061  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111118672  inosine triphosphate pyrophosphatase-like isoform X1 [KO:K01519] [EC:3.6.1.66]
111118714  inosine triphosphate pyrophosphatase-like isoform X1 [KO:K01519] [EC:3.6.1.66]
111121705  LOW QUALITY PROTEIN: carboxylesterase 1C-like [KO:K01044] [EC:3.1.1.1]
111112312  carboxylesterase 1C-like isoform X1 [KO:K01044] [EC:3.1.1.1]
111112314  carboxylesterase 1C-like [KO:K01044] [EC:3.1.1.1]
111112315  liver carboxylesterase-like [KO:K01044] [EC:3.1.1.1]
111112948  carboxylesterase 1C-like [KO:K01044] [EC:3.1.1.1]
111113400  carboxylesterase 1C-like [KO:K01044] [EC:3.1.1.1]
111115566  carboxylesterase 1C-like isoform X1 [KO:K01044] [EC:3.1.1.1]
111118846  LOW QUALITY PROTEIN: liver carboxylesterase 2-like [KO:K01044] [EC:3.1.1.1]
111104316  carboxylesterase 1C-like [KO:K01044] [EC:3.1.1.1]
111120469  LOW QUALITY PROTEIN: cocaine esterase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
111108533  uncharacterized protein LOC111108533 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
111108571  uncharacterized protein LOC111108571 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
111109028  uncharacterized protein LOC111109028 isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
111109043  uncharacterized protein LOC111109043 isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
111112310  LOW QUALITY PROTEIN: acetylcholinesterase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
111115698  acetylcholinesterase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
111135080  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
111136709  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
111138152  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
111138297  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
111102818  thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
111103795  thymidine phosphorylase-like isoform X1 [KO:K00758] [EC:2.4.2.4]
111103796  thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
111119483  dihydropyrimidine dehydrogenase [NADP(+)]-like [KO:K00207] [EC:1.3.1.2]
111127104  LOW QUALITY PROTEIN: dihydropyrimidinase-like [KO:K01464] [EC:3.5.2.2]
111132068  beta-ureidopropionase-like isoform X1 [KO:K01431] [EC:3.5.1.6]
111136918  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
111122716  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
111099975  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
111120502  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
111123054  uridine-cytidine kinase 2-like isoform X1 [KO:K00876] [EC:2.7.1.48]
111126502  uridine-cytidine kinase 2-like isoform X1 [KO:K00876] [EC:2.7.1.48]
111130674  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
111106556  thymidine kinase 2, mitochondrial-like isoform X1 [KO:K00857] [EC:2.7.1.21]
111106705  thymidine kinase 2, mitochondrial-like isoform X1 [KO:K00857] [EC:2.7.1.21]
111121137  LOW QUALITY PROTEIN: thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
111106799  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
111106974  thymidine kinase 2, mitochondrial-like isoform X1 [KO:K00857] [EC:2.7.1.21]
111127815  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
111118028  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
111132766  LOW QUALITY PROTEIN: uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
111118263  LOW QUALITY PROTEIN: UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
111124500  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
111127434  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
111122251  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
111118358  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
111136057  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
111126109  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
111129228  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
111105981  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
111105982  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like isoform X1 [KO:K01520] [EC:3.6.1.23]
111108617  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
111109808  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
111123883  peroxidase-like protein [KO:K10789] [EC:1.11.2.2]
111114088  peroxidase-like protein 3 [KO:K10789] [EC:1.11.2.2]
111099498  myeloperoxidase-like isoform X1 [KO:K10789] [EC:1.11.2.2]
111099865  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
111099927  myeloperoxidase-like isoform X1 [KO:K10789] [EC:1.11.2.2]
111101154  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
111101742  myeloperoxidase-like isoform X1 [KO:K10789] [EC:1.11.2.2]
111102226  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
111104644  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
111106298  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
111121161  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111121254  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
111121438  LOW QUALITY PROTEIN: glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
111132346  uncharacterized protein LOC111132346 [KO:K00799] [EC:2.5.1.18]
111133503  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
111133846  glutathione S-transferase U21-like [KO:K00799] [EC:2.5.1.18]
111134208  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
111110445  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111110471  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
111110789  LOW QUALITY PROTEIN: glutathione S-transferase P 2-like [KO:K00799] [EC:2.5.1.18]
111135121  LOW QUALITY PROTEIN: glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
111136310  LOW QUALITY PROTEIN: glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
111126505  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
111136475  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
111136792  LOW QUALITY PROTEIN: glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
111136840  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111115554  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111126974  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111116885  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
111138098  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
111138120  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
111138414  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
111102975  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
111104070  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
111105347  glutathione S-transferase P 1-like [KO:K23790] [EC:2.5.1.18]
111105513  glutathione S-transferase P 1-like isoform X1 [KO:K23790] [EC:2.5.1.18]
111103987  glutathione S-transferase P 1-like [KO:K23790] [EC:2.5.1.18]
111104156  glutathione S-transferase P 1-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

DBGET integrated database retrieval system