KEGG   PATHWAY: dci04144
Entry
dci04144                    Pathway                                
Name
Endocytosis - Diaphorina citri (Asian citrus psyllid)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
dci04144  Endocytosis
dci04144

Other DBs
GO: 0006897
Organism
Diaphorina citri (Asian citrus psyllid) [GN:dci]
Gene
103507122  ADP-ribosylation factor 6 [KO:K07941]
103519244  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00889] [EC:2.7.1.68]
103506746  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X2 [KO:K00889] [EC:2.7.1.68]
103507318  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00889] [EC:2.7.1.68]
103506794  dynamin [KO:K01528] [EC:3.6.5.5]
103518185  clathrin heavy chain-like [KO:K04646]
103516257  LOW QUALITY PROTEIN: AP-2 complex subunit alpha [KO:K11824]
103516008  AP-2 complex subunit mu isoform X1 [KO:K11826]
103524499  AP-2 complex subunit sigma [KO:K11827]
103508447  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
103524460  uncharacterized protein LOC103524460 isoform X1 [KO:K04679]
103506274  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103524925  fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
103524754  E3 ubiquitin-protein ligase CBL-B [KO:K04707] [EC:2.3.2.27]
103510242  uncharacterized protein LOC103510242 [KO:K11247]
103511750  endophilin-A-like [KO:K11247]
103509012  endophilin-B2 isoform X1 [KO:K11248]
103516683  myc box-dependent-interacting protein 1 [KO:K12562]
103514798  epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
113466219  uncharacterized protein LOC113466219 [KO:K10591] [EC:2.3.2.26]
103508446  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
103518718  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
103518719  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
103510016  TNF receptor-associated factor 6-like isoform X2 [KO:K03175] [EC:2.3.2.27]
103519609  E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
103511346  E3 ubiquitin-protein ligase SMURF1-like [KO:K04678] [EC:2.3.2.26]
103512873  E3 ubiquitin-protein ligase Su(dx) [KO:K05633] [EC:2.3.2.26]
103519341  beta-adrenergic receptor kinase 1-like [KO:K00910] [EC:2.7.11.15]
103515681  G protein-coupled receptor kinase 2 [KO:K08291] [EC:2.7.11.16]
103512230  beta-arrestin arr-1-like [KO:K04439]
103512255  neural Wiskott-Aldrich syndrome protein [KO:K23612]
103511137  actin-related protein 2-like [KO:K17260]
103520727  LOW QUALITY PROTEIN: actin-related protein 3-like [KO:K18584]
103512627  actin-related protein 3 [KO:K18584]
103521746  actin-related protein 2/3 complex subunit 2 [KO:K05758]
103521067  actin-related protein 2/3 complex subunit 2 [KO:K05758]
103519234  actin-related protein 2/3 complex subunit 3 [KO:K05756]
103508476  actin-related protein 2/3 complex subunit 4 [KO:K05755]
103508511  actin-related protein 2/3 complex subunit 5 isoform X1 [KO:K05754]
103513939  heat shock protein 70 A1-like isoform X1 [KO:K03283]
103513940  heat shock protein 70 A1-like [KO:K03283]
103513941  heat shock protein 70 A1-like [KO:K03283]
103513952  heat shock protein 68-like [KO:K03283]
103522980  heat shock 70 kDa protein cognate 4 [KO:K03283]
103523236  heat shock 70 kDa protein cognate 4-like [KO:K03283]
103506759  heat shock 70 kDa protein cognate 2-like [KO:K03283]
103507632  heat shock 70 kDa protein cognate 4-like [KO:K03283]
103524945  heat shock 70 kDa protein cognate 2-like isoform X1 [KO:K03283]
103510637  heat shock 70 kDa protein cognate 4 [KO:K03283]
103506916  WASH complex subunit 4 [KO:K18465]
103521064  WASH complex subunit 5-like [KO:K18464]
103515959  WASH complex subunit 1 [KO:K18461]
103513559  WASH complex subunit 3 [KO:K18463]
103511100  F-actin-capping protein subunit alpha [KO:K10364]
103516217  F-actin-capping protein subunit beta isoform X1 [KO:K10365]
113470806  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 29-like [KO:K18467]
103517419  vacuolar protein sorting-associated protein 29 [KO:K18467]
103508368  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
103505696  vacuolar protein sorting-associated protein 35 [KO:K18468]
103514182  sorting nexin-12 [KO:K17918]
103519592  STAM-binding protein-like [KO:K11866] [EC:3.4.19.12]
103513617  ras-related protein Rab-7a [KO:K07897]
103509025  hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
103505134  tumor susceptibility gene 101 protein [KO:K12183]
103505665  multivesicular body subunit 12B [KO:K12186]
103505171  vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
103506332  vacuolar protein sorting-associated protein 37A isoform X2 [KO:K12185]
103507756  vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
103519133  vacuolar-sorting protein SNF8 [KO:K12188]
103511325  vacuolar protein-sorting-associated protein 36 [KO:K12190]
103516058  vacuolar protein-sorting-associated protein 25 [KO:K12189]
103513114  charged multivesicular body protein 6 [KO:K12195]
103507316  charged multivesicular body protein 4c isoform X1 [KO:K12194]
103518178  charged multivesicular body protein 2a isoform X1 [KO:K12191]
103511298  charged multivesicular body protein 2b [KO:K12192]
103513403  charged multivesicular body protein 7 [KO:K15053]
103512383  vacuolar protein sorting-associated protein 4B [KO:K12196]
103522371  vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
103509201  vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
103517788  charged multivesicular body protein 1b [KO:K12197]
113468588  charged multivesicular body protein 5 [KO:K12198]
103512877  IST1 homolog [KO:K19476]
113468916  IST1 homolog [KO:K19476]
103515635  programmed cell death 6-interacting protein [KO:K12200]
103509123  programmed cell death 6-interacting protein [KO:K12200]
103520152  sorting nexin-2-like [KO:K17917]
103510348  sorting nexin-6 isoform X1 [KO:K17920]
103518579  tyrosine-protein kinase Src64B [KO:K05704] [EC:2.7.10.2]
103520303  ras-like GTP-binding protein Rho1 [KO:K04513]
103510737  ras-like GTP-binding protein Rho1 [KO:K04513]
103505516  folate receptor gamma-like isoform X1 [KO:K13649]
103505529  folate receptor beta-like [KO:K13649]
103511204  ras-related protein Rab-5C [KO:K07889]
103520383  rab GTPase-binding effector protein 1 [KO:K12480]
103514038  rabenosyn-5 [KO:K12481]
103505065  RUN and FYVE domain-containing protein 2-like isoform X1 [KO:K12482]
103506373  LOW QUALITY PROTEIN: EH domain-containing protein 1-like [KO:K12483]
103506863  EH domain-containing protein 1 [KO:K12483]
103508681  vacuolar protein sorting-associated protein 45 [KO:K12479]
103510043  ras-related protein Rab-10 [KO:K07903]
103515406  ras-related protein Rab-8B isoform X1 [KO:K07901]
103507763  ras-related protein Rab-35 [KO:K07876]
103507764  ras-related protein Rab-35-like [KO:K07876]
103511752  ras-related protein Rab-11A [KO:K07904]
103511370  rab11 family-interacting protein 5 [KO:K12484]
103508915  kinesin heavy chain [KO:K10396]
103516461  partitioning defective 3 homolog [KO:K04237]
103515070  atypical protein kinase C [KO:K06069] [EC:2.7.11.13]
103508197  cdc42 homolog [KO:K04393]
103512716  ARF GTPase-activating protein GIT2 [KO:K12487]
103512657  arfGAP with SH3 domain, ANK repeat and PH domain-containing protein [KO:K12488]
103520556  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 [KO:K12489]
103510645  centaurin-gamma-1A [KO:K12491]
103520023  ADP-ribosylation factor GTPase-activating protein 1 [KO:K12492]
103524818  ADP-ribosylation factor GTPase-activating protein 2-like [KO:K12493]
103511171  LOW QUALITY PROTEIN: Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1-like [KO:K18443]
103505473  ADP-ribosylation factor 1-like [KO:K07937]
103505457  ADP-ribosylation factor 1 [KO:K07937]
103509927  ADP-ribosylation factor 4 [KO:K07937]
103520029  ADP-ribosylation factor 2-like [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
dci04070  Phosphatidylinositol signaling system
dci04130  SNARE interactions in vesicular transport
dci04142  Lysosome
dci04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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