KEGG   PATHWAY: dmn00983
Entry
dmn00983                    Pathway                                
Name
Drug metabolism - other enzymes - Drosophila miranda
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
dmn00983  Drug metabolism - other enzymes
dmn00983

Organism
Drosophila miranda [GN:dmn]
Gene
108164632  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
108161886  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
108153844  indole-3-acetaldehyde oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
108156882  indole-3-acetaldehyde oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
108156883  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
108156958  indole-3-acetaldehyde oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
108156959  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
108154180  xanthine dehydrogenase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
108160859  abscisic-aldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
108161967  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
108151116  esterase-5B [KO:K01044] [EC:3.1.1.1]
117185731  esterase-5A [KO:K01044] [EC:3.1.1.1]
108150922  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
108158481  UDP-glucuronosyltransferase 2B13 [KO:K00699] [EC:2.4.1.17]
108158482  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
108162131  UDP-glucuronosyltransferase 1-7C-like [KO:K00699] [EC:2.4.1.17]
108162132  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
108162133  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
108155935  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
108155937  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
108155938  UDP-glucuronosyltransferase 1-9 [KO:K00699] [EC:2.4.1.17]
108155941  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
108161271  UDP-glucuronosyltransferase 1-3 [KO:K00699] [EC:2.4.1.17]
108161706  UDP-glucuronosyltransferase 2B17 isoform X1 [KO:K00699] [EC:2.4.1.17]
108161707  2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K00699] [EC:2.4.1.17]
108162420  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
108162620  UDP-glucuronosyltransferase 1-1 [KO:K00699] [EC:2.4.1.17]
108162981  UDP-glucuronosyltransferase 2B13 [KO:K00699] [EC:2.4.1.17]
108157677  UDP-glucuronosyltransferase 2B15 [KO:K00699] [EC:2.4.1.17]
108157690  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
108162963  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
108164069  uncharacterized protein LOC108164069 [KO:K00699] [EC:2.4.1.17]
108164271  UDP-glucuronosyltransferase 1-1 [KO:K00699] [EC:2.4.1.17]
117185901  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
117191333  UDP-glucuronosyltransferase 2B14-like isoform X1 [KO:K00699] [EC:2.4.1.17]
108160036  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
108160037  beta-glucuronidase isoform X2 [KO:K01195] [EC:3.2.1.31]
108162789  cytidine deaminase [KO:K01489] [EC:3.5.4.5]
108162791  cytidine deaminase [KO:K01489] [EC:3.5.4.5]
108162785  cytidine deaminase [KO:K01489] [EC:3.5.4.5]
108153085  dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
108155146  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
117186307  beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
108155544  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
108156478  uridine phosphorylase 1 isoform X2 [KO:K00757] [EC:2.4.2.3]
108153671  uridine phosphorylase 1-like [KO:K00757] [EC:2.4.2.3]
108157406  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
108165276  uridine and thymidine phosphorylase-like [KO:K00757] [EC:2.4.2.3]
108154839  uridine-cytidine kinase isoform X2 [KO:K00876] [EC:2.7.1.48]
108159957  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
117187067  uridine-cytidine kinase-like isoform X1 [KO:K00876] [EC:2.7.1.48]
117187480  uridine-cytidine kinase-like isoform X1 [KO:K00876] [EC:2.7.1.48]
108154234  uridine-cytidine kinase-like [KO:K00876] [EC:2.7.1.48]
117185740  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
108156469  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
108154730  UMP-CMP kinase 2-like [KO:K13800] [EC:2.7.4.14]
108155065  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
108163451  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
108158498  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
117192571  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
108154643  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
108155509  uncharacterized protein LOC108155509 [KO:K00940] [EC:2.7.4.6]
108164535  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
108155112  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
108162911  deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
117188954  deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
108156165  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
108158669  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
108158180  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
108158183  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
108164123  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
108164131  microsomal glutathione S-transferase 1 isoform X2 [KO:K00799] [EC:2.5.1.18]
108157249  glutathione S-transferase D7 isoform X1 [KO:K00799] [EC:2.5.1.18]
108164937  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
108158812  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
108158813  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
108155740  uncharacterized protein LOC108155740 isoform X1 [KO:K00799] [EC:2.5.1.18]
108159403  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
108156618  glutathione S-transferase D4-like [KO:K00799] [EC:2.5.1.18]
108156619  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
108156620  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
108156621  glutathione S-transferase D7-like [KO:K00799] [EC:2.5.1.18]
108160370  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
108160371  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
108160372  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
108160373  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
108160757  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
108160903  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
108160020  glutathione S-transferase E14 [KO:K00799] [EC:2.5.1.18]
108157634  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
108157651  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
108162242  microsomal glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
117190736  glutathione S-transferase E14-like [KO:K00799] [EC:2.5.1.18]
117192246  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
117193050  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
117193655  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
117193767  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

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