KEGG   PATHWAY: dse04150
Entry
dse04150                    Pathway                                
Name
mTOR signaling pathway - Drosophila sechellia
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
dse04150  mTOR signaling pathway
dse04150

Organism
Drosophila sechellia [GN:dse]
Gene
6605718  Y+L amino acid transporter 2 [KO:K13780]
6617135  large neutral amino acids transporter small subunit 1 [KO:K13780]
6617703  large neutral amino acids transporter small subunit 1 [KO:K13780]
6614311  uncharacterized protein LOC6614311 isoform X1 [KO:K06519]
6617783  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
6617785  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
6617782  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
6606641  V-type proton ATPase subunit B [KO:K02147]
6609433  V-type proton ATPase subunit C isoform X3 [KO:K02148]
6608793  probable V-type proton ATPase subunit D 2 [KO:K02149]
6609298  V-type proton ATPase subunit D 1 [KO:K02149]
6616159  probable V-type proton ATPase subunit D 2 [KO:K02149]
6613973  V-type proton ATPase subunit E [KO:K02150]
6609313  V-type proton ATPase subunit F 1 [KO:K02151]
6614065  probable V-type proton ATPase subunit F 2 [KO:K02151]
6619055  V-type proton ATPase subunit G [KO:K02152]
6614412  V-type proton ATPase subunit H isoform X1 [KO:K02144]
6619444  uncharacterized protein LOC6619444 [KO:K20397]
6609798  ragulator complex protein LAMTOR2 homolog [KO:K20398]
6614489  ragulator complex protein LAMTOR3 homolog [KO:K04370]
6610674  ragulator complex protein LAMTOR4 homolog [KO:K20399]
6616033  uncharacterized protein LOC6616033 [KO:K16344]
6611109  folliculin [KO:K09594]
6606041  folliculin-interacting protein 1 isoform X2 [KO:K20401]
6607178  ras-related GTP-binding protein A [KO:K16185]
6608131  ras-related GTP-binding protein C [KO:K16186]
6613058  GATOR complex protein MIOS [KO:K20407]
6608097  nucleoporin seh1 [KO:K14299]
6612735  GATOR complex protein WDR24 isoform X1 [KO:K20408]
6612117  GATOR complex protein Wdr59 [KO:K20409]
6607568  protein SEC13 homolog [KO:K14004]
6610337  GATOR complex protein Iml1 isoform X1 [KO:K20404]
6618006  GATOR complex protein NPRL2 [KO:K20405]
6605628  GATOR complex protein NPRL3 isoform X2 [KO:K20406]
6613812  S-phase kinase-associated protein 2 [KO:K03875]
116801997  regulatory-associated protein of mTOR [KO:K07204]
6617786  serine/threonine-protein kinase Tor [KO:K07203] [EC:2.7.11.1]
6617471  protein LST8 homolog [KO:K08266]
6607049  TELO2-interacting protein 1 homolog [KO:K20403]
6614473  restin homolog isoform X1 [KO:K10421]
6608126  phosphatidate phosphatase LPIN3 isoform X2 [KO:K15728] [EC:3.1.3.4]
6605491  serine/threonine-protein kinase unc-51 isoform X1 [KO:K08269] [EC:2.7.11.1]
6612635  eukaryotic translation initiation factor 4E1 [KO:K03259]
6615946  uncharacterized protein LOC6615946 [KO:K03259]
6605020  eukaryotic translation initiation factor 4E1 isoform X1 [KO:K03259]
6607676  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
6604784  eukaryotic translation initiation factor 4E1 [KO:K03259]
6604843  eukaryotic translation initiation factor 4E1 [KO:K03259]
6610921  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
116801014  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
116800356  putative serine/threonine-protein kinase STE20-like isoform X1 [KO:K08271]
6606498  serine/threonine-protein kinase stk11 [KO:K07298] [EC:2.7.11.1]
6605989  protein Mo25 [KO:K08272]
6615977  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
6607685  hamartin [KO:K07206]
6616239  tuberin [KO:K07207]
6607695  TBC1 domain family member 7 [KO:K20396]
6621850  GTP-binding protein Rheb homolog [KO:K07208]
6611514  protein wingless [KO:K03209]
6614874  protein Wnt-5 [KO:K00444]
6611515  protein Wnt-2 [KO:K00445]
6606552  wnt inhibitor of Dorsal protein [KO:K00714]
6611517  protein Wnt-7b isoform X3 [KO:K01357]
6605658  frizzled [KO:K02432]
6618967  frizzled-4 [KO:K02354]
6618392  frizzled-2 [KO:K02375]
6615901  frizzled-3 isoform X1 [KO:K04690]
6609007  low-density lipoprotein receptor-related protein 6 [KO:K03068]
6617660  segment polarity protein dishevelled [KO:K02353]
6612977  putative glycogen synthase kinase-3 homolog [KO:K03083] [EC:2.7.11.26]
6620798  cyclin-dependent kinase 11B isoform X1 [KO:K03083] [EC:2.7.11.26]
6606172  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
6605102  probable insulin-like peptide 2 [KO:K04526]
6605104  probable insulin-like peptide 4 [KO:K04526]
6605107  probable insulin-like peptide 5 [KO:K04526]
6616142  probable insulin-like peptide 6 [KO:K05459]
6614334  insulin-like receptor [KO:K05087] [EC:2.7.10.1]
6611201  protein son of sevenless [KO:K03099]
6616144  raf homolog serine/threonine-protein kinase Raf [KO:K04365] [EC:2.7.11.1]
6620447  dual specificity mitogen-activated protein kinase kinase dSOR1 isoform X1 [KO:K04368] [EC:2.7.12.2]
6620522  mitogen-activated protein kinase ERK-A isoform X1 [KO:K04371] [EC:2.7.11.24]
6620343  ribosomal protein S6 kinase 2 beta [KO:K04373] [EC:2.7.11.1]
6611937  insulin receptor substrate 1 [KO:K16172]
6621105  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
6619237  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
6611942  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
6610130  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
6606164  RAC serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
6609145  stress-activated map kinase-interacting protein 1 [KO:K20410]
6614975  rapamycin-insensitive companion of mTOR [KO:K08267]
6609372  ras-like GTP-binding protein Rho1 [KO:K04513]
6609518  protein kinase C, brain isozyme isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
dse00561  Glycerolipid metabolism
dse04140  Autophagy - animal
KO pathway
ko04150   
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