KEGG   PATHWAY: eln00260
Entry
eln00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Escherichia coli O83:H1 NRG 857C (AIEC)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
eln00260  Glycine, serine and threonine metabolism
eln00260

Module
eln_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:eln00260]
eln_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:eln00260]
eln_M00555  Betaine biosynthesis, choline => betaine [PATH:eln00260]
eln_M00621  Glycine cleavage system [PATH:eln00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Escherichia coli O83:H1 NRG 857C (AIEC) [GN:eln]
Gene
NRG857_20105  aspartate kinase III [KO:K00928] [EC:2.7.2.4]
NRG857_00015  thrA; bifunctional aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
NRG857_19670  metL; bifunctional aspartate kinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
NRG857_17035  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
NRG857_00020  homoserine kinase [KO:K00872] [EC:2.7.1.39]
NRG857_00025  threonine synthase [KO:K01733] [EC:4.2.3.1]
NRG857_03930  L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
NRG857_12665  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NRG857_04980  putative dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
NRG857_17690  2-ketoaldonate reductase/glyoxylate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
NRG857_02430  glycerate kinase II [KO:K00865] [EC:2.7.1.165]
NRG857_15515  glycerate kinase I [KO:K00865] [EC:2.7.1.165]
NRG857_21860  putative glycerate kinase GclK [KO:K00865] [EC:2.7.1.165]
NRG857_03340  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
NRG857_22235  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
NRG857_17970  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
NRG857_13890  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NRG857_14295  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NRG857_04130  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
NRG857_22190  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
NRG857_07625  3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
NRG857_17995  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
NRG857_17990  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
NRG857_14250  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
NRG857_14260  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
NRG857_00605  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
NRG857_20265  putative pyridine nucleotide-disulfide oxidoreductase [KO:K00382] [EC:1.8.1.4]
NRG857_14255  glycine cleavage system protein H [KO:K02437]
NRG857_12840  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
NRG857_01525  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
NRG857_01530  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
NRG857_09070  L-serine deaminase I [KO:K01752] [EC:4.3.1.17]
NRG857_13700  L-serine deaminase II [KO:K01752] [EC:4.3.1.17]
NRG857_15475  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
NRG857_15500  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
NRG857_18740  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
NRG857_11890  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
NRG857_14030  putative racemase [KO:K25316] [EC:5.1.1.10]
NRG857_06470  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
NRG857_06475  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
eln00010  Glycolysis / Gluconeogenesis
eln00020  Citrate cycle (TCA cycle)
eln00230  Purine metabolism
eln00250  Alanine, aspartate and glutamate metabolism
eln00270  Cysteine and methionine metabolism
eln00290  Valine, leucine and isoleucine biosynthesis
eln00300  Lysine biosynthesis
eln00330  Arginine and proline metabolism
eln00460  Cyanoamino acid metabolism
eln00470  D-Amino acid metabolism
eln00564  Glycerophospholipid metabolism
eln00600  Sphingolipid metabolism
eln00620  Pyruvate metabolism
eln00630  Glyoxylate and dicarboxylate metabolism
eln00640  Propanoate metabolism
eln00680  Methane metabolism
eln00860  Porphyrin metabolism
eln00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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