KEGG   PATHWAY: epr00260
Entry
epr00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Erwinia pyrifoliae DSM 12163
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
epr00260  Glycine, serine and threonine metabolism
epr00260

Module
epr_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:epr00260]
epr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:epr00260]
epr_M00555  Betaine biosynthesis, choline => betaine [PATH:epr00260]
epr_M00621  Glycine cleavage system [PATH:epr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Erwinia pyrifoliae DSM 12163 [GN:epr]
Gene
EPYR_03591  lysC; lysine-sensitive aspartokinase III [KO:K00928] [EC:2.7.2.4]
EPYR_00726  thrA; bifunctional aspartokinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
EPYR_00160  metL; bifunctional aspartokinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
EPYR_03719  asd; Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) [KO:K00133] [EC:1.2.1.11]
EPYR_00727  thrB; thrB [KO:K00872] [EC:2.7.1.39]
EPYR_00728  thrC; Threonine synthase, Pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
EPYR_02482  ltaA; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EPYR_01084  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EPYR_01573  yiaE; putative dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
EPYR_03941  yiaE; putative dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
EPYR_03079  glxK; glxK [KO:K00865] [EC:2.7.1.165]
EPYR_02617  gpmA; phosphoglyceromutase 1 [KO:K01834] [EC:5.4.2.11]
EPYR_00718  gpmB; phosphoglyceromutase 2 [KO:K15634] [EC:5.4.2.11]
EPYR_03190  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EPYR_02454  serC; 3-phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
EPYR_00701  serB; 3-phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
EPYR_01985  ydfG; putative oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
EPYR_03178  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
EPYR_03180  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
EPYR_00836  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
EPYR_03179  gcvH; glycine cleavage system H protein [KO:K02437]
EPYR_03348  hsvA; hrp-associated systemic virulence protein HsvA [KO:K00613] [EC:2.1.4.1]
EPYR_00119  hsvA; hrp-associated systemic virulence protein HsvA [KO:K00613] [EC:2.1.4.1]
EPYR_00954  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
EPYR_02018  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
EPYR_02019  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
EPYR_01724  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
EPYR_00183  ilvA; threonine dehydratase biosynthetic (threonine deaminase), Pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
EPYR_01795  trpA; trpA [KO:K01695] [EC:4.2.1.20]
EPYR_01796  trpB; Tryptophan synthase, beta chain,Pyridoxal-phosphate dependent enzyme [KO:K01696] [EC:4.2.1.20]
EPYR_00473  dat; diaminobutyrate-2-oxoglutarateaminotransferase [KO:K00836] [EC:2.6.1.76]
EPYR_03489  dfoJ; putative decarboxylase involved in desferrioxamine biosynthesis [KO:K13745] [EC:4.1.1.86]
EPYR_00474  ddc; L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
epr00010  Glycolysis / Gluconeogenesis
epr00020  Citrate cycle (TCA cycle)
epr00230  Purine metabolism
epr00250  Alanine, aspartate and glutamate metabolism
epr00270  Cysteine and methionine metabolism
epr00290  Valine, leucine and isoleucine biosynthesis
epr00300  Lysine biosynthesis
epr00330  Arginine and proline metabolism
epr00460  Cyanoamino acid metabolism
epr00470  D-Amino acid metabolism
epr00564  Glycerophospholipid metabolism
epr00600  Sphingolipid metabolism
epr00620  Pyruvate metabolism
epr00630  Glyoxylate and dicarboxylate metabolism
epr00640  Propanoate metabolism
epr00680  Methane metabolism
epr00860  Porphyrin metabolism
epr00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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