KEGG   PATHWAY: epz00982
Entry
epz00982                    Pathway                                
Name
Drug metabolism - cytochrome P450 - Equus przewalskii (Przewalski's horse)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
epz00982  Drug metabolism - cytochrome P450
epz00982

Organism
Equus przewalskii (Przewalski's horse) [GN:epz]
Gene
103554006  dimethylaniline monooxygenase [N-oxide-forming] 5-like [KO:K00485] [EC:1.14.13.8 1.8.1.-]
103550801  dimethylaniline monooxygenase [N-oxide-forming] 3 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
103564452  dimethylaniline monooxygenase [N-oxide-forming] 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
103561256  FMO2; flavin containing monooxygenase 2 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
103561257  FMO1; flavin containing monooxygenase 1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
103561258  FMO4; flavin containing monooxygenase 4 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
103544321  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
103544337  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
103549793  GSTO1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
103549794  GSTO2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
103547342  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
103553247  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
103553249  GSTA4; glutathione S-transferase alpha 4 [KO:K00799] [EC:2.5.1.18]
103551021  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
103557993  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
103557994  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
103557534  GSTM3; glutathione S-transferase mu 3 [KO:K00799] [EC:2.5.1.18]
103557535  GSTM4; glutathione S-transferase mu 4 [KO:K00799] [EC:2.5.1.18]
103557536  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
103557537  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
103560741  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
103561732  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
103544102  glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
103561728  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
103543521  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
103560039  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
103562806  GSTK1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
103552392  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
103541640  alcohol dehydrogenase E chain-like [KO:K13951] [EC:1.1.1.1]
103567542  alcohol dehydrogenase S chain [KO:K13951] [EC:1.1.1.1]
103542862  ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
103553731  ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
103544018  alcohol dehydrogenase 6-like [KO:K13952] [EC:1.1.1.1]
103544300  aldehyde dehydrogenase family 3 member B2-like [KO:K00129] [EC:1.2.1.5]
103543617  aldehyde dehydrogenase family 3 member B1-like [KO:K00129] [EC:1.2.1.5]
103540930  ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]
103540167  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
103565966  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
103541147  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
103543311  aldehyde oxidase 2-like [KO:K00157] [EC:1.2.3.1]
103565309  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
103565311  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
103557632  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
103557635  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
103557636  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
103562723  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
103562724  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
103562727  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
103567365  UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]
103567068  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
103555982  UDP-glucuronosyltransferase 1-10-like [KO:K00699] [EC:2.4.1.17]
103543749  UDP-glucuronosyltransferase 1-10-like [KO:K00699] [EC:2.4.1.17]
103552315  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
103556383  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
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