KEGG   PATHWAY: fkr00260
Entry
fkr00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Fusarium keratoplasticum
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
fkr00260  Glycine, serine and threonine metabolism
fkr00260

Module
fkr_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:fkr00260]
fkr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:fkr00260]
fkr_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:fkr00260]
fkr_M00621  Glycine cleavage system [PATH:fkr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Fusarium keratoplasticum [GN:fkr]
Gene
NCS57_00963400  Aspartokinase [KO:K00928] [EC:2.7.2.4]
NCS57_01116200  Aspartokinase [KO:K00928] [EC:2.7.2.4]
NCS57_00963500  Semialdhyde-dh domain-containing protein [KO:K00133] [EC:1.2.1.11]
NCS57_00406800  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
NCS57_01214200  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
NCS57_00297100  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
NCS57_00756900  Homoserine kinase [KO:K00872] [EC:2.7.1.39]
NCS57_00212600  hypothetical protein [KO:K01733] [EC:4.2.3.1]
NCS57_01020900  Beta-elim-lyase domain-containing protein [KO:K01620] [EC:4.1.2.48]
NCS57_00343000  Beta-elim-lyase domain-containing protein [KO:K01620] [EC:4.1.2.48]
NCS57_00806700  Beta-elim-lyase domain-containing protein [KO:K01620] [EC:4.1.2.48]
NCS57_00812500  Alanine racemase [KO:K01620] [EC:4.1.2.48]
NCS57_00378800  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NCS57_00561400  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NCS57_00714800  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
NCS57_00690800  hypothetical protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
NCS57_00905000  hypothetical protein [KO:K00865] [EC:2.7.1.165]
NCS57_00579100  Phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
NCS57_00172100  hypothetical protein [KO:K15918] [EC:2.7.1.31]
NCS57_01215200  SRP54 domain-containing protein [KO:K15918] [EC:2.7.1.31]
NCS57_00276400  hypothetical protein [KO:K15918] [EC:2.7.1.31]
NCS57_01111500  Phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NCS57_00288500  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
NCS57_01161300  Phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
NCS57_00420100  Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
NCS57_01385700  hypothetical protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
NCS57_00838900  hypothetical protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
NCS57_00624200  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
NCS57_01086300  Amine oxidase [KO:K00274] [EC:1.4.3.4]
NCS57_01319200  Amine oxidase [KO:K00274] [EC:1.4.3.4]
NCS57_01459100  Amine oxidase [KO:K00274] [EC:1.4.3.4]
NCS57_00532700  Amine oxidase [KO:K00274] [EC:1.4.3.4]
NCS57_00796600  Amine oxidase [KO:K00274] [EC:1.4.3.4]
NCS57_00904000  Amine oxidase [KO:K00276] [EC:1.4.3.21]
NCS57_00932000  Amine oxidase [KO:K00276] [EC:1.4.3.21]
NCS57_01067800  Amine oxidase [KO:K00276] [EC:1.4.3.21]
NCS57_01075000  Amine oxidase [KO:K00276] [EC:1.4.3.21]
NCS57_00198600  Amine oxidase [KO:K00276] [EC:1.4.3.21]
NCS57_01285900  Amine oxidase [KO:K00276] [EC:1.4.3.21]
NCS57_01412200  Amine oxidase [KO:K00276] [EC:1.4.3.21]
NCS57_00326700  Amine oxidase [KO:K00276] [EC:1.4.3.21]
NCS57_01491800  Amine oxidase [KO:K00276] [EC:1.4.3.21]
NCS57_00471300  Amine oxidase [KO:K00276] [EC:1.4.3.21]
NCS57_00521700  Amine oxidase [KO:K00276] [EC:1.4.3.21]
NCS57_00378600  Glycine cleavage system P protein [KO:K00281] [EC:1.4.4.2]
NCS57_00068800  Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
NCS57_00549800  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
NCS57_00994600  Glycine cleavage system H protein [KO:K02437]
NCS57_00378700  Glycine cleavage system H protein [KO:K02437]
NCS57_00004400  DAO domain-containing protein [KO:K00273] [EC:1.4.3.3]
NCS57_01162900  DAO domain-containing protein [KO:K00273] [EC:1.4.3.3]
NCS57_00226900  hypothetical protein [KO:K00273] [EC:1.4.3.3]
NCS57_01468000  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
NCS57_00343100  DAO domain-containing protein [KO:K00273] [EC:1.4.3.3]
NCS57_00352000  DAO domain-containing protein [KO:K00273] [EC:1.4.3.3]
NCS57_00461200  DAO domain-containing protein [KO:K00273] [EC:1.4.3.3]
NCS57_00505900  DAO domain-containing protein [KO:K00273] [EC:1.4.3.3]
NCS57_00506000  DAO domain-containing protein [KO:K00273] [EC:1.4.3.3]
NCS57_00517400  hypothetical protein [KO:K00273] [EC:1.4.3.3]
NCS57_00536800  DAO domain-containing protein [KO:K00273] [EC:1.4.3.3]
NCS57_00553000  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
NCS57_00306400  hypothetical protein [KO:K00130] [EC:1.2.1.8]
NCS57_01312700  hypothetical protein [KO:K00309] [EC:1.5.3.10]
NCS57_00958600  DAO domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_00993500  DAO domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_01014600  DAO domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_01254100  DAO domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_01301600  DAO domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_01320000  DAO domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_01330100  DAO domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_01456200  DAO domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_01461600  DAO domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_00332200  DAO domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_00343200  FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_00391000  DAO domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_00477800  DAO domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_00653300  DAO domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_00676000  DAO domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
NCS57_01394000  PALP domain-containing protein [KO:K01697] [EC:4.2.1.22]
NCS57_00066000  Cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
NCS57_00159200  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
NCS57_01314400  PALP domain-containing protein [KO:K01754] [EC:4.3.1.19]
NCS57_00748500  PALP domain-containing protein [KO:K01754] [EC:4.3.1.19]
NCS57_01126500  PALP domain-containing protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
NCS57_00378500  PALP domain-containing protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
NCS57_00855800  D-ser-dehydrat domain-containing protein [KO:K20498] [EC:4.3.1.18]
NCS57_00709600  Tryptophan synthase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
fkr00010  Glycolysis / Gluconeogenesis
fkr00020  Citrate cycle (TCA cycle)
fkr00230  Purine metabolism
fkr00250  Alanine, aspartate and glutamate metabolism
fkr00270  Cysteine and methionine metabolism
fkr00290  Valine, leucine and isoleucine biosynthesis
fkr00300  Lysine biosynthesis
fkr00330  Arginine and proline metabolism
fkr00460  Cyanoamino acid metabolism
fkr00470  D-Amino acid metabolism
fkr00564  Glycerophospholipid metabolism
fkr00600  Sphingolipid metabolism
fkr00620  Pyruvate metabolism
fkr00630  Glyoxylate and dicarboxylate metabolism
fkr00640  Propanoate metabolism
fkr00680  Methane metabolism
fkr00860  Porphyrin metabolism
fkr00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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