KEGG   PATHWAY: gcl03013
Entry
gcl03013                    Pathway                                
Name
Nucleocytoplasmic transport - Gymnogyps californianus (California condor)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
gcl03013  Nucleocytoplasmic transport
gcl03013

Other DBs
GO: 0050658
Organism
Gymnogyps californianus (California condor) [GN:gcl]
Gene
127012953  nucleoporin NUP42 isoform X1 [KO:K14321]
127023780  mRNA export factor GLE1 [KO:K18723]
127024718  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX19B-like [KO:K18655] [EC:5.6.2.7]
127023393  mRNA export factor RAE1 isoform X1 [KO:K14298]
127029699  nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
127023612  nuclear pore complex protein Nup214 [KO:K14317]
127024433  nuclear pore complex protein Nup88 [KO:K14318]
127029393  ranBP2-like and GRIP domain-containing protein 4 isoform X1 [KO:K12172] [EC:2.3.2.-]
127025275  ran GTPase-activating protein 1 [KO:K14319]
127022289  SUMO-conjugating enzyme UBC9 isoform X1 [KO:K10577]
127018278  small ubiquitin-related modifier 1 isoform X1 [KO:K12160]
127019973  small ubiquitin-related modifier 3 isoform X1 [KO:K12160]
127023919  small ubiquitin-related modifier 2 isoform X1 [KO:K12160]
127016455  nuclear pore complex protein Nup160 [KO:K14303]
127024105  nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
127021626  protein SEC13 homolog [KO:K14004]
127024440  nuclear pore complex protein Nup107 [KO:K14301]
127014312  nuclear pore complex protein Nup133 isoform X1 [KO:K14300]
127013120  nucleoporin SEH1 isoform X1 [KO:K14299]
127014563  nucleoporin Nup43 isoform X1 [KO:K14305]
127020800  nucleoporin Nup37 [KO:K14302]
127015208  protein ELYS-like isoform X1 [KO:K25129]
127019481  nuclear pore glycoprotein p62-like isoform X1 [KO:K14306]
127019482  nuclear pore glycoprotein p62-like [KO:K14306]
127020039  nucleoporin p58/p45 isoform X1 [KO:K14307]
127016131  nucleoporin p54 isoform X1 [KO:K14308]
127018688  nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
127023615  nucleoporin NUP188 [KO:K14311]
127027083  nuclear pore complex protein Nup155 [KO:K14312]
127028948  LOW QUALITY PROTEIN: nuclear pore complex protein Nup155-like [KO:K14312]
127021221  nuclear pore complex protein Nup93 [KO:K14309]
127018267  nucleoporin NUP35 isoform X1 [KO:K14313]
127019376  nucleoporin NDC1 [KO:K14315]
127021448  nuclear pore membrane glycoprotein 210 [KO:K14314]
127024571  nuclear envelope pore membrane protein POM 121 [KO:K14316]
127015815  transmembrane protein 33 [KO:K20724]
127018993  nucleoprotein TPR [KO:K09291]
127029354  nuclear pore complex protein Nup50 [KO:K14295]
127013740  nuclear pore complex protein Nup153 [KO:K14296]
127020087  sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
127014619  importin subunit alpha-5 [KO:K23940]
127022276  importin subunit alpha-8 [KO:K15043]
127024140  importin subunit alpha-1 [KO:K15043]
127019882  importin subunit alpha-3 [KO:K23583]
127029478  importin subunit alpha-4 [KO:K23583]
127025011  importin subunit alpha-7 isoform X1 [KO:K15042]
127013982  importin subunit alpha-6 isoform X1 [KO:K15042]
127026433  importin subunit beta-1 isoform X1 [KO:K14293]
127027082  transportin-1 [KO:K18752]
127029094  LOW QUALITY PROTEIN: transportin-1-like [KO:K18752]
127019334  transportin-3 [KO:K15436]
127015844  importin-5 [KO:K20222]
127016375  importin-7 [KO:K20223]
127014775  importin-8 [KO:K18755]
127026185  importin-9 isoform X1 [KO:K20224]
127027672  importin-11 isoform X1 [KO:K25201]
127029104  importin-11-like [KO:K25201]
127019292  importin-13 isoform X1 [KO:K25202]
127020612  LOW QUALITY PROTEIN: snurportin-1 [KO:K13151]
127014102  exportin-1 [KO:K14290]
127023265  exportin-2 [KO:K18423]
127019039  exportin-T isoform X1 [KO:K14288]
127016730  exportin-4 [KO:K25203]
127014243  exportin-5 isoform X1 [KO:K14289]
127022460  exportin-6 isoform X1 [KO:K25204]
127025217  exportin-7 isoform X1 [KO:K18460]
127022017  ran-binding protein 17 [KO:K24115]
127022911  GTP-binding nuclear protein Ran [KO:K07936]
127023179  elongation factor 1-alpha 2 [KO:K03231]
127015324  elongation factor 1-alpha 1 [KO:K03231]
127027241  phosphorylated adapter RNA export protein [KO:K14291]
127028085  LOW QUALITY PROTEIN: phosphorylated adapter RNA export protein-like [KO:K14291]
127027818  nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
127029009  nuclear cap-binding protein subunit 1-like [KO:K12882]
127019610  nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
127020208  nuclear cap-binding protein subunit 2 [KO:K12883]
127020008  60S ribosomal export protein NMD3 [KO:K07562]
127019171  protein mago nashi homolog [KO:K12877]
127026406  protein CASC3 isoform X1 [KO:K14323]
127014657  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
127028365  histone deacetylase complex subunit SAP18 [KO:K14324]
127022317  RNA-binding protein with serine-rich domain 1 [KO:K14325]
127016784  pinin [KO:K13114]
127024023  THO complex subunit 4 [KO:K12881]
127025416  regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
127029353  regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
127019670  regulator of nonsense transcripts 3B [KO:K14328]
127020311  regulator of nonsense transcripts 3A [KO:K14328]
127019667  NTF2-related export protein 2 isoform X1 [KO:K14285]
127024944  serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
127013085  THO complex subunit 1 isoform X1 [KO:K12878]
127019486  THO complex subunit 2 [KO:K12879]
127022779  THO complex subunit 5 homolog isoform X1 [KO:K13174]
127021507  THO complex subunit 7 homolog isoform X1 [KO:K13176]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
gcl03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

DBGET integrated database retrieval system