KEGG   PATHWAY: his00983
Entry
his00983                    Pathway                                
Name
Drug metabolism - other enzymes - Hermetia illucens (black soldier fly)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
his00983  Drug metabolism - other enzymes
his00983

Organism
Hermetia illucens (black soldier fly) [GN:his]
Gene
119658900  inosine-5'-monophosphate dehydrogenase-like [KO:K00088] [EC:1.1.1.205]
119660834  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
119649421  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
119647022  indole-3-acetaldehyde oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
119647097  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
119657859  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
119647240  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
119651539  LOW QUALITY PROTEIN: indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
119656328  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
119646436  indole-3-acetaldehyde oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
119651599  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
119660213  neuroligin-4, Y-linked isoform X1 [KO:K01044] [EC:3.1.1.1]
119648758  UDP-glycosyltransferase UGT5 [KO:K00699] [EC:2.4.1.17]
119660056  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
119660067  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
119650123  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119650142  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
119650150  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
119650155  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
119661097  UDP-glycosyltransferase UGT4-like [KO:K00699] [EC:2.4.1.17]
119661099  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119661157  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119661231  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119661741  UDP-glycosyltransferase UGT4-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119653869  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119653928  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
119654243  UDP-glycosyltransferase UGT5 [KO:K00699] [EC:2.4.1.17]
119654563  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
119655088  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
119655089  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
119655065  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
119655873  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
119646378  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
119654257  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
119654258  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
119660976  cytidine deaminase-like isoform X1 [KO:K01489] [EC:3.5.4.5]
119657313  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
119658890  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
119646482  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
119650688  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
119652689  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
119658709  uridine-cytidine kinase isoform X1 [KO:K00876] [EC:2.7.1.48]
119648767  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
119659530  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
119659831  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
119646829  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
119661431  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
119659672  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
119646911  LOW QUALITY PROTEIN: nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
119659228  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
119649317  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
119646240  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
119651316  probable deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
119646741  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119657417  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
119657634  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
119657738  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
119657985  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
119658236  prostaglandin E synthase-like [KO:K00799] [EC:2.5.1.18]
119658347  glutathione S-transferase E14 [KO:K00799] [EC:2.5.1.18]
119648229  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119648744  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119648745  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
119648746  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119648747  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119648748  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119648749  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119649263  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119659919  glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
119659930  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119659938  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119649467  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119649468  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119649709  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119649710  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119650050  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119650240  inactive glutathione S-transferase D3-like [KO:K00799] [EC:2.5.1.18]
119650963  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119651265  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119651266  glutathione S-transferase D1-like [KO:K00799] [EC:2.5.1.18]
119652625  glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]
119652651  glutathione S-transferase D7 isoform X1 [KO:K00799] [EC:2.5.1.18]
119654705  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119654706  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119654707  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119654836  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119655113  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119655766  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
119657205  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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