KEGG   PATHWAY: hmd00260
Entry
hmd00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Halomonas meridiana
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
hmd00260  Glycine, serine and threonine metabolism
hmd00260

Module
hmd_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:hmd00260]
hmd_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:hmd00260]
hmd_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:hmd00260]
hmd_M00555  Betaine biosynthesis, choline => betaine [PATH:hmd00260]
hmd_M00621  Glycine cleavage system [PATH:hmd00260]
hmd_M00919  Ectoine degradation, ectoine => aspartate [PATH:hmd00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Halomonas meridiana [GN:hmd]
Gene
CTT34_03795  aspartate kinase [KO:K00928] [EC:2.7.2.4]
CTT34_07930  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CTT34_02590  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CTT34_15375  homoserine kinase [KO:K02204] [EC:2.7.1.39]
CTT34_02595  threonine synthase [KO:K01733] [EC:4.2.3.1]
CTT34_12815  threonine aldolase [KO:K01620] [EC:4.1.2.48]
CTT34_04275  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
CTT34_12515  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CTT34_14390  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CTT34_15320  glycerate kinase [KO:K00865] [EC:2.7.1.165]
CTT34_00145  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
CTT34_16890  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CTT34_17110  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CTT34_09820  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
CTT34_11860  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
CTT34_09710  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
CTT34_09690  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
CTT34_05470  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CTT34_09705  gcvH; glycine cleavage system protein H [KO:K02437]
CTT34_15550  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
CTT34_10540  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
CTT34_10535  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
CTT34_15820  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
CTT34_14060  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
CTT34_00095  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
CTT34_03565  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
CTT34_07955  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
CTT34_13125  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
CTT34_07950  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
CTT34_13130  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
CTT34_09375  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
CTT34_09380  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
CTT34_09370  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
CTT34_15390  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
CTT34_14385  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
CTT34_14380  doeB; N-alpha-acetyl diaminobutyric acid deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
CTT34_14365  hypothetical protein [KO:K15785] [EC:2.6.1.76]
CTT34_14370  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
hmd00010  Glycolysis / Gluconeogenesis
hmd00020  Citrate cycle (TCA cycle)
hmd00230  Purine metabolism
hmd00250  Alanine, aspartate and glutamate metabolism
hmd00270  Cysteine and methionine metabolism
hmd00290  Valine, leucine and isoleucine biosynthesis
hmd00300  Lysine biosynthesis
hmd00330  Arginine and proline metabolism
hmd00460  Cyanoamino acid metabolism
hmd00470  D-Amino acid metabolism
hmd00564  Glycerophospholipid metabolism
hmd00620  Pyruvate metabolism
hmd00630  Glyoxylate and dicarboxylate metabolism
hmd00640  Propanoate metabolism
hmd00680  Methane metabolism
hmd00860  Porphyrin metabolism
hmd00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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