KEGG   PATHWAY: hsy04146
Entry
hsy04146                    Pathway                                
Name
Peroxisome - Hydractinia symbiolongicarpus
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
hsy04146  Peroxisome
hsy04146

Other DBs
GO: 0005777
Organism
Hydractinia symbiolongicarpus [GN:hsy]
Gene
130662354  peroxisomal biogenesis factor 3-like [KO:K13336]
130636455  peroxisomal biogenesis factor 19-like [KO:K13337]
130630225  ATP-binding cassette sub-family D member 3-like [KO:K05677] [EC:7.6.2.4]
130645390  peroxisomal ATPase PEX1-like isoform X1 [KO:K13338]
130636407  peroxisomal ATPase PEX6-like [KO:K13339]
130641586  peroxisomal targeting signal 1 receptor-like isoform X1 [KO:K13342]
130613900  peroxisomal membrane protein PEX14-like [KO:K13343]
130655112  peroxisomal membrane protein PEX13-like [KO:K13344]
130649929  putative peroxisome assembly protein 12 [KO:K13345]
130648082  putative peroxisome assembly protein 12 [KO:K13345]
130642090  peroxisome assembly protein 10-A-like [KO:K13346]
130636298  peroxisome biogenesis factor 2-like [KO:K06664]
130612074  peroxisomal membrane protein 2-like [KO:K13348]
130644978  PXMP2/4 family protein 3-like [KO:K13348]
130646908  protein Mpv17-like [KO:K13348]
130647230  protein Mpv17-like [KO:K13348]
130648670  uncharacterized protein LOC130648670 [KO:K13348]
130647147  PXMP2/4 family protein 4-like [KO:K13349]
130647148  PXMP2/4 family protein 4-like [KO:K13349]
130645404  peroxisomal membrane protein 11A-like [KO:K13352]
130649636  peroxisomal membrane protein PMP34-like [KO:K13354]
130621646  2-hydroxyacyl-CoA lyase 1-like [KO:K12261] [EC:4.1.2.63]
130640851  alpha-methylacyl-CoA racemase-like [KO:K01796] [EC:5.1.99.4]
130643822  alpha-methylacyl-CoA racemase-like [KO:K01796] [EC:5.1.99.4]
130654028  phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
130640800  uncharacterized protein LOC130640800 [KO:K00232] [EC:1.3.3.6]
130641180  uncharacterized protein LOC130641180 [KO:K00232] [EC:1.3.3.6]
130645035  uncharacterized protein LOC130645035 [KO:K00232] [EC:1.3.3.6]
130624168  peroxisomal acyl-coenzyme A oxidase 3-like [KO:K00232] [EC:1.3.3.6]
130624169  peroxisomal acyl-coenzyme A oxidase 3-like [KO:K00232] [EC:1.3.3.6]
130623533  peroxisomal multifunctional enzyme type 2-like [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
130630623  sterol carrier protein 2-like isoform X1 [KO:K08764] [EC:2.3.1.176]
130657189  sterol carrier protein 2-like isoform X1 [KO:K08764] [EC:2.3.1.176]
130662424  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
130624222  acyl-coenzyme A amino acid N-acyltransferase 2-like isoform X1 [KO:K00659] [EC:2.3.1.65 3.1.2.2]
130648508  acyl-coenzyme A amino acid N-acyltransferase 1-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
130630181  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like isoform X1 [KO:K12663] [EC:5.3.3.21]
130626150  ATP-binding cassette sub-family D member 1-like [KO:K05675] [EC:7.6.2.4]
130655242  lysosomal cobalamin transporter ABCD4-like [KO:K05678] [EC:7.6.2.8]
130636352  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
130621801  peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
130614340  enoyl-CoA delta isomerase 2-like [KO:K13239] [EC:5.3.3.8]
130614149  peroxisomal coenzyme A diphosphatase NUDT7-like [KO:K17879] [EC:3.6.1.77]
130654235  NAD-capped RNA hydrolase NUDT12-like isoform X1 [KO:K03426] [EC:3.6.1.22]
130613139  acyl-coenzyme A diphosphatase NUDT19-like isoform X1 [KO:K13355] [EC:3.6.1.77]
130612340  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
130612499  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
130622038  peroxisomal carnitine O-octanoyltransferase-like isoform X1 [KO:K05940] [EC:2.3.1.137]
130656622  dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
130636569  alkyldihydroxyacetonephosphate synthase, peroxisomal-like [KO:K00803] [EC:2.5.1.26]
130613075  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
130642123  mevalonate kinase-like isoform X1 [KO:K00869] [EC:2.7.1.36]
130655013  phosphomevalonate kinase-like [KO:K13273] [EC:2.7.4.2]
130655014  phosphomevalonate kinase-like [KO:K13273] [EC:2.7.4.2]
130656998  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
130621230  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
130621820  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
130624170  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
130629276  isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
130646929  isocitrate dehydrogenase [NADP], mitochondrial-like isoform X1 [KO:K00031] [EC:1.1.1.42]
130624033  peroxisomal sarcosine oxidase-like isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
130647272  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
130648315  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
130656623  2-Hydroxyacid oxidase 1-like isoform X1 [KO:K11517] [EC:1.1.3.15]
130656629  uncharacterized protein LOC130656629 isoform X1 [KO:K11517] [EC:1.1.3.15]
130656630  uncharacterized protein LOC130656630 [KO:K11517] [EC:1.1.3.15]
130657737  2-Hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
130645595  catalase-like [KO:K03781] [EC:1.11.1.6]
130644343  uncharacterized protein LOC130644343 [KO:K04565] [EC:1.15.1.1]
130646280  superoxide dismutase [Cu-Zn] 5-like [KO:K04565] [EC:1.15.1.1]
130641534  superoxide dismutase [Mn/Fe]-like [KO:K04564] [EC:1.15.1.1]
130622627  superoxide dismutase [Mn], mitochondrial-like [KO:K04564] [EC:1.15.1.1]
130647548  superoxide dismutase [Mn] 2-like [KO:K04564] [EC:1.15.1.1]
130628992  nitric oxide synthase, inducible-like isoform X1 [KO:K13241] [EC:1.14.13.39]
130613701  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
hsy00071  Fatty acid degradation
hsy00230  Purine metabolism
hsy00564  Glycerophospholipid metabolism
hsy00565  Ether lipid metabolism
hsy00830  Retinol metabolism
hsy00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   
LinkDB

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