KEGG   PATHWAY: hvi00983
Entry
hvi00983                    Pathway                                
Name
Drug metabolism - other enzymes - Homalodisca vitripennis (glassy-winged sharpshooter)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
hvi00983  Drug metabolism - other enzymes
hvi00983

Organism
Homalodisca vitripennis (glassy-winged sharpshooter) [GN:hvi]
Gene
124369001  inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
124362093  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
124368019  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124368021  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124369924  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124361276  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124373373  indole-3-acetaldehyde oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124373399  indole-3-acetaldehyde oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124353553  xanthine dehydrogenase 1-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124353562  LOW QUALITY PROTEIN: indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124353847  LOW QUALITY PROTEIN: indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124364531  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124365030  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124365448  xanthine dehydrogenase 1-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124356567  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124364959  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
124365276  inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.66]
124354619  neuroligin-4, Y-linked-like [KO:K01044] [EC:3.1.1.1]
124369783  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124369824  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124359966  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124370565  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124372159  LOW QUALITY PROTEIN: UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124372952  LOW QUALITY PROTEIN: UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124373602  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124362431  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124374548  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124352719  LOW QUALITY PROTEIN: UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124352720  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124352721  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124353662  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124353979  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354323  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354733  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354735  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354736  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124354942  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124354943  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124354945  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124354947  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124354948  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124354958  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354959  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124354963  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124365848  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124365857  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124365858  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124355454  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124355520  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124355521  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124365982  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124366202  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124355879  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124355885  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124356360  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124356361  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124356362  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124368034  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
124364129  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
124362794  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
124357981  thymidine phosphorylase-like isoform X1 [KO:K00758] [EC:2.4.2.4]
124368671  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
124369118  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
124359037  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
124369763  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
124360141  uridine-cytidine kinase isoform X1 [KO:K00876] [EC:2.7.1.48]
124353867  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
124368243  deoxycytidine kinase 2-like [KO:K00857] [EC:2.7.1.21]
124358938  thymidine kinase 2, mitochondrial-like [KO:K00857] [EC:2.7.1.21]
124370667  deoxynucleoside kinase-like [KO:K00857] [EC:2.7.1.21]
124372856  deoxynucleoside kinase-like [KO:K00857] [EC:2.7.1.21]
124354408  thymidine kinase, cytosolic-like [KO:K00857] [EC:2.7.1.21]
124354396  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
124362590  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
124362592  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
124356673  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
124353678  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
124373441  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
124362669  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
124362945  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
124365068  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
124370431  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
124371390  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
124372440  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
124372690  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
124375177  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
124355149  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
124367424  deoxyuridine 5'-triphosphate nucleotidohydrolase-like isoform X1 [KO:K01520] [EC:3.6.1.23]
124367438  deoxyuridine 5'-triphosphate nucleotidohydrolase-like isoform X1 [KO:K01520] [EC:3.6.1.23]
124357962  glutathione S-transferase D5-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124368352  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124358654  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124369242  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124371224  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361800  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361941  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124361943  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361944  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361945  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124373887  LOW QUALITY PROTEIN: glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124363353  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124353840  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
124366181  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124355869  glutathione S-transferase theta-2-like [KO:K00799] [EC:2.5.1.18]
124356706  microsomal glutathione S-transferase 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124367172  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124367503  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
124367723  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367830  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367831  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124367832  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367833  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367834  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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