KEGG   PATHWAY: itr04148
Entry
itr04148                    Pathway                                
Name
Efferocytosis - Ipomoea triloba (trilobed morning glory)
Class
Cellular Processes; Transport and catabolism
Pathway map
itr04148  Efferocytosis
itr04148

Organism
Ipomoea triloba (trilobed morning glory) [GN:itr]
Gene
116028362  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
116005302  mitogen-activated protein kinase homolog NTF6 [KO:K04371] [EC:2.7.11.24]
115999747  mitogen-activated protein kinase kinase 6 [KO:K04368] [EC:2.7.12.2]
116006465  uncharacterized protein LOC116006465 [KO:K17398] [EC:2.1.1.37]
116027431  calcium-transporting ATPase 3, endoplasmic reticulum-type [KO:K05853] [EC:7.2.2.10]
115997478  protein-tyrosine-phosphatase IBR5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116004308  phospholipid-transporting ATPase 3-like [KO:K14802] [EC:7.6.2.1]
116006100  phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
116006507  phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
116025351  phospholipid-transporting ATPase 3-like isoform X1 [KO:K14802] [EC:7.6.2.1]
115997974  phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
116029215  phospholipid-transporting ATPase 1-like isoform X1 [KO:K14802] [EC:7.6.2.1]
116030010  phospholipid-transporting ATPase 1 [KO:K14802] [EC:7.6.2.1]
115999841  ALA-interacting subunit 5-like [KO:K26935]
116013546  putative ALA-interacting subunit 2 [KO:K26935]
116019132  ALA-interacting subunit 3 [KO:K26935]
116017391  putative ALA-interacting subunit 2 [KO:K26935]
116030561  rac-like GTP-binding protein 5 [KO:K04392]
116031241  rac-like GTP-binding protein RAC2 [KO:K04392]
116021262  rac-like GTP-binding protein RHO1 [KO:K04392]
116009816  rac-like GTP-binding protein ARAC8 [KO:K04392]
116013529  rac-like GTP-binding protein ARAC1 [KO:K04392]
116013676  rac-like GTP-binding protein ARAC7 [KO:K04392]
115999246  rac-like GTP-binding protein ARAC1 [KO:K04392]
116015210  rac-like GTP-binding protein RAC13 [KO:K04392]
116029971  rac-like GTP-binding protein ARAC3 [KO:K04392]
116032317  calreticulin-3-like [KO:K08057]
116032525  calreticulin [KO:K08057]
116007664  calreticulin-like [KO:K08057]
116014761  calreticulin-3-like [KO:K08057]
116020038  ras-related protein RHN1-like [KO:K07889]
115997464  ras-related protein RABF1 [KO:K07889]
116013798  LOW QUALITY PROTEIN: ras-related protein RHN1-like [KO:K07889]
116032232  vacuolar sorting protein 3 [KO:K20177]
115997564  vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
115996415  vacuolar protein-sorting-associated protein 11 homolog [KO:K20179]
116011739  vacuolar protein-sorting-associated protein 11 homolog [KO:K20179]
116011466  protein VACUOLELESS1 [KO:K20180]
116009891  vacuolar sorting protein 18 [KO:K20181]
115997124  vacuolar protein-sorting-associated protein 33 homolog [KO:K20182]
116012808  vacuolar sorting protein 39 isoform X1 [KO:K20183]
116016306  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
116030226  ras-related protein Rab7 [KO:K07897]
116003917  ras-related protein Rab7-like [KO:K07897]
116019928  ras-related protein Rab7 [KO:K07897]
116020626  ras-related protein Rab7 [KO:K07897]
116022865  ras-related protein Rab7-like [KO:K07897]
116023255  ras-related protein Rab7 [KO:K07897]
115997323  ras-related protein Rab7-like [KO:K07897]
115999761  ras-related protein Rab7-like isoform X1 [KO:K07897]
116019096  probable vacuolar amino acid transporter YPQ1 isoform X1 [KO:K23678]
116006103  lysosomal amino acid transporter 1 homolog [KO:K23678]
116033475  probable vacuolar amino acid transporter YPQ1 isoform X1 [KO:K23678]
115999895  lysosomal amino acid transporter 1 homolog isoform X1 [KO:K23678]
116017479  arginase 1, mitochondrial-like [KO:K01476] [EC:3.5.3.1]
116017480  arginase 1, mitochondrial [KO:K01476] [EC:3.5.3.1]
116005614  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
116009929  ornithine decarboxylase-like isoform X1 [KO:K01581] [EC:4.1.1.17]
116002826  cytochrome b-c1 complex subunit Rieske-4, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
116027734  cytochrome b-c1 complex subunit Rieske-4, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
116012659  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
116012682  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
116012761  triacylglycerol lipase 1 [KO:K01052] [EC:3.1.1.13]
115999849  triacylglycerol lipase 2 [KO:K01052] [EC:3.1.1.13]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
itr00010  Glycolysis / Gluconeogenesis
itr04145  Phagosome
KO pathway
ko04148   
LinkDB

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