KEGG   PATHWAY: kpne00260
Entry
kpne00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Klebsiella pneumoniae 32192
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kpne00260  Glycine, serine and threonine metabolism
kpne00260

Module
kpne_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:kpne00260]
kpne_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kpne00260]
kpne_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kpne00260]
kpne_M00555  Betaine biosynthesis, choline => betaine [PATH:kpne00260]
kpne_M00621  Glycine cleavage system [PATH:kpne00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Klebsiella pneumoniae 32192 [GN:kpne]
Gene
KU54_025355  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KU54_022925  thrA; aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
KU54_026340  metL; aspartate kinase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
KU54_012655  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KU54_001625  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KU54_022920  serine kinase [KO:K00872] [EC:2.7.1.39]
KU54_022915  threonine synthase [KO:K01733] [EC:4.2.3.1]
KU54_017480  threonine aldolase [KO:K01620] [EC:4.1.2.48]
KU54_006660  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KU54_006230  2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
KU54_016485  ghrA; bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
KU54_001005  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
KU54_005430  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KU54_003055  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KU54_013100  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KU54_015405  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
KU54_018440  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
KU54_022970  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
KU54_000790  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
KU54_021525  oxidoreductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KU54_004360  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KU54_019095  dihydrofolate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KU54_017310  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
KU54_023005  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
KU54_013705  malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
KU54_000765  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
KU54_000770  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
KU54_014355  tynA; tyramine oxidase [KO:K00276] [EC:1.4.3.21]
KU54_004405  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
KU54_004395  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
KU54_022290  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
KU54_021495  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
KU54_004400  glycine cleavage system protein H [KO:K02437]
KU54_019370  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
KU54_019365  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
KU54_003735  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
KU54_003730  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
KU54_005375  serine dehydratase [KO:K01752] [EC:4.3.1.17]
KU54_009675  serine dehydratase [KO:K01752] [EC:4.3.1.17]
KU54_009870  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KU54_025805  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KU54_000125  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
KU54_023295  aldolase [KO:K01753] [EC:4.3.1.18]
KU54_004845  racemase [KO:K25316] [EC:5.1.1.10]
KU54_015400  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
KU54_015395  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
KU54_012465  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
KU54_012460  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kpne00010  Glycolysis / Gluconeogenesis
kpne00020  Citrate cycle (TCA cycle)
kpne00230  Purine metabolism
kpne00250  Alanine, aspartate and glutamate metabolism
kpne00270  Cysteine and methionine metabolism
kpne00290  Valine, leucine and isoleucine biosynthesis
kpne00300  Lysine biosynthesis
kpne00330  Arginine and proline metabolism
kpne00460  Cyanoamino acid metabolism
kpne00470  D-Amino acid metabolism
kpne00564  Glycerophospholipid metabolism
kpne00600  Sphingolipid metabolism
kpne00620  Pyruvate metabolism
kpne00630  Glyoxylate and dicarboxylate metabolism
kpne00640  Propanoate metabolism
kpne00680  Methane metabolism
kpne00860  Porphyrin metabolism
kpne00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system