KEGG PATHWAY: kpnk00260

PATHWAY: kpnk00260

Entry

kpnk00260                   Pathway

Name

Glycine, serine and threonine metabolism - Klebsiella pneumoniae Kp52.145

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

kpnk00260

Glycine, serine and threonine metabolism

Module

kpnk_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:kpnk00260]

kpnk_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:kpnk00260]

kpnk_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kpnk00260]

kpnk_M00555

Betaine biosynthesis, choline => betaine [PATH:kpnk00260]

kpnk_M00621

Glycine cleavage system [PATH:kpnk00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Klebsiella pneumoniae Kp52.145 [GN:kpnk]

Gene

BN49_5021

lysC; highly similar to lysine-sensitive aspartokinase 3 from Escherichia coli strain K12 (sp [KO:K00928] [EC:2.7.2.4]

BN49_4338

thrA; highly similar to bifunctional aspartokinase I-homeserine dehydrogenase I from Escherichia coli O1:K1 - APEC (tr [KO:K12524] [EC:2.7.2.4 1.1.1.3]

BN49_4623

metL; highly similar to bifunctional aspartokinase-homoserine dehydrogenase II from Escherichia coli O44:H18 strain 042 - EAEC (tr [KO:K12525] [EC:2.7.2.4 1.1.1.3]

BN49_2862

asd2; similar to aspartate-semialdehyde dehydrogenase from Escherichia coli O44:H18 strain 042 - EAEC (tr [KO:K00133] [EC:1.2.1.11]

BN49_0317

asd; highly similar to aspartate-semialdehyde dehydrogenase from Escherichia coli B354 (tr [KO:K00133] [EC:1.2.1.11]

BN49_4337

thrB; highly similar to homoserine kinase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K00872] [EC:2.7.1.39]

BN49_4336

thrC; highly similar to threonine synthase from Escherichia coli O103:H2 strain 12009 - EHEC (tr [KO:K01733] [EC:4.2.3.1]

BN49_2000

ltaE; highly similar to low specificity L-threonine aldolase from Escherichia coli strain K12 (sp [KO:K01620] [EC:4.1.2.48]

BN49_4085

glyA; highly similar to serine hydroxymethyltransferase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K00600] [EC:2.1.2.1]

BN49_1143

unnamed protein product; weakly similar to D-isomer specific 2-hydroxyacid dehydrogenase from Acinetobacter radioresistens SH164 (tr [KO:K12972] [EC:1.1.1.79 1.1.1.81]

BN49_2143

ghrA; highly similar to glyoxylate-hydroxypyruvate reductase A from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K12972] [EC:1.1.1.79 1.1.1.81]

BN49_0201

ghrB; highly similar to glyoxylate-hydroxypyruvate reductase B from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

BN49_0985

unnamed protein product; highly similar to putative glycerate kinase from Enterobacter cancerogenus (tr [KO:K00865] [EC:2.7.1.165]

BN49_0568

garK; highly similar to glycerate kinase from Escherichia coli strain SMS-3-5 - SECEC (tr [KO:K00865] [EC:2.7.1.165]

BN49_2799

glxK; weakly similar to glycerate kinase from Bacillus halodurans (sp [KO:K00865] [EC:2.7.1.165]

BN49_2393

ttuD; similar to putative hydroxypyruvate reductase from Agrobacterium vitis (sp [KO:K11529] [EC:2.7.1.165]

BN49_1807

gpmA; highly similar to 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K01834] [EC:5.4.2.11]

BN49_4346

gpmB; highly similar to probable phosphoglycerate mutase GpmB from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K15634] [EC:5.4.2.11]

BN49_0155

gpmI; highly similar to 2,3-bisphosphoglycerate-independent phosphoglycerate mutase from Shigella dysenteriae serotype 1 strain Sd197 (sp [KO:K15633] [EC:5.4.2.12]

BN49_2730

unnamed protein product; highly similar to D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding from Pantoea sp. At-9b (tr [KO:K00058] [EC:1.1.1.95 1.1.1.399]

BN49_1694

unnamed protein product; similar to D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding from Pectobacterium carotovorum (tr [KO:K00058] [EC:1.1.1.95 1.1.1.399]

BN49_0743

serA; highly similar to D-3-phosphoglycerate dehydrogenase from Escherichia coli strain UTI89 - UPEC (tr [KO:K00058] [EC:1.1.1.95 1.1.1.399]

BN49_2034

serC; highly similar to phosphoserine aminotransferase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K00831] [EC:2.6.1.52]

BN49_4353

unnamed protein product; highly similar to C-terminal of phosphoserine phosphatase from Escherichia coli O6 (tr [KO:K01079] [EC:3.1.3.3]

BN49_2700

ydfG; highly similar to NADP-dependent L-serine-L-allo-threonine dehydrogenase YdfG from Escherichia coli O6 (sp [KO:K16066] [EC:1.1.1.381 1.1.1.-]

BN49_0150

kbl; highly similar to 2-amino-3-ketobutyrate coenzyme A ligase from Escherichia coli strain K12 (sp [KO:K00639] [EC:2.3.1.29]

BN49_0151

tdh; highly similar to L-threonine 3-dehydrogenase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K00060] [EC:1.1.1.103]

BN49_2528

maoA; highly similar to primary amine oxidase from Klebsiella aerogenes (sp [KO:K00276] [EC:1.4.3.21]

BN49_0752

gcvP; highly similar to glycine dehydrogenase [decarboxylating] from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K00281] [EC:1.4.4.2]

BN49_0750

gcvT; highly similar to aminomethyltransferase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K00605] [EC:2.1.2.10]

BN49_1230

lpd; similar to dihydrolipoyl dehydrogenase from Rhodococcus erythropolis (tr [KO:K00382] [EC:1.8.1.4]

BN49_4220

lpdA; highly similar to dihydrolipoyl dehydrogenase from Escherichia coli strain UTI89 - UPEC (tr [KO:K00382] [EC:1.8.1.4]

BN49_0751

gcvH; highly similar to glycine cleavage system H protein from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K02437]

BN49_4117

pssA; highly similar to phosphatidylserine synthase from Escherichia coli O157:H7 (tr [KO:K00998] [EC:2.7.8.8]

BN49_1638

betA; highly similar to choline dehydrogenase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K00108] [EC:1.1.99.1]

BN49_1639

betB; highly similar to betaine aldehyde dehydrogenase from Klebsiella pneumoniae strain 342 (sp [KO:K00130] [EC:1.2.1.8]

BN49_0695

unnamed protein product; highly similar to cysteine synthase from Enterobacter sp. (tr [KO:K01697] [EC:4.2.1.22]

BN49_0694

unnamed protein product; highly similar to putative cystathionine gamma-lyase from Enterobacter sp (tr [KO:K01758] [EC:4.4.1.1]

BN49_3435

unnamed protein product; highly similar to L-serine ammonia-lyase from Escherichia coli B354 (tr [KO:K01752] [EC:4.3.1.17]

BN49_0974

sdaB; highly similar to L-serine deaminase II from Escherichia coli O111:H-strain 11128 - EHEC (tr [KO:K01752] [EC:4.3.1.17]

BN49_3396

tdcB; highly similar to threonine dehydratase, catabolic from Escherichia coli strain UTI89 - UPEC (tr [KO:K01754] [EC:4.3.1.19]

BN49_4588

ilvA; highly similar to threonine deaminase from Escherichia coli O7:K1 strain IAI39 - ExPEC (tr [KO:K01754] [EC:4.3.1.19]

BN49_0026

dsdA; highly similar to D-serine dehydratase from Escherichia coli O81 strain ED1a (sp [KO:K01753] [EC:4.3.1.18]

BN49_4401

unnamed protein product; highly similar to putative D-serine ammonia-lyase from Escherichia coli strain SMS-3-5 - SECEC (tr [KO:K01753] [EC:4.3.1.18]

BN49_0854

unnamed protein product; highly similar to C-terminal region of putative racemase from Escherichia coli O17:K52:H18 strain UMN026 - ExPEC (tr [KO:K25316] [EC:5.1.1.10]

BN49_2394

trpA; highly similar to tryptophan synthase alpha chain from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K01695] [EC:4.2.1.20]

BN49_2395

trpB; highly similar to tryptophan synthase beta chain from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K01696] [EC:4.2.1.20]

BN49_2899

dat; similar to diaminobutyrate--2-oxoglutarate aminotransferase from Acinetobacter baumannii (sp [KO:K00836] [EC:2.6.1.76]

BN49_2900

ddc; similar to L-2,4-diaminobutyrate decarboxylase from Acinetobacter baumannii (sp [KO:K13745] [EC:4.1.1.86]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721